brucine anhydrous

brucine (-)- brucine brucinum (1R,11S,18S,20R,21R,22S)-4,5- dimethoxy-12-oxa-8,17-diazaheptacyclo[15.5.2.01,18.02,7.08,22.011,21.015,20]tetracosa-2(7),3,5,14-tetraen-9-one monohydrate 2,3- dimethoxystrychnidin-10-one 10,11- dimethoxystrychnine 2,3- dimethoxystrychnine strychnidin-10-one, 2,3-dimethoxy- PubMed: Thermosensitive liposomes with higher phase transition temperature for targeted drug delivery to tumor. PubMed: Anticancer effects of brucine and gemcitabine combination in MCF-7 human breast cancer cells. PubMed: Capillary Coated with Graphene Oxide as Stationary Phase for the Separation of Brucine and Strychnine by Capillary Electrophoresis. PubMed: [Inducing-apoptosis effect of brucine on human monocytic leukemia cell line THP-1 and its mechanism]. PubMed: [Brucine inhibits the proliferation of human lung cancer cell line PC-9 
via arresting cell cycle]. PubMed: Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine. PubMed: Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats. PubMed: Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes. PubMed: Theoretical investigations into spectral and non-linear optical properties of brucine and strychnine using density functional theory. PubMed: Rapid separation and identification of Strychnos alkaloids metabolites in rats by ultra high performance liquid chromatography with linear ion trap Orbitrap mass spectrometry. PubMed: Preparation of surface-imprinted polymer grafted with water-compatible external layer via RAFT precipitation polymerization for highly selective and sensitive electrochemical determination of brucine. PubMed: Suppression of spectral anomalies in SSFP-NMR signal by the Krylov Basis Diagonalization Method. PubMed: Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents. PubMed: Enantiopure o-ethyl phenylphosphonothioic Acid: a solvating agent for the determination of enantiomeric excesses. PubMed: A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats. PubMed: On-line two-step stacking in capillary zone electrophoresis for the preconcentration of strychnine and brucine. PubMed: Metabolism of brucine: the important metabolic pathways of dihydroindole-type alkaloid for excretion in rats. PubMed: Simultaneous detection of 22 toxic plant alkaloids (aconitum alkaloids, solanaceous tropane alkaloids, sophora alkaloids, strychnos alkaloids and colchicine) in human urine and herbal samples using liquid chromatography-tandem mass spectrometry. PubMed: Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection. PubMed: Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine. PubMed: Hyaluronic acid-coated bovine serum albumin nanoparticles loaded with brucine as selective nanovectors for intra-articular injection. PubMed: Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats. PubMed: Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway. PubMed: Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway. PubMed: [Optimization and application of method to determine plasma concentration of brucine]. PubMed: HPLC-DAD method for comprehensive quality control of Semen Strychni. PubMed: Dynamic detection of non-protein-bound strychnine and brucine in rabbit muscle and synovial fluid after topical application of total Strychnos alkaloid patches. PubMed: Screening calmodulin-binding ligands using intensity-fading matrix-assisted laser desorption/ionization mass spectrometry. PubMed: In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates. PubMed: Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells. PubMed: Validated UPLC-MS/MS method for determination of moclobemide in human brain cell supernatant and its application to bidirectional transport study. PubMed: Brucine-loaded liposomes composed of HSPC and DPPC at different ratios: in vitro and in vivo evaluation. PubMed: Evaluation of the pharmacodynamics and pharmacokinetics of brucine following transdermal administration. PubMed: Study of receptor mediated selective anion transmembrane transport using parallel artificial membrane permeability assay. PubMed: Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo. PubMed: In vitro metabolism study of Strychnos alkaloids using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. PubMed: [Preparation and pharmacokinetics of brucine hydrogel patch]. PubMed: Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor. PubMed: Effect of alkyl chain length of alcohols on cholesteric uniaxial to cholesteric biaxial phase transitions in a potassium laurate/alcohol/potassium sulfate/water/brucine lyotropic mixture: evidence of a first-order phase transition. PubMed: Strychnos nux-vomica root extract induces apoptosis in the human multiple myeloma cell line-U266B1. PubMed: [LC-MS/MS analysis of determination of strychnine and brucine in formaldehyde fixed tissue]. PubMed: Brucine induces the