benzyl nicotinate

nicotinic acid, benzyl ester

CAS: 94-44-0 C13 H11 N O2 MW: 213.23607000

Identification

Namebenzyl nicotinate
CAS Number94-44-0
EINECS202-332-3
FDA UNIIS497LCF9C9
Molecular FormulaC13 H11 N O2
Molecular Weight213.23607000
MDL NumberMFCD00023584
Nikkaji NumberJ60.115B
Beilstein0159169
XlogP32.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.16500 @ 25.00 °C.
Boiling Point 334.00 to 335.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000131 mmHg @ 25.00 °C. (est)
Flash Point 313.00 °F. TCC ( 155.80 °C. ) (est)
logP (o/w) 2.400
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantistatic agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 2188 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantistatic and conditioning agents
Recommendation for benzyl nicotinate usage levels up tonot for fragrance use.
Recommendation for benzyl nicotinate flavor usage levels up tonot for flavor use.

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Potential Uses

antistatic agents

Natural Occurrence

not found in nature

Synonyms

benzyl pyridine-3-carboxylate benzylnicotinate nicotinic acid benzyl ester nicotinic acid, benzyl ester phenylmethyl 3-pyridinecarboxylate phenylmethyl pyridine-3-carboxylate pyridine-3-carboxylic acid benzyl ester pyridine-b-carboxylic acid benzyl ester 3- pyridinecarboxylic acid phenylmethyl ester 3- pyridinecarboxylic acid, phenylmethyl ester rubriment Google Patents: Use of Benzyl Nicotinate for Pain Relief PubMed: Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled study. PubMed: Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy. PubMed: Two 1,4-dihydropyridine derivatives with potential calcium-channel antagonist activity. PubMed: Degradation kinetics of benzyl nicotinate in aqueous solution. PubMed: Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry. PubMed: Measurement of drug and macromolecule diffusion across atherosclerotic rabbit aorta ex vivo by attenuated total reflection-Fourier transform infrared imaging. PubMed: In situ permeation study of drug through the stratum corneum using attenuated total reflectance [corrected] Fourier transform infrared spectroscopic imaging. PubMed: Enhancement of bioavailability by lowering of fat content in topical formulations. PubMed: Estimation of serum protein binding of compounds metabolized in serum using matrix inhibition. PubMed: Influence of nanosized delivery systems with benzyl nicotinate and penetration enhancers on skin oxygenation. PubMed: N-Benzyltetrahydropyrido-anellated thiophene derivatives: new anticholinesterases. PubMed: Kinetics of blood flow after topical application of benzyl nicotinate on different anatomic sites. PubMed: Comparison of blood flow to the cutaneous temperature and redness after topical application of benzyl nicotinate. PubMed: In vivo study of liposomes as drug carriers to oral mucosa using EPR oximetry. PubMed: In vivo study of different ointments for drug delivery into oral mucosa by EPR oximetry. PubMed: Skin oxygenation after topical application of liposome-entrapped benzyl nicotinate as measured by EPR oximetry in vivo: influence of composition and size. PubMed: Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo. PubMed: Different effects of 4-(4'-chlorobenzyloxy)benzoic acid (MII) on lipid synthesis and cell growth in human and mouse skin fibroblasts. PubMed: Effect of 4-(4'-chlorobenzyloxy)benzyl nicotinate (KCD-232) on cholesterol metabolism in rats. PubMed: Effect of KCD-232, a new hypolipidemic agent, on serum lipoprotein changes in hepatoma-bearing rats. PubMed: [Experimental nephrotic hyperlipidemia induced in rats by daunorubicin and effects of KCD-232[4-(4'-chlorobenzyloxy)benzyl nicotinate] on lipid metabolism]. PubMed: Percutaneous absorption in man: a kinetic approach. PubMed: Effect of 4-(4'-chlorobenzyloxy)benzyl nicotinate (KCD-232) on triglyceride and fatty acid metabolism in rats. PubMed: [Effects of 4-(4'-chlorobenzyloxy) benzyl nicotinate (KCD-232) on lipid metabolism in rats and mice]. PubMed: [Treatment of painful muscular disorders of various degrees of severity. Comparison of 2 new suppository preparations]. PubMed: [Short-term therapy of painful muscular disorders. Results of a multicenter double-blind test of 2 new suppository preparations with and without codeine]. PubMed: [Increased effectiveness of high-dose salicylate cream by iontophoresis]. PubMed: Effect of benzyl nicotinate on the percutaneous absorption of dexamethasone in the rat.