benztropine mesylate
8-azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate
Identification
| Name | benztropine mesylate |
| CAS Number | 132-17-2 |
| EINECS | 205-048-8 |
| FDA UNII | WMJ8TL7510 |
| Molecular Formula | C22 H29 N O4 S |
| Molecular Weight | 403.54193000 |
| MDL Number | MFCD00074784 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 143.00 °C. @ 760.00 mm Hg |
| Boiling Point | 409.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000001 mmHg @ 25.00 °C. (est) |
| Flash Point | 248.00 °F. TCC ( 120.10 °C. ) (est) |
| logP (o/w) | 4.962 (est) |
| Soluble in | water, 1.068 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-cat LDLo 33 mg/kg |
| Dermal Toxicity | subcutaneous-guinea pig LD50 80 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for benztropine mesylate usage levels up to | not for fragrance use. |
| Recommendation for benztropine mesylate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether methanesulfonate
(1R,5R)-3-
benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid
benzotropine methanesulfonate
benzotropinemesylate
benztropine mesilate
benztropine methanesulfonate
8-aza
bicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate
8-aza
bicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-, methanesulfonate (9CI)
cobrentin methanesulfonate
cogentin
cogentin methanesulfonate
3-
diphenyl methoxytropane methanesulfonate
endo-3-(
diphenylmethoxy)-8-methyl-8-azoniabicyclo(3.2.1)octane methanesulphonate
3-
diphenylmethoxytropane mesylate
3-
diphenylmethoxytropane methanesulfonate
lopac-B-8262
N-
methylbenztropine
tropine benzohydryl ether methanesulfonate
PubMed:
Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats.
PubMed:
The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.
PubMed:
Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.
PubMed:
Persistence of racial disparities in prescription of first-generation antipsychotics in the USA.
PubMed:
Stimulant actions of histamine H1 antagonists on operant behavior in the squirrel monkey.
PubMed:
Overeating after midbrain 6-hydroxydopamine: prevention by central injection of selective catecholamine reuptake blockers.
PubMed:
Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats.
PubMed:
Delusions of pregnancy associated with increased prolactin concentrations produced by antipsychotic treatment.
PubMed:
The effect of parasympathetic drugs on energy expenditure: relevance to the autonomic hypothesis.
PubMed:
Azacitidine-associated hyperthermia and interstitial pneumonitis in a patient with myelodysplastic syndrome.