bromochloromethane
methylene bromochloride
Identification
| Name | bromochloromethane |
| IUPAC | bromo(chloro)methane |
| CAS Number | 74-97-5 |
| EINECS | 200-826-3 |
| FDA UNII | 45WX84110G |
| Molecular Formula | C H2 Br Cl |
| Molecular Weight | 129.38294000 |
| MDL Number | MFCD00000880 |
| Nikkaji Number | J2.384A |
| Beilstein | 1730801 |
Regulatory
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.99100 @ 25.00 °C. |
| Boiling Point | 68.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 143.000000 mmHg @ 25.00 °C. (est) |
| Flash Point | -9.00 °F. TCC ( -22.90 °C. ) (est) |
| logP (o/w) | 1.410 |
| Soluble in | water, 1.67E+04 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD50 4300 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 20000 mg/kg |
| Inhalation Toxicity | inhalation-mouse LC50 12030 mg/m3/7H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: GENERAL ANESTHETIC\nBEHAVIORAL: TREMOR']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for bromochloromethane usage levels up to | not for fragrance use. |
| Recommendation for bromochloromethane flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
bromo(chloro)methane
mono
bromomonochloromethane
chloromethyl bromide
fluorocarbon 1011
methane, bromochloro-
methylene bromochloride
PubMed:
[Influences of high-fat diet and methanogens inhibitor on the cecal microbiota and fat metabolism in C57BL/6J mice].
PubMed:
An antimethanogenic nutritional intervention in early life of ruminants modifies ruminal colonization by Archaea.
PubMed:
Improving pulsed radiofrequency glow discharge for time-of-flight mass spectrometry simultaneous elemental and molecular analysis.
PubMed:
In vitro-in vivo study on the effects of plant compounds on rumen fermentation, microbial abundances and methane emissions in goats.
PubMed:
Nutritional intervention in early life to manipulate rumen microbial colonization and methane output by kid goats postweaning.
PubMed:
Effect of bromochloromethane and fumarate on phylogenetic diversity of the formyltetrahydrofolate synthetase gene in bovine rumen.
PubMed:
Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats.
PubMed:
Effect of bromochloromethane on methane emission, rumen fermentation pattern, milk yield, and fatty acid profile in lactating dairy goats.
PubMed:
Responses in digestion, rumen fermentation and microbial populations to inhibition of methane formation by a halogenated methane analogue.
PubMed:
Tuneable microsecond-pulsed glow discharge design for the simultaneous acquisition of elemental and molecular chemical information using a time-of-flight mass spectrometer.
PubMed:
Inhibition of methanogens by bromochloromethane: effects on microbial communities and rumen fermentation using batch and continuous fermentations.
PubMed:
Synthesis of nanoscale carceplexes from deep-cavity cavitands.
PubMed:
Isobaric and isochoric freezing of CH2BrCl and isostructural relations between CH2Cl2, CH2Br2 and CH2BrCl.
PubMed:
Quantitation and diversity analysis of ruminal methanogenic populations in response to the antimethanogenic compound bromochloromethane.
PubMed:
Combined vacuum ultraviolet laser and synchrotron pulsed field ionization study of CH2BrCl.
PubMed:
On the location of conical intersections in CH2BrCl using MS-CASPT2 methods.
PubMed:
Metabolism of mono- and dihalogenated C1 and C2 compounds by Xanthobacter autotrophicus growing on 1,2-dichloroethane.
PubMed:
Reduction of greenhouse gases from anaerobic piggery wastewater treatment by bromochloromethane in Taiwan.
PubMed:
Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra.
PubMed:
Detection limits for time-resolved coherent two-dimensional vibrational spectroscopy.
PubMed:
Correlations of Henry's Law Gas-Solid Virial Coefficients and Chromatographic Retention Times for Hydrocarbons and Halocarbons Adsorbed on Carbopack C Carbon.
PubMed:
Predicting vehicle effects on the dermal absorption of halogenated methanes using physiologically based modeling.
PubMed:
Physiologically based modeling of nonsteady state dermal absorption of halogenated methanes from an aqueous solution.
PubMed:
Preparation of Aminoalkyl Chlorohydrin Hydrochlorides: Key Building Blocks for Hydroxyethylamine-Based HIV Protease Inhibitors.
PubMed:
Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
PubMed:
Quantitative structure-activity relationship models correctly predict the toxic and aneuploidizing properties of six halogenated methanes in Aspergillus nidulans.
PubMed:
Effect of isoniazid or phenobarbital pretreatment on the metabolism of dihalomethanes to carbon monoxide.
PubMed:
Dermal absorption of neat and aqueous volatile organic chemicals in the Fischer 344 rat.
PubMed:
Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.
PubMed:
Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation.
PubMed:
Damage to protein synthesis concurrent with lipid peroxidation in rat liver slices: effect of halogenated compounds, peroxides, and vitamin E1.
PubMed:
Synthesis and oral antifungal activity of novel azolylpropanolones and related compounds.
PubMed:
Halogenated compounds as inducers of lipid peroxidation in tissue slices.
PubMed:
A physiologically based simulation approach for determining metabolic constants from gas uptake data.
PubMed:
A physiological pharmacokinetic model for dermal absorption of vapors in the rat.
PubMed:
Dermal absorption of dihalomethane vapors.
PubMed:
Chemical reactivity and mutagenicity of some dihalomethanes.
PubMed:
The inhalation toxicity of pyrolysis products of bromochloromethane (CH2BrCl) and bromotrifluoromethane (CBrF3).
PubMed:
Some solvent effects on the solvent extraction of 8-quinolinol.
PubMed:
The toxicity of bromochloromethane (methylene chlorobromide) as determined on laboratory animals.