benzyl butyl phthalate
phthalic acid, benzyl butyl ester
Identification
| Name | benzyl butyl phthalate |
| CAS Number | 85-68-7 |
| EINECS | 201-622-7 |
| FDA UNII | YPC4PJX59M |
| Molecular Formula | C19 H20 O4 |
| Molecular Weight | 312.36520000 |
| MDL Number | MFCD00009440 |
| Nikkaji Number | J45.539C |
| Beilstein | 2062204 |
| XlogP3 | 4.90 (est) |
Regulatory
| DG SANTE Food Contact Materials | phthalic acid, benzyl butyl ester |
| FDA Mainterm (IAUFC) | 85-68-7 ; BUTYL BENZYL PHTHALATE |
| FDA Regulation | FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.10000 @ 25.00 °C. |
| Melting Point | -35.00 °C. @ 760.00 mm Hg |
| Boiling Point | 370.00 °C. @ 760.00 mm Hg, 250.00 °C. @ 22.50 mm Hg |
| Vapor Density | 10.8 ( Air = 1 ) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | 4.730 |
| Soluble in | water, 2.69 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | not used anymore |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 2330 mg/kg |
| Dermal Toxicity | skin-rat LD50 6700 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | indirect food additives: adhesives and components of coatings |
| Recommendation for benzyl butyl phthalate usage levels up to | not for fragrance use. |
| Recommendation for benzyl butyl phthalate flavor usage levels up to | not for flavor use. |
Penta International Corporation
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Potential Uses
Natural Occurrence
Synonyms
1,2-
benzenedicarboxylic acid benzyl butylester
1,2-
benzenedicarboxylic acid butyl phenylmethyl ester
1,2-
benzenedicarboxylic acid, butyl phenylmethyl ester
2-O-
benzyl 1-O-butyl benzene-1,2-dicarboxylate
benzyl butyl benzene-1,2-dicarboxylate
benzyl N-butyl phthalate
benzylbutylphthalate
butyl benzyl phthalate
N-
butyl benzyl phthalate
butyl phenyl methyl 1,2-benzene dicarboxylate
butyl phenylmethyl 1,2-benzenedicarboxylate
butylbenzyl phthalate
butylbenzylphthalate
palatinol BB
phthalic acid benzyl butyl ester
phthalic acid benzyl N-butyl ester
phthalic acid, benzyl butyl ester
santicizer 160
sicol 160
unimoll BB
PubMed:
The influence of resource strategies on childhood phthalate exposure-The role of REACH in a zero waste society.
PubMed:
Contamination of wines and spirits by phthalates: types of contaminants present, contamination sources and means of prevention.
PubMed:
Benzyl butyl phthalate exposure impairs learning and memory and attenuates neurotransmission and CREB phosphorylation in mice.
PubMed:
Findings of 2731 suspected phthalate-tainted foodstuffs during the 2011 phthalates incident in Taiwan.
PubMed:
Occurrence of Di-(2-ethylhexyl) adipate and phthalate plasticizers in samples of meat, fish, and cheese and their packaging films.
PubMed:
Intake estimates of phthalate esters for South Delhi population based on exposure media assessment.
PubMed:
Childhood exposure to DEHP, DBP and BBP under existing chemical management systems: a comparative study of sources of childhood exposure in Korea and in Denmark.
PubMed:
Determination and pharmacokinetics of di-(2-ethylhexyl) phthalate in rats by ultra performance liquid chromatography with tandem mass spectrometry.
PubMed:
Chronic exposure to benzyl butyl phthalate (BBP) alters social interaction and fear conditioning in male adult rats: alterations in amygdalar MeCP2, ERK1/2 and ERα.
PubMed:
Phthalate metabolites in obese individuals undergoing weight loss: Urinary levels and estimation of the phthalates daily intake.
PubMed:
Determination of phthalate diesters in foods.
PubMed:
Phthalates in indoor dust in Kuwait: implications for non-dietary human exposure.
PubMed:
Detection of migration of phthalates from agglomerated cork stoppers using HPLC-MS/MS.
PubMed:
Occurrence and profiles of phthalates in foodstuffs from China and their implications for human exposure.
PubMed:
Phthalates residues in plastic bottled waters.
PubMed:
Determination of phthalate esters in soil by microemulsion electrokinetic chromatography coupled with accelerated solvent extraction.
PubMed:
Alkylphenols and phthalates in bottled waters.
PubMed:
Reproductive and developmental toxicity of phthalates.
PubMed:
Determination of phthalates in fruit jellies by dispersive SPE coupled with HPLC-MS.
PubMed:
Survey of phthalate levels in Italian oily foods contained in glass jars with PVC gaskets.
PubMed:
Phthalate exposure through food and consumers' risk perception of chemicals in food.
PubMed:
Simultaneous screening and determination eight phthalates in plastic products for food use by sonication-assisted extraction/GC-MS methods.
PubMed:
Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor.
PubMed:
Determination of phthalates and adipate in bottled water by headspace solid-phase microextraction and gas chromatography/mass spectrometry.
PubMed:
Analysis of consumer cosmetic products for phthalate esters.
PubMed:
Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry.
PubMed:
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis.
PubMed:
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate (BBP).
PubMed:
Phthalates inhibit tamoxifen-induced apoptosis in MCF-7 human breast cancer cells.
PubMed:
Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate.
PubMed:
Investigation of the adjuvant and immuno-suppressive effects of benzyl butyl phthalate, phthalic acid and benzyl alcohol in a murine injection model.
PubMed:
Generation of anticalins with specificity for a nonsymmetric phthalic acid ester.
PubMed:
Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy.
PubMed:
Effects of endocrine disrupting chemicals on the microtubule network in Chinese hamster V79 cells in culture and in Sertoli cells in rats.
PubMed:
Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study.
PubMed:
Metabolism of n-butyl benzyl phthalate in the female Wistar rat. Identification of new metabolites.
PubMed:
The plasticizer benzyl butyl phthalate (BBP) inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary DNA adduct formation and tumorigenesis.
PubMed:
Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats.
PubMed:
Evaluation of the OECD 421 reproductive toxicity screening test protocol using butyl benzyl phthalate.
PubMed:
Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats.
PubMed:
Embryolethality and teratogenicity of butyl benzyl phthalate in rats.
PubMed:
Teratogenic evaluation of butyl benzyl phthalate in rats by gastric intubation.
PubMed:
Effect of period of exposure on the developmental toxicity of butyl benzyl phthalate in rats.
PubMed:
Evaluation of the embryolethality of butyl benzyl phthalate by conventional and pair-feeding studies in rats.
PubMed:
Evaluation of the teratogenic potential of the plasticizer butyl benzyl phthalate in rats.
PubMed:
The use of multivariate analysis to compare peroxisome induction data on phthalate esters in rats.