cetalkonium chloride

benzenemethanaminium, N-hexadecyl-N,N-dimethyl-, chloride (1:1)

CAS: 122-18-9 C25 H46 Cl N MW: 396.10062000

Identification

Namecetalkonium chloride
CAS Number122-18-9
EINECS204-526-3
FDA UNII85474O1N9D
Molecular FormulaC25 H46 Cl N
Molecular Weight396.10062000
MDL NumberMFCD00011625
Beilstein3802341

Regulatory

FDA Mainterm (SATF)122-18-9 ; QUATERNARY AMMONIUM CHLORIDE COMBINATION
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 59.00 °C. @ 760.00 mm Hg
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) 3.417 (est)
Soluble in water, 0.2147 mg/L @ 25 °C (est)
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD > 500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial preservatives
Recommendation for cetalkonium chloride usage levels up tonot for fragrance use.
Recommendation for cetalkonium chloride flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

acetoquat CDAC acquat CDAC ammonium, benzyldimethylhexadecyl-, chloride ammonium, benzylhexadecyldimethyl-, chloride ammonyx T benzenemethanaminium, N-hexadecyl-N,N-dimethyl-, chloride benzenemethanaminium, N-hexadecyl-N,N-dimethyl-, chloride (1:1) benzyl cetyl dimethyl ammonium chloride monohydrate benzyl-hexadecyl-dimethylazanium chloride N- benzyl-N-cetyldimethylammonium chloride benzyl-N-hexadecyldimethyl ammonium chloride N- benzyl-N,N-dimethyl-1-hexadecanaminium chloride N- benzyl-N,N-dimethylhexadecan-1-aminium chloride benzylcetyldimethylammonium chloride benzylcetyldimethylammonium chloride hydrate benzyldimethyl-N-hexadecylammonium chloride benzyldimethylcetylammonium chloride benzyldimethylhexadecylammonium chloride benzylhexadecyldimethylammonium chloride cetyl dimethyl benzyl ammonium chloride cetyl zephiran cetylbenzyldimethylammonium chloride cetyldimethylbenzylammonium chloride cetylon dehyquart CBB dimethylbenzylcetylammonium chloride dimethylbenzylhexadecylammonium chloride hexadecyl benzyl dimethyl ammonium chloride hexadecyl dimethyl benzyl ammonium chloride N- hexadecyl-N-benzyl-N,N-dimethylammonium chloride N- hexadecyl-N,N-dimethylbenzenemethanaminium chloride hexadecylbenzyldimethylammonium chloride hexadecyldimethylbenzylamine, chloride hexadecyldimethylbenzylammonium chloride N- hexadecyldimethylbenzylammonium chloride PubMed: Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. PubMed: Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. PubMed: Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery. PubMed: Extended delivery of an anionic drug by contact lens loaded with a cationic surfactant. PubMed: Cationic detergents enable the separation of membrane proteins of Plasmodium falciparum-infected erythrocytes by 2D gel electrophoresis. PubMed: A nano-confined charged layer defies the principle of electrostatic interaction. PubMed: Two-dimensional separation of membrane proteins by 16-BAC-SDS-PAGE. PubMed: 16-BAC/SDS-PAGE analysis of membrane proteins of yeast mitochondria purified by free flow electrophoresis. PubMed: Effects of preparation and experimental conditions on removal of phenol by surfactant-modified zeolites. PubMed: Copper and quaternary ammonium cations exert synergistic bactericidal and antibiofilm activity against Pseudomonas aeruginosa. PubMed: Reduction of quaternary ammonium-induced ocular surface toxicity by emulsions: an in vivo study in rabbits. PubMed: Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry. PubMed: Evaluation of two proteomics technologies used to screen the membrane proteomes of wild-type Corynebacterium glutamicum and an L-lysine-producing strain. PubMed: Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. PubMed: Enrichment of integral membrane proteins from small amounts of brain tissue. PubMed: Release characteristics of anionic drug compounds from liquid crystalline gels. Part II. The effects of ion pairing and buffering on the passive delivery of anionic drugs across non-rate-limiting membranes. PubMed: Occupational contact dermatitis to Mikrobac Extra in 8 hospital cleaners. PubMed: Influence of absorption enhancers on the pharmacokinetic properties of non-oral beta-lactam-cefpirom using the rabbit (Chinchilla) in vivo model. PubMed: A new multiphasic buffer system for benzyldimethyl-n-hexadecylammonium chloride polyacrylamide gel electrophoresis of proteins providing efficient stacking. PubMed: Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. PubMed: Two-dimensional benzyldimethyl-n-hexadecylammonium chloride/SDS-PAGE for membrane proteomics. PubMed: The synaptic vesicle proteome: a comparative study in membrane protein identification. PubMed: Investigation of the effects of wall adsorption of the visualization agent on baseline noise characteristics for indirect UV detection in capillary electrophoresis. PubMed: The trouble with teething--misdiagnosis and misuse of a topical medicament. PubMed: Occupational allergic contact dermatitis from alkylammonium amidobenzoate. PubMed: Urticaria and hidden salicylates. PubMed: 16-BAC/SDS-PAGE: a two-dimensional gel electrophoresis system suitable for the separation of integral membrane proteins. PubMed: Proliferation of mast cells in the smooth muscle of denervated rat jejunum. PubMed: Isolation and partial characterization of the outer dense fiber proteins from human spermatozoa. PubMed: Two dimensional benzyldimethyl-n-hexadecylammonium chloride----sodium dodecyl sulfate preparative polyacrylamide gel electrophoresis: a high capacity high resolution technique for the purification of proteins from complex mixtures. PubMed: Development of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals. PubMed: Use of benzyldimethyl-n-hexadecylammonium chloride ("16-BAC"), a cationic detergent, in an acidic polyacrylamide gel electrophoresis system to detect base labile protein methylation in intact cells. PubMed: [Analgesic efficacy of a gel combining choline salicylate and cetalkonium chloride on various mouth ulcerations]. PubMed: Bonjela therapy in oral lichen planus: a case report.