diethyl hexyl adipate

adipic acid, bis(2-ethylhexyl) ester

CAS: 103-23-1 C22 H42 O4 MW: 370.57354000

Identification

Namediethyl hexyl adipate
IUPACbis(2-ethylhexyl) hexanedioate
CAS Number103-23-1
EINECS203-090-1
FDA UNIIMBY1SL921L
Molecular FormulaC22 H42 O4
Molecular Weight370.57354000
MDL NumberMFCD00009496
Nikkaji NumberJ3.602A
Beilstein1803774

Regulatory

DG SANTE Food Contact Materialsadipic acid, bis(2-ethylhexyl) ester
FDA Mainterm (IAUFC)103-23-1 ; DI(2-ETHYLHEXYL) ADIPATE
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.92400 to 0.93100 @ 25.00 °C.
Pounds per Gallon - (est). 7.689 to 7.747
Refractive Index 1.43900 to 1.45700 @ 20.00 °C.
Melting Point -67.80 °C. @ 760.00 mm Hg
Boiling Point 416.00 to 418.00 °C. @ 760.00 mm Hg, 166.00 to 168.00 °C. @ 1.00 mm Hg
Flash Point 336.00 °F. TCC ( 168.89 °C. )
logP (o/w) 7.771 (est)
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfilm formers

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityintravenous-rat LD50 900 mg/kg
Dermal Toxicityskin-rabbit LD50 16 mL/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysolvents/deluents for cosmetic, flavor and/or fragrance agents
Recommendation for diethyl hexyl adipate usage levels up tonot for fragrance use.
Recommendation for diethyl hexyl adipate flavor usage levels up tonot for flavor use.

