atropine sulfate monohydrate

benzeneacetic acid, a-(hydroxymethyl)-, (6-methyl-6-azabicyclo[3.1.1]hept-3-yl)methyl ester, sulfate (2:1) (salt)

CAS: 5908-99-6 C34 H50 N2 O11 S MW: 694.84270000

Identification

Nameatropine sulfate monohydrate
IUPAC(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate
CAS Number5908-99-6
FDA UNII03J5ZE7KA5
Molecular FormulaC34 H50 N2 O11 S
Molecular Weight694.84270000
MDL NumberMFCD00074815
Beilstein6109275

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 806.70 °C. @ 760.00 mm Hg (est)
Flash Point 827.00 °F. TCC ( 441.70 °C. ) (est)
logP (o/w) 2.137 (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for atropine sulfate monohydrate usage levels up tonot for fragrance use.
Recommendation for atropine sulfate monohydrate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

atropine sulfate benzeneacetic acid, a-(hydroxymethyl)-, (6-methyl-6-azabicyclo[3.1.1]hept-3-yl)methyl ester, sulfate (2:1) (salt) (6- methyl-6-azabicyclo[3.1.1]hept-3-yl)methyl 3-hydroxy-2-phenylpropanoate sulfate (2:1) (8- methyl-8-azabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate PubMed: [Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. PubMed: Quantitative proton nuclear magnetic resonance for the structural and quantitative analysis of atropine sulfate. PubMed: Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior. PubMed: Hyperglycemic and stressogenic effects of monocrotophos in rats: evidence for the involvement of acetylcholinesterase inhibition. PubMed: Effect of atropine sulfate on gastric emptying and gastrocecal transit time evaluated by using the [1-(13)C]acetic acid and lactose-[(13)C]ureide breath test in conscious rats. PubMed: Chinese dumpling scare hits Japan--a case of methamidophos food poisoning. PubMed: Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions. PubMed: Changes in spontaneous contractions of rat ileum by aflatoxin in vitro. PubMed: Impurity profiling of atropine sulfate by microemulsion electrokinetic chromatography. PubMed: Identification and estimation of the levo isomer in raw materials and finished products containing atropine and/or hyoscyamine. PubMed: [Conservative treatment of hypertrophic pyloric stenosis in children]. PubMed: Determination of atropine (hyoscyamine) sulfate in commercial products by liquid chromatography with UV absorbance and fluorescence detection: multilaboratory study. PubMed: Effects of selected anticholinergics on acoustic startle response in rats. PubMed: Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats. PubMed: Central cholinergic regulation of pancreatic polypeptide secretion in conscious dogs. PubMed: The effect of the loss of molar teeth on spatial memory and acetylcholine release from the parietal cortex in aged rats. PubMed: Modulation of pancreatic secretion of individual digestive enzymes in octreotide (SMS 201-995)-infused rats. PubMed: Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival. PubMed: Determination of diphenoxylate hydrochloride and atropine sulfate in combination drug formulations by liquid chromatography. PubMed: A case of swallowing-induced atrioventricular block after myocardial infarction. PubMed: Behavioral and pharmacological assessment of butyrylcholinesterase in rats. PubMed: Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time. PubMed: Effects of atropine on operant test battery performance in rhesus monkeys. PubMed: A subchronic toxicity study of two inhaled aerosolized atropine sulfate formulations in rats and dogs. PubMed: Heart rate spectral analysis of fasting-induced bradycardia of cattle. PubMed: Dissociating performance and learning deficits on spatial navigation tasks in rats subjected to cholinergic muscarinic blockade. PubMed: Physostigmine-insensitive behavioral excitatory effects of atropine in squirrel monkeys. PubMed: Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats. PubMed: Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities. PubMed: Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains. PubMed: Adrenal innervation may be an extrapituitary mechanism able to regulate adrenocortical rhythmicity in rats. PubMed: Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey. PubMed: Changes in schedule-controlled response and schedule-induced drinking after cholinergic blockers in rats. PubMed: The biological properties of aspartame. II. Actions involving the gastrointestinal system. PubMed: Suppression of mouse killing by lateral hypothalamic infusion of atropine sulfate in the rat: a general behavioral suppression. PubMed: Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs. PubMed: Effect of atropine on food-stimulated gastrin release after truncal vagotomy in man. PubMed: After vagotomy atropine suppresses gastrin release by food.