Identification

Nameazelaic acid
IUPACnonanedioic acid
CAS Number123-99-9
EINECS204-669-1
FDA UNIIF2VW3D43YT
Molecular FormulaC9 H16 O4
Molecular Weight188.22332000
MDL NumberMFCD00004432
Nikkaji NumberJ10.058G
Beilstein1101094
CoE Number10079
XlogP31.60 (est)

Regulatory

DG SANTE Food Flavourings08.103 nonanedioic acid
DG SANTE Food Contact Materialsnonanedioic acid
FDA Mainterm (IAUFC)123-99-9 ; AZELAIC ACID
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 106.00 to 107.00 °C. @ 760.00 mm Hg
Boiling Point 356.00 to 357.00 °C. @ 760.00 mm Hg, 228.00 to 229.00 °C. @ 10.00 mm Hg
Vapor Density 6.5 ( Air = 1 )
Flash Point 419.00 °F. TCC ( 215.00 °C. )
logP (o/w) 1.570
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesbuffering agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M,F] > 4000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryindirect food additives: adhesives and components of coatings
Recommendation for azelaic acid usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.0012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)3200 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
Dairy products, excluding products of category 02.0 (01.0)3.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)2.00000
Edible ices, including sherbet and sorbet (03.0)3.00000
Processed fruit (04.1)2.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)10.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)10.00000
Meat and meat products, including poultry and game (08.0)2.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)2.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)5.00000
Foodstuffs intended for particular nutritional uses (13.0)10.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)3.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)10.00000
Ready-to-eat savouries (15.0)15.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)5.00000

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Potential Uses

buffering agents

Natural Occurrence

bean black bean root bean field bean root beer - up to1.5 mg/kg PMC potato leaf

Synonyms

anchoic acid azalaic acid azelaicacid azelainic acid emerox 1110 finacea 1,7- heptane dicarboxylic acid heptanedicarboxylic acid 1,7- heptanedicarboxylic acid lepargylic acid nonane dioic acid 1,9- nonane dioic acid nonanedioic acid 1,9- nonanedioic acid N- nonanedioic acid nonanedioicacid skinorem PubMed: Modification of wheat starch with succinic acid/acetanhydride and azelaic acid/acetanhydride mixtures. II. Chemical and physical properties. J-Stage: Cellulase Applied to the Leaves of Sweet Pepper (Capsicum annuum L. var. grossum) Upregulates the Production of Salicylic and Azelaic Acids PubMed: Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice. PubMed: UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention. PubMed: Effect of ionization and vehicle on skin absorption and penetration of azelaic acid. PubMed: Azelaic acid gel 15% in the management of papulopustular rosacea: a status report on available efficacy data and clinical application. PubMed: Acne vulgaris. PubMed: Alternative therapies for common dermatologic disorders, part 1. PubMed: A review of the diagnosis and treatment of rosacea. PubMed: Phenolic and short-chained aliphatic organic acid constituents of wild oat (Avena fatua L.) seeds. PubMed: Rosacea: a review of current topical, systemic and light-based therapies. PubMed: Acne vulgaris. PubMed: Cumulative irritation potential among metronidazole gel 1%, metronidazole gel 0.75%, and azelaic acid gel 15%. PubMed: The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. PubMed: Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modified protein. PubMed: New treatments and therapeutic strategies for acne. PubMed: Melasma. Etiologic and therapeutic considerations. PubMed: Preliminary studies of a dicarboxylic acid as an energy substrate in man.