betamethasone
(11b,16b)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Identification
| Name | betamethasone |
| IUPAC | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| CAS Number | 378-44-9 |
| EINECS | 206-825-4 |
| FDA UNII | 9842X06Q6M |
| Molecular Formula | C22 H29 F O5 |
| Molecular Weight | 392.46753320 |
| MDL Number | MFCD00062969 |
| Nikkaji Number | J2.038I |
| Beilstein | 3176546 |
| XlogP3 | 1.90 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 232.00 °C. @ 760.00 mm Hg |
| Boiling Point | 568.23 °C. @ 760.00 mm Hg (est) |
| Flash Point | 567.00 °F. TCC ( 297.50 °C. ) (est) |
| logP (o/w) | 1.940 |
| Soluble in | water, 75.14 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD50 > 4500 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for betamethasone usage levels up to | not for fragrance use. |
| Recommendation for betamethasone flavor usage levels up to | not for flavor use. |
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Glentham Life Sciences Ltd
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Potential Uses
Natural Occurrence
Synonyms
betaderm
betametasone
betamethasonum
betatrex
celestone
b-
corlan
dermabet
diprolene
(8S,9R,10S,11S,13S,14S,16S,17R)-9-
fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
(11b,16b)-9-
fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
lotrisone
b-
methasone
b-
methasone alcohol
pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16b)-
PubMed:
Monitoring of 35 illegally added steroid compounds in foods and dietary supplements.
PubMed:
Olanzapine and Betamethasone Are Effective for the Treatment of Nausea and Vomiting due to Metastatic Brain Tumors of Rectal Cancer.
PubMed:
Validation of a liquid chromatography method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring.
PubMed:
Fast and multiresidue determination of twenty glucocorticoids in bovine milk using ultra high performance liquid chromatography-tandem mass spectrometry.
PubMed:
Validation of a recombinant cell bioassay for the detection of (gluco)corticosteroids in feed.
PubMed:
Simultaneous determination of eight corticosteroids in bovine tissues using liquid chromatography-tandem mass spectrometry.
PubMed:
Detection and quantitative analysis of 21 veterinary drugs in river water using high-pressure liquid chromatography coupled to tandem mass spectrometry.
PubMed:
Prescription drug use in pregnancy: a retrospective, population-based study in British Columbia, Canada (2001-2006).
PubMed:
[Detection of glucocorticoids by pressurized capillary electrochromatography with ultra-violet detection and its application in hair analysis].
PubMed:
Validation of a multi-residue enzyme-linked immunosorbent assay for qualitative screening of corticosteroids in liver, urine and milk.
PubMed:
Recombinant cell bioassays for the detection of (gluco)corticosteroids and endocrine-disrupting potencies of several environmental PCB contaminants.
PubMed:
Development of a liquid chromatography-tandem mass spectrometry with pressurized liquid extraction for determination of glucocorticoid residues in edible tissues.
PubMed:
Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken.
PubMed:
Cluster headache.
PubMed:
Seborrhoeic dermatitis.
PubMed:
Allergy-induced preterm labor after the ingestion of shellfish.
PubMed:
Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study.
PubMed:
The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species.
PubMed:
Optimization of solid phase extraction clean up and validation of quantitative determination of corticosteroids in urine by liquid chromatography-tandem mass spectrometry.
PubMed:
Hypersensitivity reaction to the ingestion of mango flesh.
PubMed:
Cluster headache.
PubMed:
Rapid multi-residue method for the quantitative determination and confirmation of glucocorticosteroids in bovine milk using liquid chromatography-electrospray ionization-tandem mass spectrometry.
PubMed:
Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry.
PubMed:
Seborrhoeic dermatitis.
PubMed:
Detection of synthetic corticosteroids in bovine urine by chemiluminescence high-performance liquid chromatography.
PubMed:
Pediatric drug labeling: improving the safety and efficacy of pediatric therapies.
PubMed:
Effect of betamethasone on maternal glucose.
PubMed:
Betamethasone valerate foam for treatment of nonscalp psoriasis.
PubMed:
Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections.
PubMed:
Differentiation between dexamethasone and betamethasone in a mixture using multiple mass spectrometry.
PubMed:
Simultaneous determination of betamethasone and dexamethasone residues in bovine liver by liquid chromatography/tandem mass spectrometry.
PubMed:
Chemiluminescence detection of nine corticosteroids in liver.
PubMed:
Suppression of food intake is linked to enteric inflammation in nematode-infected rats.
PubMed:
Effects of Kakkon-to and Sairei-to on experimental elevation of aqueous flare in pigmented rabbits.
PubMed:
Evaluation of the test system used for in vitro release of drugs for topical dermatological drug products.
PubMed:
Assessment of pain during locomotion and the welfare of adult male turkeys with destructive cartilege loss of the hip joint.
PubMed:
Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model.
PubMed:
Identification of main corticosteroids as illegal feed additives in milk replacers by liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry.
PubMed:
Factors associated with growth of extremely premature infants during initial hospitalization.
PubMed:
Evaluation of the proposed FDA pilot dose-response methodology for topical corticosteroid bioequivalence testing.
PubMed:
Assessment of the welfare of food restricted male broiler breeder poultry with musculoskeletal disease.
PubMed:
Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs.
PubMed:
Topical corticosteroids: quality control considerations.
PubMed:
Relationship between in vivo skin blanching and in vitro release rate for betamethasone valerate creams.
PubMed:
[A case of asthma exacerbated by sulfite contained in betamethasone].
PubMed:
[Iatrogenic Cushing syndrome in infants. Report of a case with dwarfism].
PubMed:
Stability of betamethasone sodium phosphate, hydrocortisone sodium phosphate, and prednisolone sodium phosphate injections submitted by U.S. hospitals.
PubMed:
Stability of sterile aqueous epinephrine injections submitted by U.S. hospitals.
PubMed:
Stability of sterile aqueous lidocaine hydrochloride and epinephrine injections submitted by U.S. hospitals.
PubMed:
The inhibitory effect of ketotifen on in vitro histamine release in allergic patients.
PubMed:
[Studies of toxicity of hydrocortisone 17-butyrate 21-propionate -5. Chronic toxicity in rats by percutaneous administration (author's transl)].
PubMed:
Drugs released for clinical use.
PubMed:
Corticosteroids in diseases of the oral mucosa.
PubMed:
[Periocically occurring aphthae].