butyl 4-aminobenzoate

benzoic acid, 4-amino-, butyl ester

CAS: 94-25-7 C11 H15 N O2 MW: 193.24595000

Identification

Namebutyl 4-aminobenzoate
IUPACbutyl 4-aminobenzoate
CAS Number94-25-7
EINECS202-317-1
FDA UNIIEFW857872Q
Molecular FormulaC11 H15 N O2
Molecular Weight193.24595000
MDL NumberMFCD00017112
Nikkaji NumberJ4.698A
Beilstein1211465
XlogP32.90 (est)

Regulatory

Physical Properties

Appearance yellw powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 58.00 °C. @ 760.00 mm Hg
Boiling Point 325.68 °C. @ 760.00 mm Hg (est)
Flash Point 364.00 °F. TCC ( 184.60 °C. ) (est)
logP (o/w) 2.870
Soluble in water, 167.6 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 67 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for butyl 4-aminobenzoate usage levels up tonot for fragrance use.
Recommendation for butyl 4-aminobenzoate flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

4- amino-benzoic acid butyl ester 4- aminobenzoic acid butyl ester p- aminobenzoic acid butyl ester 4- aminobenzoic acid n-butyl ester p- aminobenzoic acid, butyl ester benzoic acid, 4-amino-, butyl ester benzoic acid, p-amino-, butyl ester butamben butesin butoform 4-( butoxycarbonyl)aniline butyl p-aminobenzoate N- butyl p-aminobenzoate butyl PABA butyl-4-aminobenzoate N- butyl-p-aminobenzoate butylcaine planoform scuroform zyljectin PubMed: Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate. PubMed: The effect of oral topical anesthesia on the characteristics of voice. PubMed: Transdermal delivery of butamben using elastic and conventional liposomes. PubMed: Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben. PubMed: Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression. PubMed: New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics. PubMed: On the bioreactivity of triorganotin aminobenzoates. Investigation of trialkyl and triarylyltin(IV) esters of 3-amino and 4-aminobenzoic acids. PubMed: The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells. PubMed: The local anesthetic butamben inhibits and accelerates low-voltage activated T-type currents in small sensory neurons. PubMed: Structural characteristics and crystal polymorphism of three local anaesthetic bases crystal polymorphism of local anaesthetic drugs: part VII. PubMed: Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben. PubMed: The block of total and N-type calcium conductance in mouse sensory neurons by the local anesthetic n-butyl-p-aminobenzoate. PubMed: Analgesic synergy between topical morphine and butamben in mice. PubMed: Antifolate chemistry: synthesis of 4-[N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino]benzoic acid via a (propargyl)Co2(CO)6+ complex. PubMed: Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry. PubMed: Purification and characterization of PrbA, a new esterase from Enterobacter cloacae hydrolyzing the esters of 4-hydroxybenzoic acid (parabens). PubMed: Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain. PubMed: Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. PubMed: The antinociceptive and histologic effect of sciatic nerve blocks with 5% butamben suspension in rats. PubMed: Comparison of epidural butamben to celiac plexus neurolytic block for the treatment of the pain of pancreatic cancer. PubMed: Diffusion of n-butyl-p-aminobenzoate (BAB), lidocaine and bupivacaine through the human dura-arachnoid mater in vitro. PubMed: Orientations and locations of local anesthetics benzocaine and butamben in phospholipid membranes as studied by 2H NMR spectroscopy. PubMed: Identification of a yellow impurity in aged samples of aqueous butamben suspension: evidence for the oxidative degradation of poly(ethylene glycol). PubMed: Methemoglobinemia induced by topical anesthesia: a case report and review. PubMed: The long-term effect of epidural administration of butamben suspension on nerve injury-induced allodynia in rats. PubMed: Particle size determination of a flocculated suspension using a light-scattering particle size analyzer. PubMed: Nerve blocks with 5% butamben suspension for the treatment of chronic pain syndromes. PubMed: Partition coefficients (n-octanol/water) of N-butyl-p-aminobenzoate and other local anesthetics measured by reversed-phase high-performance liquid chromatography. PubMed: Epidural and intrathecal n-butyl-p-aminobenzoate solution in the rat. Comparison with bupivacaine. PubMed: The local anesthetic, n-butyl-p-aminobenzoate, reduces rat sensory neuron excitability by differential actions on fast and slow Na+ current components. PubMed: Characterization of site I on human serum albumin: concept about the structure of a drug binding site. PubMed: Analgesic efficacy of topical butamben picrate. PubMed: Capillary gas chromatographic method for the determination of n-butyl-p-aminobenzoate and lidocaine in plasma samples. PubMed: The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. PubMed: Formulation factors affecting release of drug from topical vehicles. II. Effect of solubility on in vitro delivery of a series of n-alkyl p-aminobenzoates. PubMed: Long-lasting epidural sensory blockade by n-butyl-p-aminobenzoate in the terminally ill intractable cancer pain patient. PubMed: Preliminary study to assay plasma amethocaine concentrations after topical application of a new local anaesthetic cream containing amethocaine. PubMed: A 'forgotten' topical anaesthetic sensitizer: butyl aminobenzoate. PubMed: Butyl-p-aminobenzoate. Preparation, characterization and quality control of a suspension injection for epidural analgesia. PubMed: Long-lasting epidural sensory blockade by n-butyl p-aminobenzoate in the dog: neurotoxic or local anesthetic effect? PubMed: Effect of epidural and subarachnoid injections of a 10% butamben suspension. PubMed: Flocculation of suspensions containing nonionic surfactants by sorbitol. PubMed: Evaluation of anesthetic agents on human mucous membrane: an illustration of experimental protocol using computers. PubMed: [Clinical evaluation of new toothache drug "LTA"]. PubMed: Topical anesthetics: use and misuse. PubMed: [Clinical investigation of the action of lidocaine, procaine and butanylcaine]. PubMed: Methemoglobinemia induced by local anesthetics. PubMed: Controlled drug permeation. II. Comparative permeability and stability of butamben and benzocaine. PubMed: Controlled drug permeation I: controlled release of butamben through silicone membrane by complexation. PubMed: Specificity of eczematous hypersensitivity to p-aminobenzoic acid butyl ester (butesin).