apoptosis of U266 multiple myeloma cells by phosphorylation of c-Jun. PubMed: In-vivo and In-vitro activities of medicinal plants on ecto, endo and haemoparasitic infections: a review. PubMed: [Comparison on in vivo pharmacokinetics of brucine, total alkaloids of Strychni Semen and Strychni Semen pulveratum in rats]. PubMed: Fixing latent fingermarks developed by iodine fuming: a new method. PubMed: Rituals can kill - A fatal case of brucine poisoning. PubMed: Simultaneous determination of six toxic alkaloids in human plasma and urine using capillary zone electrophoresis coupled to time-of-flight mass spectrometry. PubMed: Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration. PubMed: Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine. PubMed: Effects of brucine on vascular endothelial growth factor expression and microvessel density in a nude mouse model of bone metastasis due to breast cancer. PubMed: [Brucine chitosan thermosensitive hydrogel for intra-articular injection]. PubMed: [Effect of NF-kappaB on inhibition of non-small cell lung cancer cell cyclooxygenase-2 by brucine]. PubMed: Influence of P-glycoprotein on brucine transport at the in vitro blood-brain barrier. PubMed: [Determination of brucine and strychnine in rat after cutaneous administration of semen strychni niosome gel by LC-MS/MS]. PubMed: Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity. PubMed: Effects of brucine on bone metabolism in multiple myeloma. PubMed: Simultaneous HPTLC determination of strychnine and brucine in strychnos nux-vomica seed. PubMed: Effect of Shodhana (processing) on Kupeelu (Strychnos nux-vomica Linn.) with special reference to strychnine and brucine content. PubMed: Safety of individual medication of Ma Qian Zi (semen strychni) based upon assessment of therapeutic effects of Guo's therapy against moderate fluorosis of bone. PubMed: Simultaneous analysis of strychnine and brucine and their major metabolites by liquid chromatography-electrospray ion trap mass spectrometry. PubMed: Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma. PubMed: [Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases]. PubMed: Effect of purificatory measures through cow's urine and milk on strychnine and brucine content of Kupeelu (Strychnos nuxvomica Linn.) seeds. PubMed: The interaction of blood proteins with brucine. PubMed: Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition. PubMed: Pharmacokinetics of brucine after intravenous and oral administration to rats. PubMed: Ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of strychnine and brucine in mice plasma. PubMed: [Pharmacokinetics of brucine in rats after intravenous administration of liposomes containing total alkaloids from seed of Strychnos nux-vomica]. PubMed: 2,3-dimethoxy-10-oxostrychnidinium 2-(2,4,6-trinitroanilino)benzoate monohydrate: a 1:1 proton-transfer salt of brucine with o-picraminobenzoic acid. PubMed: Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo. PubMed: Preparation, characterization and tissue distribution of brucine stealth liposomes with different lipid composition. PubMed: A computational study on the role of chiral N-oxides in enantioselective Pauson-Khand reactions. PubMed: [Effect of phospholipid composition on pharmaceutical properties and anti-tumor activity of stealth liposomes containing brucine]. PubMed: [Apoptosis-inducing effects of brucine on human chronic myeloid leukemia cell line K562]. PubMed: Study of pharmacokinetics and tissue distribution of liposomal brucine for dermal administration. PubMed: Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line. PubMed: A new method for the simultaneous analysis of strychnine and brucine in Strychnos nux-vomica unprocessed and processed seeds using a carbon-paste electrode modified with multi-walled carbon nanotubes. PubMed: Inhibition of human Na(v)1.5 sodium channels by strychnine and its analogs. PubMed: HPLC determination of strychnine and brucine in rat tissues and the distribution study of processed semen strychni. PubMed: [Effect of brucine on secretion function and proliferation capability of T lymphocytes in patients with aplastic anemia]. PubMed: [Effect of brucine on metabolism of osteoblasts and osteoclasts in multiple myeloma]. PubMed: Fatal intoxication due to brucine. PubMed: [Determination and comparison of plasma protein binding rate of alkaloids from seed of Strychnou nux-vomica]. PubMed: Importance of media in shodhana (purification / processing) of poisonous herbal drugs. PubMed: Simultaneous determination of six alkaloids in blood and urine using a hydrophilic interaction liquid chromatography method coupled with electrospray ionization tandem mass spectrometry. PubMed: Spectroscopic and physicochemical studies on organic crystal of brucine hydrogen maleate pentahydrate. PubMed: Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy. PubMed: