betulinic acid
(3b)-3-hydroxylup-20(29)-en-28-oic acid
Identification
| Name | betulinic acid |
| CAS Number | 472-15-1 |
| EINECS | 207-448-8 |
| FDA UNII | 4G6A18707N |
| Molecular Formula | C30 H48 O3 |
| Molecular Weight | 456.71016000 |
| MDL Number | MFCD00009619 |
| Nikkaji Number | J11.885K |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 550.02 °C. @ 760.00 mm Hg (est) |
| Flash Point | 573.00 °F. TCC ( 300.50 °C. ) (est) |
| logP (o/w) | 7.653 (est) |
| Soluble in | water, 0.001607 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for betulinic acid usage levels up to | not for fragrance use. |
| Recommendation for betulinic acid flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Jiangyin Healthway International Trade Co., Ltd
Independent Ingredients Supplier
We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
Potential Uses
Natural Occurrence
Synonyms
betulic acid
betulinicacid
(3b)-3-
hydroxylup-20(29)-en-28-oic acid
PubMed:
Chemical Constituents of Gold-red Apple and Their α-Glucosidase Inhibitory Activities.
PubMed:
Molecular modeling of Ruellia tuberosa L compounds as a-amylase inhibitor: an in silico comparation between human and rat enzyme model.
PubMed:
Phytochemicals and antioxidant activities of Rhus tripartitum (Ucria) fruits depending on locality and different stages of maturity.
PubMed:
Contribution of phenolics and essential oils to the antioxidant and antimicrobial properties of Disporopsis pernyi (Hua) Diels.
PubMed:
Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells.
PubMed:
Chemical constituents of Rhododendron formosanum show pronounced growth inhibitory effect on non-small-cell lung carcinoma cells.
PubMed:
Beneficial Effect of Betulinic Acid on Hyperglycemia via Suppression of Hepatic Glucose Production.
PubMed:
Vitiquinolone--a quinolone alkaloid from Hibiscus vitifolius Linn.
PubMed:
Ethanol extract of Lycopus lucidus elicits positive inotropic effect via activation of Ca2+ entry and Ca2+ release in beating rabbit atria.
PubMed:
Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes.
PubMed:
Synthesis and cytotoxic activity of new betulin and betulinic acid esters with conjugated linoleic acid (CLA).
PubMed:
Caffeoyl triterpenes from pear (Pyrus pyrifolia Nakai) fruit peels and their antioxidative activities against oxidation of rat blood plasma.
PubMed:
Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway.
PubMed:
Unusual immuno-modulatory triterpene-caffeates in the skins of russeted varieties of apples and pears.
PubMed:
Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway.
PubMed:
Combined treatment of betulinic acid, a PTP1B inhibitor, with Orthosiphon stamineus extract decreases body weight in high-fat-fed mice.
PubMed:
Leptin: making it live up to its promise using natural products.
PubMed:
Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.
PubMed:
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.
PubMed:
Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity.
PubMed:
A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana.
PubMed:
Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.
PubMed:
Exploration of the antiplatelet activity profile of betulinic acid on human platelets.
PubMed:
Effect on tumor necrosis factor-α production and antioxidant ability of black alder, as factors related to its anti-inflammatory properties.
PubMed:
Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.
PubMed:
Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis.
PubMed:
Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
PubMed:
Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS.
PubMed:
Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia).
PubMed:
Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits.
PubMed:
Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells.
PubMed:
Isolation and structure determination of one new metabolite isolated from the red fermented rice of Monascus purpureus.
PubMed:
Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals.
PubMed:
Secondary plant substances in various extracts of the leaves, fruits, stem and bark of Caraipa densifolia Mart.
PubMed:
Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet.
PubMed:
Betulinic acid: a natural product with anticancer activity.
PubMed:
Triterpenic and other lipophilic components from industrial cork byproducts.
PubMed:
Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.
PubMed:
Four new prenylated isoflavonoids in Tadehagi triquetrum.
PubMed:
Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil.
PubMed:
Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities.
PubMed:
Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.
PubMed:
Identification of three triterpenoids in almond hulls.