benzalphthalide
(E)-3-benzylideneisobenzofuran-1(3H)-one
Identification
| Name | benzalphthalide |
| CAS Number | 575-61-1 |
| EINECS | 209-388-8 |
| FDA UNII | C9E8S3AGYQ |
| Molecular Formula | C15 H10 O2 |
| Molecular Weight | 222.24310000 |
| MDL Number | MFCD00005929 |
| Beilstein | 0083797 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 374.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 314.00 °F. TCC ( 156.90 °C. ) (est) |
| logP (o/w) | 4.270 (est) |
| Soluble in | water, 148.8 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | uv absorbers |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD > 500 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic UV absorber |
| Recommendation for benzalphthalide usage levels up to | not for fragrance use. |
| Recommendation for benzalphthalide flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzal phthalide
1(3H)-I\iso
benzofuranane, 3-(phenylmethylene)-
1(3H)-iso
benzofuranone, 3-(phenylmethylene)-, (3E)-
3-
benzylidene phthalide
(3E)-3-
benzylidene-2-benzofuran-1-one
(3E)-3-
benzylidene-2-benzofuran-1(3H)-one
(E)-3-
benzylideneisobenzofuran-1(3H)-one
3-
benzylidenphthalide
3-[1-
phenyl-meth-(E)-ylidene]-3H-isobenzofuran-1-one
PubMed:
Bacterial degradation of benzalphthalide.
PubMed:
Metabolism of benzalphthalide by Pseudomonas sp.
PubMed:
Identification and quantitation of a 3-benzylidenephthalide contaminant of phenindione tablets and its characterization as a potentially immunogenic substance.
PubMed:
One-step synthesis of isocoumarins and 3-benzylidenephthalides via ligandless Pd-catalyzed oxidative coupling of benzoic acids and vinylarenes.
PubMed:
Synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of RBL-2H3 cells induced by antigen.
PubMed:
Anti-HIV activity of stilbene-related heterocyclic compounds.