Brucine N-oxide-catalyzed Morita-Baylis-Hillman reaction of vinyl ketones: a mechanistic implication of dual catalyst system with proline. PubMed: Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae. PubMed: [A comparative study on HPLC fingerprint of Semen Strychni and the processed]. PubMed: [Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles]. PubMed: Brucine-derived amino alcohol catalyzed asymmetric Henry reaction: an orthogonal enantioselectivity approach. PubMed: Death due to ingestion of nicotine-containing solution: case report and review of the literature. PubMed: Preparative resolution of etodolac enantiomers by preferential crystallization method. PubMed: Reversal of enantioselectivity between the copper(I)- and silver(I)-catalyzed 1,3-dipolar cycloaddition reactions using a brucine-derived amino alcohol ligand. PubMed: A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure. PubMed: Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composition on entrapment efficiency and physicochemical properties in vitro. PubMed: Rapid and sensitive determination of strychnine and brucine in human urine by capillary electrophoresis with field-amplified sample stacking. PubMed: Absolute configuration of 3,3'-diphenyl-[2,2'-binaphthalene]-1,1'-diol revisited. PubMed: A three-phase microfluidic chip for rapid sample clean-up of alkaloids from plant extracts. PubMed: Preparation and pharmaceutical/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel. PubMed: Intestinal permeability of antitumor alkaloids from the processed seeds of Strychnos nux-vomica in a Caco-2 cell model. PubMed: [Influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients]. PubMed: [Study on safety and pharmacodynamic action of transdermal liposomal brucine]. PubMed: [Strychnos alkaloids inhibit the proliferation of adult rat neuroprogenitor cells]. PubMed: [Pharmaceutical characteristics of brucine stealth liposomes]. PubMed: Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry. PubMed: Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line - RPMI 8226. PubMed: Construction and evaluation of ion selective electrodes for nitrate with a summing operational amplifier. Application to tobacco analysis. PubMed: Simultaneous determination of five toxic alkaloids in body fluids by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. PubMed: Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate. PubMed: [Study on transdermal absorption characteristics of brucine in vitro]. PubMed: Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC. PubMed: A simple method to identify the unprocessed Strychnos seeds used in herbal medicinal products. PubMed: Development and validation of a TLC-densitometric method for the simultaneous quantitation of strychnine and brucine from Strychnos spp. and its formulations. PubMed: Preparation of liposomal brucine and its pharmaceutical/pharmacodynamic characterization. PubMed: Analysis of Strychnos alkaloids in traditional Chinese medicines with improved sensitivity by sweeping micellar electrokinetic chromatography. PubMed: Pseudopolymorphism in brucine: brucine-water (1/2), the third crystal hydrate of brucine. PubMed: Application of high performance capillary electrophoresis on toxic alkaloids analysis. PubMed: Supramolecular tilt chirality in crystals of steroids and alkaloids. PubMed: [Study on the interaction between brucine and bovine serum albumin]. PubMed: [Paharmacological mechanisms of cellular immunity of overall alkali of tongbiling for the treatment of joint destruction]. PubMed: The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells. PubMed: Hollow fiber-based liquid-phase microextraction combined with on-line sweeping for trace analysis of Strychnos alkaloids in urine by micellar electrokinetic chromatography. PubMed: The effect of nifedipine on oral contraceptive-induced hypertension in rats. PubMed: Determinants of positive cooperativity between strychnine-like allosteric modulators and N-methylscopolamine at muscarinic receptors. PubMed: Electrochemical study of brucine on an electrode modified with magnetic carbon-coated nickel nanoparticles. PubMed: [Studies on quality control methods of nuxvomica]. PubMed: Diffusion coefficient distribution from NMR-DOSY experiments using Hopfield neural network. PubMed: Brucine salts of L-alpha-hydroxy acids: brucinium hydrogen (S)-malate pentahydrate and anhydrous brucinium hydrogen (2R,3R)-tartrate at 130 K. PubMed: Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors. PubMed: Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors. PubMed: Two pseudopolymorphic hydrates of brucine: brucine-water (1/4) and brucine-water (1/5.25) at 130 K. PubMed: Analysis of strychnos alkaloids using electrospray ionization Fourier transform ion cyclotron resonance