antipyrine

phenazone

CAS: 60-80-0 C11 H12 N2 O MW: 188.22984000

Identification

Nameantipyrine
IUPAC1,5-dimethyl-2-phenylpyrazol-3-one
CAS Number60-80-0
EINECS200-486-6
FDA UNIIT3CHA1B51H
Molecular FormulaC11 H12 N2 O
Molecular Weight188.22984000
MDL NumberMFCD00003146
Nikkaji NumberJ2.340J
Beilstein157775
XlogP30.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 114.00 °C. @ 760.00 mm Hg
Boiling Point 319.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.000030 mmHg @ 25.00 °C. (est)
Flash Point 239.00 °F. TCC ( 114.80 °C. ) (est)
logP (o/w) 0.380
Soluble in water, 5.19E+04 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintravenous-cat LDLo 525 mg/kg
Dermal Toxicitysubcutaneous-cat LDLo 700 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for antipyrine usage levels up tonot for fragrance use.
Recommendation for antipyrine flavor usage levels up tonot for flavor use.

Beijing Lys Chemicals Co, LTD.

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Penta International Corporation

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At Penta, our products and services help businesses do business better.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

analgesine anodynin 3- antipyrine antipyrinum auralgan azophen 1,2- dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one 2,3- dimethyl-1-phenyl-3-pyrazolin-5-one 2,3- dimethyl-1-phenyl-5-pyrazolone 1,5- dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 1,5- dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one 1,5- dimethyl-2-phenyl-3-pyrazolone 1,5- dimethyl-2-phenylpyrazol-3-one dimethyloxyquinazine fenazona fenazone methozin parodyne phenazon phenazone phenozone 1- phenyl-2,3-dimethyl-5-pyrazolone 1- phenyl-2,3-dimethylpyrazole-5-one phenyldimethylpyrazolone pyramidone 3H- pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl- pyrazophyl sedatin PubMed: A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices. PubMed: Rapid enzymatic method for pectin methyl esters determination. PubMed: Analysis of the monosaccharide composition of water-soluble polysaccharides from Sargassum fusiforme by high performance liquid chromatography/electrospray ionisation mass spectrometry. PubMed: [Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS]. PubMed: The predominance of type I oligosaccharides is a feature specific to human breast milk. PubMed: CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats. PubMed: Transformation of phenazone-type drugs during chlorination. PubMed: Passage of 4-nonylphenol across the human placenta. PubMed: Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion. PubMed: Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism. PubMed: Transplacental transfer of nitrosodimethylamine in perfused human placenta. PubMed: Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta. PubMed: Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. PubMed: Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography. PubMed: Modulation of antipyrine clearance by polysaccharide peptide (PSP) isolated from Coriolus versicolor in the rat. PubMed: Determination of polar drug residues in sewage and surface water applying liquid chromatography-tandem mass spectrometry. PubMed: Detection and identification of phenazone-type drugs and their microbial metabolites in ground and drinking water applying solid-phase extraction and gas chromatography with mass spectrometric detection. PubMed: Determination of 1-phenyl-3-methyl-5-pyrazolone-labeled carbohydrates by liquid chromatography and micellar electrokinetic chromatography. PubMed: [Experience of biologically active supplements to food containing indoles and isothiocyanates in patients with chronic viral hepatitis]. PubMed: Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. PubMed: Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. PubMed: Migraine in older patients: a case report and management strategies. PubMed: Endogenous benzodiazepines. PubMed: The pharmacokinetics of ziprasidone in subjects with normal and impaired hepatic function. PubMed: Influence of diet and nutritional status on drug metabolism. PubMed: Pharmacokinetics of pantoprazole in man. PubMed: Pharmacokinetics of pantoprazole in man. PubMed: Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease. PubMed: Influence of a three-day feed and water deprivation period on gut fill, tissue weights, and tissue composition in mature wethers. PubMed: Clinical pharmacokinetics of lansoprazole. PubMed: Separation and identification of phase I and phase II [14C]antipyrine metabolites in rat and dog urine. PubMed: The effects of Artemisia filifolia and Helenium flexuosum on disposition of antipyrine in rabbits. PubMed: The influence of net water absorption on the permeability of antipyrine and levodopa in the human jejunum. PubMed: Clinical pharmacokinetics of ticlopidine. PubMed: Pharmacokinetics of antipyrine in calves at neonatal period fed with casein supplemented food. PubMed: Clinical pharmacology and pharmacokinetics of oxcarbazepine. PubMed: Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat. PubMed: Chronic physical activity alters hepatobiliary excretory function in rats. PubMed: Pharmacokinetics of dirithromycin. PubMed: Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin. PubMed: Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat. PubMed: Urinary excretion of angiotensin I, II, arginine vasopressin and oxytocin in patients with anaphylactoid reactions. PubMed: Clinical pharmacokinetics in veterinary medicine. PubMed: Species- and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species: cattle, goat, rat and rabbit. PubMed: [Effects of zixoryn on pharmacokinetics of antipyrine in intact and sensitized guinea pigs]. PubMed: Concurrent bromosulphophthalein and antipyrine administration to assess liver blood flow and hepatic enzymes in rats. PubMed: [Evaluation of the inducing action of aroclor 1254 in rats in long-term experiment]. PubMed: Effects of endophyte-infected fescue and cimetidine on respiration rates, rectal temperatures and hepatic mixed function oxidase activity as measured by hepatic antipyrine metabolism in sheep. PubMed: Effect of subacute oral intake of the food antioxidant butylated hydroxyanisole on clinical parameters and phase-I and -II biotransformation capacity in man. PubMed: Pharmacokinetic characteristics of roxatidine. PubMed: Effect of trenbolone and testosterone on the plasma elimination rates of sulfamethazine, trimethoprim, and antipyrine in female dwarf goats. PubMed: Antipyrine absorption and disposition in the elderly. PubMed: Interaction of roxatidine acetate with antacids, food and other drugs. PubMed: Pharmacokinetics of roxatidine in healthy volunteers. PubMed: [The influence of environmental factors, age, sex and menstrual cycle on the metabolism of drugs in the liver]. PubMed: A comparison of the effects of a macrobiotic diet and a Western diet on drug metabolism and plasma lipids in man. PubMed: Starvation induced changes in quantitative measures of liver function in the rat. PubMed: Effect of the immunomodulator tilorone on antipyrine disposition in the rat. PubMed: Antipyrine metabolism in African villagers. PubMed: Effects of parenteral nutritional regimens on oxidative drug metabolism. PubMed: Heterogeneity of hepatic aryl hydrocarbon hydroxylase activity in feral winter flounder: relevance to carcinogenicity testing. PubMed: Clinical pharmacokinetics of labetalol. PubMed: Petrol exposure and hepatic enzyme activity. PubMed: Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man. PubMed: Food interactions affecting the absorption of analgesic and anti-inflammatory agents. PubMed: Food and drug interactions. PubMed: Improved 4-aminoantipyrine colorimetry for detection of residual hydrogen peroxide in noodles, fish paste, dried fish, and herring roe. PubMed: Influence of ascorbic acid and erythorbic acid on drug metabolism in the cynomolgus monkey. PubMed: Research review. Interactions between environmental chemicals and drug biotransformation in man. PubMed: Influence of food on the bioavailability of drugs. PubMed: Bioavailability of D-propoxyphene, acetyl salicylic acid, and phenazone in a combination tablet (Doleron): interindividual variation and influence of food intake. PubMed: The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies. PubMed: Metabolic interactions among environmental chemicals and drugs.