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Potential Uses

emollients film formers plasticisers skin conditioning solvents

Natural Occurrence

not found in nature

Synonyms

adipic acid bis(2-ethyl hexyl) ester adipic acid bis(2-ethylhexyl) ester adipic acid di-2-ethylhexyl ester adipic acid di(2-ethylhexyl) ester adipic acid, bis(2-ethylhexyl) ester arlamol DOA bisoflex DOA crodamol DOA dermol DOA di octyl adipate di-(2-ethylhexyl) adipate di-2-ethylhexyl adipate di(2-ethyl hexyl) adipate di(2-ethylhexyl) adipate di(2-ethylhexyl)adipate di2-ethylhexyl hexane-1,6-dioate dioctyl adipate (so called) DOA plasticizer, kosher effomoll DOA ergoplast ADDO bis(2- ethyl hexyl) adipate bis(2- ethyl hexyl) hexane dioate bis(2- ethylhexyl) adipate bis(2- ethylhexyl) hexanedioate bis(2- ethylhexyl)adipate flexol A 26 hatcol 2908 hexane dioic acid bis(2-ethyl hexyl) ester hexanedioic acid bis(2-ethylhexyl) ester hexanedioic acid, 1,6-bis(2-ethylhexyl) ester hexanedioic acid, bis(2-ethylhexyl) ester jayflex DOA 2 kodaflex DOA lankroflex DOA lubricit DOA-W monoplex DOA morflex 310 octyl adipate plasthall DOA plastomoll DOA reomol DOA sansocizer DOA songcizer DOA staflex DOA truflex DOA uniplex 125-A vestinol OA vistone A 10 wickenol 158 witamol 320 PubMed: Di-(2-ethylhexyl) adipate in selected total diet food composite samples. PubMed: In vitro metabolites of di-2-ethylhexyl adipate (DEHA) as biomarkers of exposure in human biomonitoring applications. PubMed: Polythiophene-coated Fe3O4 superparamagnetic nanocomposite: synthesis and application as a new sorbent for solid-phase extraction. PubMed: In vitro dermal absorption of di(2-ethylhexyl) adipate (DEHA) in a roll-on deodorant using human skin. PubMed: Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan. PubMed: The effect of priming solutions and storage time on plasticizer migration in different PVC tubing types--implications for wet storage of ECMO systems. PubMed: Comparison of solidification of floating drop and homogenous liquid-liquid microextractions for the extraction of two plasticizers from the water kept in PET-bottles. PubMed: Collaborative work on evaluation of ovarian toxicity. 9) Effects of 2- or 4-week repeated dose studies and fertility study of di(2-ethylhexyl)adipate (DEHA) in female rats. PubMed: Application of artificial neural network for yield prediction of lipase-catalyzed synthesis of dioctyl adipate. PubMed: Aqueous solubility and Daphnia magna chronic toxicity of di(2-ethylhexyl) adipate. PubMed: The debittering of navel orange juice using polymeric films. PubMed: Plasticizers and their degradation products in the process streams of a large urban physicochemical sewage treatment plant. PubMed: Trace phthalate and adipate esters contaminated in packaged food. PubMed: Migration of di(2-ethylhexyl) adipate and acetyltributyl citrate plasticizers from food-grade PVC film into sweetened sesame paste (halawa tehineh): kinetic and penetration study. PubMed: Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative. PubMed: Considerations on ultra-trace analysis of phthalates in drinking water. PubMed: Fungal colonization of soil-buried plasticized polyvinyl chloride (pPVC) and the impact of incorporated biocides. PubMed: Extractables/leachables from plastic tubing used in product manufacturing. PubMed: Plasticizers in Brazilian food-packaging materials acquired on the retail market. PubMed: Metabolites from the biodegradation of di-ester plasticizers by Rhodococcus rhodochrous. PubMed: Amodiaquine polymeric membrane electrode. PubMed: Dietary exposure to chemical migrants from food contact materials: a probabilistic approach. PubMed: Early testicular effects in rats perinatally exposed to DEHP in combination with DEHA--apoptosis assessment and immunohistochemical studies. PubMed: Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate. PubMed: DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity. PubMed: Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats. PubMed: Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease. PubMed: Direct analysis of plasticizers in aqueous samples by atmospheric pressure chemical ionization-tandem mass spectrometry (APCI-MS-MS). PubMed: Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. PubMed: Supercritical fluid extraction of potential migrants from paper and board intended for use as food packaging materials. PubMed: [Contents of phthalate in polyvinyl chloride toys]. PubMed: Eleven phthalate esters and di(2-ethylhexyl) adipate in one-week duplicate diet samples obtained from hospitals and their estimated daily intake. PubMed: Effect of Dodecyl Alcohol on the Potentiometric Response of an Isopropyl Xanthate Ion-Selective Electrode. PubMed: Di(2-ethylhexyl) adipate. PubMed: Migration of di-(2-ethylhexylexyl)adipate plasticizer from food-grade polyvinyl chloride film into hard and soft cheeses. PubMed: Fungal colonization and biodeterioration of plasticized polyvinyl chloride. PubMed: Plasticizers in total diet samples, baby food and infant formulae. PubMed: Plasticizers increase adhesion of the deteriogenic fungus Aureobasidium pullulans to polyvinyl chloride. PubMed: Specific migration of di-(2-ethylhexyl)adipate (DEHA) from plasticized PVC film: results from an enforcement campaign. PubMed: Effect of high-dose electron beam irradiation