multi-stage tandem mass spectrometry. PubMed: The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway. PubMed: The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism. PubMed: Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7. PubMed: Separation and determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation by nonaqueous capillary electrophoresis. PubMed: Rapid separation of strychnine and brucine on a dynamically modified poly(dimethylsiloxane) microchip followed by electrochemical detection. PubMed: Physicochemical characterization of the Strychnos alkaloids by capillary zone electrophoresis. PubMed: Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay. PubMed: Neural representation of bitter taste in the nucleus of the solitary tract. PubMed: Spectrophotometric determination of urinary iodine by the Sandell-Kolthoff reaction subsequent to dry alkaline ashing. Results from the Czech Republic in the period 1994-2002. PubMed: [Concentration and determination of strychnine alkaloid in biological fluids]. PubMed: Cyclic water pentamers in triclinic crystals of brucinium L-glycerate. PubMed: New PVC nitrate-selective electrode: application to vegetables and mineral waters. PubMed: Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators. PubMed: Brucine and two solvates. PubMed: Direct determination of brucine by square wave voltammetry on 4-amino-2-mercaptopyrimidine self-assembled monolayer gold electrode. PubMed: Resolution of (+/-)-ibuprofen using (-)-brucine as a chiral selector by thin layer chromatography. PubMed: Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor. PubMed: Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by 1H nuclear magnetic resonance spectrometry and multivariate analysis techniques. PubMed: Transverse dephasing optimised NMR spectroscopy in solids: natural-abundance 13C correlation spectra. PubMed: Optimized and validated spectrophotometric methods for the determination of nicorandil in drug formulations and biological fluids. PubMed: Analysis of strychnine from detoxified Strychnos nux-vomica [corrected] seeds using liquid chromatography-electrospray mass spectrometry. PubMed: Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. PubMed: Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay. PubMed: Analysis of strychnine and brucine in postmortem specimens by RP-HPLC: a case report of fatal intoxication. PubMed: The indole alkaloids brucine, yohimbine, and hypaphorine are indole-3-acetic acid-specific competitors which do not alter auxin transport. PubMed: On-chip potential gradient detection with a portable capillary electrophoresis system. PubMed: Quantitative analysis of strychnine and Brucine in Strychnos nux-vomica using 1H-NMR. PubMed: [Pharmacokinetics of the alkaloids from the processed seeds of Strychnos nux-vomica in rats]. PubMed: Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica. PubMed: Highly sensitive reaction of nitrate with brucine and 3-methyl-2-benzothiazolinone hydrazone hydrochloride for the determination of nitrate in environmental samples. PubMed: [HPLC determination of strychnine and brucine in Semen Strychni and its processed products]. PubMed: Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M2 receptors. PubMed: Capillary electrophoresis with field-enhanced stacking for rapid and sensitive determination of strychnine and brucine. PubMed: Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice. PubMed: [Determination of brucine in seed dressing agents by high performance liquid chromatography]. PubMed: First synthesis of racemic saphenamycin and its enantiomers. investigation of biological activity. PubMed: [Increased level of nitric oxide stable metabolites in the blood of highlanders]. PubMed: Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. PubMed: Herbal medicine causing likely strychnine poisoning. PubMed: Atypical time course of clinical signs in a dog poisoned by strychnine. PubMed: Enantiopure spiro[3.3]heptane-2,6-dicarboxylic acid. PubMed: Asymmetric carbon-carbon coupling of phenols or anilines with aryllead triacetates. PubMed: Enzymatic and non-enzymatic reduction of brucine N-oxide by aldehyde oxidase and catalase. PubMed: [Influence of processing methods on alkaloid, toxicity and effect of Strychnos nux-vomica L]. PubMed: [Determation of strychnine and brucine in Strychnos by HPLC]. PubMed: A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines. PubMed: Interactions between allosteric modulators and 4-DAMP and other antagonists at muscarinic receptors: potential significance of the distance between the N and carboxyl C atoms in the molecules of antagonists. PubMed: Multiple allosteric sites on muscarinic receptors. PubMed: Nitric oxide and chronic HCV and HIV infections. PubMed: Non-enzymatic reduction of aliphatic tertiary amine N-oxides mediated by the