carbamazepine

5H-dibenzo[b,f]azépine-5-carboxamide

CAS: 298-46-4 C15 H12 N2 O MW: 236.27384000

Identification

Namecarbamazepine
IUPACbenzo[b][1]benzazepine-11-carboxamide
CAS Number298-46-4
EINECS206-062-7
FDA UNII33CM23913M
Molecular FormulaC15 H12 N2 O
Molecular Weight236.27384000
MDL NumberMFCD00005073
Nikkaji NumberJ8.590A
Beilstein1246090
XlogP32.50 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 190.20 °C. @ 760.00 mm Hg
Boiling Point 410.98 °C. @ 760.00 mm Hg (est)
Vapor Pressure 1.840000 mmHg @ 25.00 °C. (est)
Flash Point 396.00 °F. TCC ( 202.40 °C. ) (est)
logP (o/w) 2.450
Soluble in water, 17.66 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-child TDLo 19 mg/kg/4W-I
Dermal Toxicitysubcutaneous-mouse LD50 > 1000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for carbamazepine usage levels up tonot for fragrance use.
Recommendation for carbamazepine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzo[b][1]benzazepine-11-carboxamide calepsin carbamazepen carbamazepin carbamazepinum carbamezepine 5- carbamoyl-5H-dibenz(b,f)azepine 5- carbamoyl-5H-dibenz[b,f]azepine 5- carbamoyl-5H-dibenzo(b,f)azepine 5- carbamoyldibenzo(b,f)azepine 5- carbamyl-5H-dibenzo(b,f)azepine 5- carbamyldibenzo(b,f)azepine carbamzepine carbatrol carbazepine carbelan 5H- dibenz(b,f)azepine-5-carboxamide 5H- dibenz[b,f]azepine-5-carboxamide 5H- dibenz[b,f]azepine-5-carboximidic acid 5H- dibenzb,fazepine-5-carboxamide 5H- dibenzo[b,f]azépine-5-carboxamide equetro neurotol novo-carbamaz sirtal stazepin tegretal tegretol Cr 2-aza tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide PubMed: Dystonia. PubMed: Tinnitus. PubMed: Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream. PubMed: Trigeminal neuralgia. PubMed: Lactation studies of anticonvulsants: A quality review. PubMed: Potential of newly isolated wild Streptomyces strains as agents for the biodegradation of a recalcitrant pharmaceutical, carbamazepine. PubMed: Modeling uptake of selected pharmaceuticals and personal care products into food crops from biosolids-amended soil. PubMed: Presence of the pharmaceutical drug carbamazepine in coastal systems: Effects on bivalves. PubMed: Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice. PubMed: The effects of the pharmaceutical carbamazepine on life history characteristics of flat-headed mayflies (Heptageniidae) and aquatic resource interactions. PubMed: The effects of the psychiatric drug carbamazepine on freshwater invertebrate communities and ecosystem dynamics. PubMed: [Pharmacogenetic research in the association between human leukocyte antigen and adverse drug reactions]. PubMed: Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks. PubMed: Crushed tablets: does the administration of food vehicles and thickened fluids to aid medication swallowing alter drug release? PubMed: Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals. PubMed: Ancestry-based pharmacogenomics, adverse reactions and carbamazepine: is the FDA warning correct? PubMed: [Future direction of pharmacogenomics: identification of genes associated with risk of adverse drug reactions using genome-wide association study]. PubMed: Update on once-daily zonisamide monotherapy in partial seizures. PubMed: Fate and uptake of pharmaceuticals in soil-plant systems. PubMed: The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography–tandem mass spectrometry. PubMed: Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model. PubMed: Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater. PubMed: Predictive validity of a MK-801-induced cognitive impairment model in mice: implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically. PubMed: Clinically significant drug interactions with atypical antipsychotics. PubMed: Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers. PubMed: The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography-tandem mass spectrometry. PubMed: Fingerprinting groundwater pollution in catchments with contrasting contaminant sources using microorganic compounds. PubMed: Is Atyaephyra desmarestii a useful candidate for lethal and sub-lethal toxicity tests on pharmaceutical compounds? PubMed: Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus. PubMed: Interaction of carbamazepine with herbs, dietary supplements, and food: a systematic review. PubMed: Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. PubMed: A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. PubMed: Adsorption of carbamazepine by carbon nanotubes: effects of DOM introduction and competition with phenanthrene and bisphenol A. PubMed: Glutamic acid decarboxylase gene disruption reveals signalling pathway(s) governing complex morphogenic and metabolic events in Trichoderma atroviride. PubMed: Relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. PubMed: Foliar