on the migration of DOA and ATBC plasticizers from food-grade PVC and PVDC/PVC films, respectively, into olive oil. PubMed: Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. PubMed: Specific migration testing with alternative fatty food simulants. PubMed: Comparison of the effects of di-(2-ethylhexyl)adipate on hepatic peroxisome proliferation and cell replication in the rat and mouse. PubMed: Migration from PVC cling films compared with their field of application. PubMed: Effect of microwave heating on the migration of dioctyladipate and acetyltributylcitrate plasticizers from food-grade PVC and PVDC/PVC films into olive oil and water. PubMed: Migration of dioctyladipate plasticizer from food-grade PVC film into chicken meat products: effect of gamma-radiation. PubMed: Effect of gamma-radiation on migration behaviour of dioctyladipate and acetyltributylcitrate plasticizers from food-grade PVC and PVDC/PVC films into olive oil. PubMed: PVC cling film in contact with cheese: health aspects related to global migration and specific migration of DEHA. PubMed: The occurrence of phthalate ester and di-2-ethylhexyl adipate plasticizers in Canadian packaging and food sampled in 1985-1989: a survey. PubMed: Evaluation of an ammonium ionophore for use in poly(vinyl chloride) membrane ion-selective electrodes: solvent mediator effects. PubMed: An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study. PubMed: Metabolism and pharmacokinetics of deuterium-labelled di-2-(ethylhexyl) adipate (DEHA) in humans. PubMed: Genotoxic effects of selected peroxisome proliferators. PubMed: Migration of polyisobutylene from polyethylene/polyisobutylene films into foods during domestic and microwave oven use. PubMed: Microsomal lauric acid hydroxylase activities after treatment of rats with three classical cytochrome P450 inducers and peroxisome proliferating compounds. PubMed: Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate and species differences in response. PubMed: Chamber and gavage technique for metabolic studies of earthworms. PubMed: Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid. PubMed: Non-mutagenicity of 4 metabolites of di(2-ethylhexyl)phthalate (DEHP) and 3 structurally related derivatives of di(2-ethylhexyl)adipate (DEHA) in the Salmonella mutagenicity assay. PubMed: Plasticizer migration in foods. PubMed: Migration testing of plastics and microwave-active materials for high-temperature food-use applications. PubMed: Evaluation of a predictive mathematical model of di-(2-ethylhexyl) adipate plasticizer migration from PVC film into foods. PubMed: Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate. PubMed: Migration from plasticized films into foods. 2. Migration of di-(2-ethylhexyl)adipate from PVC films used for retail food packaging. PubMed: Migration from plasticized films into foods. 1. Migration of di-(2-ethylhexyl)adipate from PVC films during home-use and microwave cooking. PubMed: Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters. PubMed: Alteration of hepatic phospholipids in rats and mice by feeding di-(2-ethylhexyl)adipate and di-(2-ethylhexyl)phthalate. PubMed: Safety evaluation of a barrier cream. PubMed: Di-(2-ethylhexyl)adipate: absorption, autoradiographic distribution and elimination in mice and rats. PubMed: Indirect food additive migration from polymeric food packaging materials. PubMed: In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators. PubMed: Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug. PubMed: Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships. PubMed: Comparative chronic toxicities and carcinogenic potentials of 2-ethylhexyl-containing compounds in rats and mice. PubMed: Investigation of the potential for binding of Di(2-ethylhexyl) phthalate (DEHP) and Di(2-ethylhexyl) adipate (DEHA) to liver DNA in vivo. PubMed: Induction of rat hepatic long-chain acyl-CoA hydrolases by various peroxisome proliferators. PubMed: Genotoxicity studies on di-(2-ethylhexyl) phthalate and adipate and toxicity studies on di-(2-ethylhexyl) phthalate in the rat and marmoset. PubMed: Di(2-ethylhexyl)adipate (DEHA): effect on plasma lipids and hepatic cholesterolgenesis in the rat. PubMed: Effects of peroxisome proliferators on fatty acid-binding protein in rat liver. PubMed: Induction of microsomal stearoyl-CoA desaturation by the administration of various peroxisome proliferators. PubMed: Effect of the plasticizer di(2-ethylhexyl) adipate (dioctyladipate, DOA) on lipid metabolism in the rat: I. Inhibition of cholesterolgenesis and modification of phospholipid synthesis. PubMed: Evaluation of emissions from simulated commercial meat wrapping operations using PVC wrap. PubMed: Condensations of the Carcinogenesis Bioassay Technical Reports. PubMed: Di(2-ethylhexyl) adipate. PubMed: Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CAS No. 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study). PubMed: A potassium-selective electrode with solid internal contact. PubMed: Plasticizer migration from polyvinyl chloride film to solvents and foods. PubMed: Elimination, distribution and metabolism of di-(2-ethylhexyl)adipate (DEHA) in rats. PubMed: [Hygienic chemical studies on polyvinyl chloride (V). Migration of plasticizer from soft polyvinyl chloride used for food packaging (author's transl)].