haem moiety of cytochrome P450. PubMed: A new chiral selector based on trans-acenaphthen-1,2-dicarboxylic acid. PubMed: Separation and determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation by capillary zone electrophoresis. PubMed: Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors. PubMed: Effects of brucine, a plant alkaloid, on M(1) muscarinic receptors and alpha(1)-adrenoceptors in the rabbit vas deferens preparation. PubMed: Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. PubMed: Determination of the alkaloid content in different parts of some Mahonia plants by HPCE. PubMed: Direct enantiomeric resolution of some 2-arylpropionic acids using (-)-brucine-impregnated thin-layer chromatography. PubMed: Cytotoxicities of alkaloids from processed and unprocessed seeds of Strychnos nux-vomica. PubMed: Effect of brucine on mouse nonspecific immune responses. PubMed: Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies. PubMed: Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors. PubMed: Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors. PubMed: A unique tertiary amine N-oxide reduction system composed of quinone reductase and heme in rat liver preparations. PubMed: Quinone-dependent tertiary amine N-oxide reduction in rat blood. PubMed: The effects of brucine and alcuronium on the inhibition of [3H]acetylcholine release from rat striatum by muscarinic receptor agonists. PubMed: Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. PubMed: Membrane potential responses of paramecium caudatum to bitter substances: existence of multiple pathways for bitter responses PubMed: Behavioral specificity of the bitter taste gene Soa. PubMed: Nonenzymatic reduction of brucine N-oxide by the heme group of cytochrome P450. PubMed: Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. PubMed: [Chemical constituents of Strychnos nitida G. Don]. PubMed: Age-related changes of urinary nitrite/nitrate excretion in normal children. PubMed: Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes. PubMed: Spectrophotometric determination of urinary iodine by flow-injection analysis with on-line catalytic digestion. PubMed: SW.B6-Soa(b) nontaster congenic strains completed and a sucrose octaacetate congenic quartet tested with other bitters. PubMed: Brucine as a potent inducer of CYP2B3, the third member of the CYP2B subfamily P450 in rats. PubMed: Effects of chronic treatment with losartan on blood pressure, endothelin-like immunoreactivity and nitric oxide in normotensive rats. PubMed: Indirect measurement of brucine by adsorptive stripping voltammetry at mercury electrode. PubMed: Determination of strychnine and brucine by capillary zone electrophoresis. PubMed: On identifying a second molecular antagonistic mechanism operative at the glycine receptor. PubMed: Quinine-HCl-induced modification of receptor potentials for taste stimuli in frog taste cells. PubMed: [Influence of different processing methods of four alkaloid contents in Strychnos nux-vomica L]. PubMed: Genetics of bitter perception in mice. PubMed: Strychnine-binding proteins in intestinal cells: novel brucine binding site with binding affinities for alkaloids. PubMed: Novel and potent aldose reductase inhibitors: 4-benzyl- and 4-(benzothiazol-2-ylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-ac etic acid derivatives. PubMed: [Effect of processing on the alkaloids in Strychnos nux-vomica L]. PubMed: Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase. PubMed: A putative cytoprotective receptor in the kidney: relation to the neuronal strychnine-sensitive glycine receptor. PubMed: [Studies on the chemical constituents of alkaloids in seeds of Strychnos nux-vomica L]. PubMed: Metabolism of strychnine N-oxide and brucine N-oxide by human intestinal bacteria. PubMed: [Effect of processing on the extraction of alkaloids from Strychnos]. PubMed: [An attempt to investigate the effect of magnesium ion supplements on changes in levels of nitrates and nitrites in selected pickled vegetables]. PubMed: Comparison of binding at strychnine-sensitive (inhibitory glycine receptor) and strychnine-insensitive (N-methyl-D-aspartate receptor) glycine binding sites. PubMed: Strychnine-induced potassium current in CA1 pyramidal neurones of the rat hippocampus. PubMed: Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones. PubMed: Brucine lethality in mice. PubMed: [Effect of the fermentation process on levels of nitrates and nitrites in selected vegetables]. PubMed: [Simultaneous determination of brucine and strychnine in semen Strychni by dual wavelength spectrophotometry and studies on processing principles of semen Strychni]. PubMed: [Quantitative determination of strychnine and brucine in semen Strychni and its preparations by gas chromatography]. PubMed: Processing of nux vomica. II. Changes in alkaloid composition of the seeds of Strychnos nux-vomica on traditional drug-processing. PubMed: [Combinations of borotungstic acid with nitrogenous compounds]. PubMed: Photosynthetic control, "energy-dependent" quenching of chlorophyll fluorescence and photophosphorylation under influence of tertiary amines. PubMed: Glassy state of pharmaceuticals. IV. Studies on glassy pharmaceuticals by thermomechanical analysis. PubMed: [Studies on the relation of alkaloids in semen Strychni and its processing]. PubMed: A re-examination of the Na+-independent binding of [3H]beta-alanine to rat brain stem-spinal cord. PubMed: Thermodynamic evaluation of activated charcoal as a poison antidote by high-performance liquid chromatography. II: In vitro method for the evaluation of activated charcoal as a poison antidote. PubMed: Effect of inferior olive lesion on seizure threshold in the rat. PubMed: Protein ligand interactions. Indole alkaloids as inhibitors for lactate dehydrogenase. PubMed: A recombinagenic effect of strychnine in Salmonella typhimurium. PubMed: Glycine antagonists structurally related to 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol inhibit binding of [3H]strychnine to rat brain membranes. PubMed: Iontophoretic studies on rat hippocampus with some novel GABA antagonists. PubMed: Droplet counter-current chromatography of alkaloids. The influence of ph-gradients and ion-pair formation on the retention of alkaloids. PubMed: Tlc - spectrophotometric analysis of strychnine and brucine from the ayurvedic pills of nux vomica. PubMed: [Quality control of galenic preparations of nux vomica: proposal for a new method of extracting and assaying strychnine and brucine]. PubMed: Cardiac stimulation of brucine in cockroach Periplaneta americana, L. PubMed: First derivative spectrophotometric determination of strychnine and brucine in nux vomica liquid extract. PubMed: Toxic alkaloids and their interaction with microsomal cytochrome P-450 in vitro. PubMed: A new high performance liquid chromatography (HPLC) method for the quantitation of strychnine in urine and tissue extracts. PubMed: The adaptation of the frog tongue to various taste solutions: the effect on gustatory neural responses to bitter stimuli. PubMed: 13C-NMR experimental methods for determination of resonance multiplicities: Strychnos alkaloids. PubMed: Assignment of 13C-NMR spectra of strychnine and brucine. PubMed: An experimental model of hyper-irritability in the trigeminal skin field of the rat. PubMed: 13C-NMR spectra of strychnos alkaloids: brucine and strychnine. PubMed: Absolute configuration of (+)-5-(o-hydroxyphenyl)-5-phenylhydantoin, the major metabolite of 5,5-diphenylhydantoin in the dog. PubMed: Spectrophotometric determination of strychnine and brucine in liquid galenicals. PubMed: Potential carcinostatics. Synthesis and biological properties of d- and 1-beta,beta-difluoroaspartic acid and beta,beta-difluoroasparagine. PubMed: Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-k-fluorouracil into the R and S isomers and examination of the biological activities of the isomers. PubMed: Observations on the reaction between nitric acid and brucine. PubMed: The alkaloids of Strychnos dolichothyrsa. PubMed: A relatively simple differential screening test for GABA or glycine antagonists using rat electroretinography. PubMed: Mechanism of action of some bitter-tasting compounds on frog taste cells. PubMed: Formation of beta-methylmalate and its conversion to citramalate in Rhodospirillum rubrum. PubMed: Simultaneous assay for six alkaloids in opium, using high-performance liquid chromatography. PubMed: Colorimetric assay of strychnine and brucine in nux vomica. PubMed: GLC determination of strychnine and brucine in pharmaceutical preparations. PubMed: [In Process Citation]. PubMed: Tentative method of analysis for nitrate in atmospheric particulate matter (brucine method) 12306-02-72T. PubMed: Three acetylcholine receptors in Aplysia neurones. PubMed: [Colorimetric determination of strychnine and brucine in Semen Strychni and galenic preparations by chromatographic separation]. PubMed: [Colorimetric determination of strychnine and brucine after chromatographic resolution of mixtures of the substances]. PubMed: [Colorimetric method of determination of content of the total amount of strychnine and brucine in the seeds of strychnos nux vomica (Semen Strychni) and in galenic preparations]. PubMed: [Studies on the extraction of plant constituents. IV. Extraction of strychinine and brucine from strychni semen]. PubMed: [Strychnine and brucine determination in Strychnos Nux Vomica seeds]. PubMed: Determination of organic bases in non-aqueous solvents by catalytic thermometric titration. PubMed: Studies on strychnine derivatives and conversion into brucine. 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