sorption of emerging and priority contaminants under controlled conditions. PubMed: Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence. PubMed: Anti-solvent co-crystallization of carbamazepine and saccharin. PubMed: Evaluation of unlicensed and off-label antiepileptic drugs prescribed to children: Brazilian Regulatory Agency versus FDA. PubMed: Grapefruit and drug interactions. PubMed: A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for cycloserine in 50μL of human plasma: Its pharmacokinetic application. PubMed: Boceprevir: a recently approved protease inhibitor for hepatitis C virus infection. PubMed: Carbamazepine-induced hypersensitivity syndrome in chronic schizophrenia. PubMed: Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain). PubMed: Plant uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed wastewater. PubMed: Occurrence of micro-organic pollutants on phosphorus recovery from urine. PubMed: A pilot survey of 39 Victorian WWTP effluents using a high speed luminescent umu test in conjunction with a novel GC-MS-database technique for automatic identification of micropollutants. PubMed: Fatal serotonin syndrome precipitated by oxcarbazepine in a patient using an selective serotonin reuptake inhibitor. PubMed: Simultaneous determination of sitagliptin and simvastatin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. PubMed: Efficacy of antimanic treatments in mixed states. PubMed: Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review. PubMed: HLA-B*1502 allele is associated with a cross-reactivity pattern of cutaneous adverse reactions to antiepileptic drugs. PubMed: Epilepsy (generalised). PubMed: Tinnitus. PubMed: Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field. PubMed: Effect of the timing of food intake on the absorption and bioavailability of carbamazepine immediate-release tablets in beagle dogs. PubMed: Reflex seizures in Rett syndrome. PubMed: Review of risk from potential emerging contaminants in UK groundwater. PubMed: Dementia. PubMed: Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study. PubMed: A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models. PubMed: Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats. PubMed: Transformation of the recalcitrant pharmaceutical compound carbamazepine by Pleurotus ostreatus: role of cytochrome P450 monooxygenase and manganese peroxidase. PubMed: Morphine sensitization as a model of mania: comparative study of the effects of repeated lithium or carbamazepine administration. PubMed: Physico-mechanical and stability evaluation of carbamazepine cocrystal with nicotinamide. PubMed: Epilepsy (partial). PubMed: Interactions of carbamazepine in soil: effects of dissolved organic matter. PubMed: Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. PubMed: Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. PubMed: Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs. PubMed: Physicochemical and mechanical properties of carbamazepine cocrystals with saccharin. PubMed: Utility of physiologically based absorption modeling in implementing Quality by Design in drug development. PubMed: Levetiracetam Extended Release as Adjuvant Therapy for the Control of Partial-onset Seizures. PubMed: Uptake of carbamazepine by cucumber plants--a case study related to irrigation with reclaimed wastewater. PubMed: Do antiepileptic drugs increase the risk of suicidality in adult patients with epilepsy?: a critically appraised topic. PubMed: Carbamazepine alone and in combination with doxycycline attenuates isoproterenol-induced cardiac hypertrophy. PubMed: Pharmacogenetics of toxic epidermal necrolysis. PubMed: Population-based severity, onset and type of drug-drug interactions in prescriptions. PubMed: Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma. PubMed: Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. PubMed: [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. PubMed: Human health risk assessment of pharmaceuticals in water: an uncertainty analysis for meprobamate, carbamazepine, and phenytoin. PubMed: Dementia. PubMed: Epilepsy (partial). PubMed: Epilepsy (generalised). PubMed: A novel HPLC method for quantification of 10 antiepileptic drugs or metabolites in serum/plasma using a monolithic column. PubMed: Prescriber compliance with black box warnings in older adult patients. PubMed: Occurrence of pharmaceutically active compounds in surface waters of the Henares-Jarama-Tajo River system (Madrid, Spain) and a potential risk characterization. PubMed: Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder. PubMed: Pharmacologic treatment of impulsive aggression with antiepileptic drugs. PubMed: Effect of soybean administration on the pharmacokinetics of carbamazepine and omeprazole in rats. PubMed: Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field. PubMed: Epilepsy. PubMed: Trigeminal neuralgia. PubMed: Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field. PubMed: Teratogenesis associated with antibipolar agents. PubMed: [Pharmacokinetic problems in clinical practice: role of drug transporters]. PubMed: Don't live in a town where there are no doctors: toxic epidermal necrolysis initially misdiagnosed as oral thrush. PubMed: Tinnitus. PubMed: FDA: Epilepsy drugs may carry skin risks for Asians. PubMed: Medication administration through enteral feeding tubes. PubMed: Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. PubMed: For Asians only? The perils of ancestry-based drug prescribing. PubMed: Update on pharmacotherapy guidelines for the treatment of neuropathic pain. PubMed: Sorption and mobility of pharmaceutical compounds in soil irrigated with reclaimed wastewater. PubMed: Generic substitution in the treatment of epilepsy: case evidence of breakthrough seizures. PubMed: Genotoxic assessment of oxcarbazepine and carbamazepine in drosophila wing spot test. PubMed: Generic antiepileptic drugs. PubMed: Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. PubMed: Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids. PubMed: Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field. PubMed: Mode of action of mood stabilizers: is the arachidonic acid cascade a common target? PubMed: Monotherapy versus combined treatment with second-generation antipsychotics in bipolar disorder. PubMed: Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta. PubMed: Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols. PubMed: Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review. PubMed: Effects of sodium valproate and carbamazepine on food competition aggression in pigeons. PubMed: Overview of the clinical pharmacokinetics of oxcarbazepine. PubMed: Tinnitus. PubMed: Post-traumatic stress disorder. PubMed: Bipolar disorder. PubMed: Historical review of carbamazepine for the treatment of bipolar disorder. PubMed: The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials. PubMed: Extended-release carbamazepine for acute bipolar mania: a review. PubMed: Nonepileptic uses of antiepileptic drugs in children and adolescents. PubMed: Active control trials for epilepsy: avoiding bias in head-to-head trials. PubMed: Life-history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine. PubMed: Carbamazepine extended-release capsules in bipolar disorder. PubMed: Oxcarbazepine in the treatment of child psychiatric disorders: a retrospective chart review. PubMed: Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby. PubMed: Transient inhibition of cyp3a in rats by star fruit juice. PubMed: Pharmaceutical data do not elude researchers. PubMed: Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder. PubMed: Contribution of effluents from hospitals and private households to the total loads of diclofenac and carbamazepine in municipal sewage effluents--modeling versus measurements. PubMed: In vitro assessment of modes of toxic action of pharmaceuticals in aquatic life. PubMed: Pharmaceutical data elude researchers. PubMed: Neural tube defects: pathogenesis and folate metabolism. PubMed: Human pharmaceuticals, hormones, and personal care product ingredients in runoff from agricultural fields irrigated with treated wastewater. PubMed: Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. PubMed: Influence of high fat diet (butter) on pharmacokinetics of phenytoin and carbamazepine. PubMed: Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. PubMed: Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain. PubMed: Determination of polar drug residues in sewage and surface water applying liquid chromatography-tandem mass spectrometry. PubMed: Clinical experience with aripiprazole treatment in ten elderly patients with schizophrenia or schizoaffective disorder: retrospective case studies. PubMed: Choice of rotation speed (rpm) for bio-relevant drug dissolution testing using a crescent-shaped spindle. PubMed: Pharmacokinetic interactions of topiramate. PubMed: Clinical pharmacokinetics of levetiracetam. PubMed: Newer anticonvulsants in the treatment of bipolar disorder. PubMed: Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. PubMed: Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. PubMed: Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. PubMed: Chronic prenatal exposure to carbamazepine and behavior effects on mice offspring. PubMed: Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs). PubMed: The use of folic acid for the prevention of neural tube defects and other congenital anomalies. PubMed: Effect of concomitantly administered honey on the pharmacokinetics of carbamazepine in healthy volunteers. PubMed: Pharmacokinetics and metabolism of topiramate. PubMed: The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? PubMed: Applications of a new device (spindle) for improved characterization of drug release (dissolution) of pharmaceutical products. PubMed: The bioequivalence and therapeutic efficacy of generic versus brand-name psychoactive drugs. PubMed: Dietary carbamazepine administration decreases liver pyruvate carboxylase activity and biotinylation by decreasing protein and mRNA expression in rats. PubMed: New antiepileptic drugs. PubMed: Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. PubMed: Oxcarbazepine final market image tablet formulation bioequivalence study after single administration and at steady state in healthy subjects. PubMed: Effect of honey on carbamazepine kinetics in rabbits. PubMed: Side effect profiles and behavioral consequences of antiepileptic medications. PubMed: The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine. PubMed: Differential effects of carbamazepine on negatively versus positively reinforced responding. PubMed: Neurologic drug-psychotropic drug update. PubMed: Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. PubMed: Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. PubMed: Three new drugs for epilepsy: levetiracetam, oxcarbazepine, and zonisamide. PubMed: Epilepsy in Pregnant Women. PubMed: Clinical experience with topiramate dosing and serum levels in children 12 years or under with epilepsy. PubMed: [Ciguatera: clinical relevance of a marine neurotoxin]. PubMed: Delavirdine: clinical pharmacokinetics and drug interactions. PubMed: Effect of grapefruit intake on carbamazepine bioavailability: a case report. PubMed: The importance of folic acid. PubMed: The influence of food on the bioavailability of a twice-daily controlled release carbamazepine formulation. PubMed: [Excessive weight loss caused by dysphagia in superior laryngeal nerve neuralgia--a case report]. PubMed: Clinical pharmacokinetics of mirtazapine. PubMed: Carbamazepine suppresses methamphetamine-induced Fos expression in a regionally specific manner in the rat brain. Possible neural substrates responsible for antimanic effects of mood stabilizers. PubMed: Oxcarbazepine approved for partial seizures. PubMed: The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures. PubMed: Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam. PubMed: Isoniazid drug and food interactions. PubMed: A multiple-dose safety and bioequivalence study of a narrow therapeutic index drug: a case for carbamazepine. PubMed: Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. PubMed: Pharmacokinetic evaluation of twice-daily extended-release carbamazepine (CBZ) and four-times-daily immediate-release CBZ in patients with epilepsy. PubMed: A limited sampling method for the estimation of AUC and Cmax of carbamazepine and carbamazepine epoxide following a single and multiple dose of a sustained-release product. PubMed: Newer antiepileptic drugs: gabapentin, lamotrigine, felbamate, topiramate and fosphenytoin. PubMed: Lithium plus valproate as maintenance polypharmacy for patients with bipolar I disorder: a review. PubMed: Influence of food on the bioavailability of a carbamazepine slow-release formulation. PubMed: Lithium, but not carbamazepine, potentiates hyperactivity induced by intra-accumbens cholera toxin. PubMed: Clinical pharmacokinetics of nefazodone. PubMed: Recent advances in the pharmacotherapy of epilepsy. PubMed: A limited sampling method for the estimation of flunarizine area under the curve (AUC) and maximum plasma concentration (Cmax). PubMed: Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. PubMed: Monotherapy trials of new antiepileptic drugs. PubMed: In vitro dissolution profile comparison and IVIVR. Carbamazepine case. PubMed: The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement. PubMed: In vitro embryotoxicity of carbamazepine and carbamazepine-10, 11-epoxide. PubMed: Effects of anticonvulsants in a novel operant learning paradigm in rats: comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents. PubMed: Use of lithium, carbamazepine, and valproic acid in a state-operated psychiatric hospital. PubMed: Overview of the pharmacokinetics of fluvoxamine. PubMed: Interactions of warfarin with drugs and food. PubMed: The influence of food on the disposition of the antiepileptic oxcarbazepine and its major metabolites in healthy volunteers. PubMed: [Acute catatonia and neuroleptic malignant syndrome. A case of infantile psychosis]. PubMed: Clinical pharmacology and pharmacokinetics of oxcarbazepine. PubMed: Oxcarbazepine: clinical development program. PubMed: Pharmacokinetic optimisation of oral antifungal therapy. PubMed: Effects of humidity and temperature on in vitro dissolution of carbamazepine tablets. PubMed: Norplant: a welcome new contraceptive. PubMed: Advances in the pharmacotherapy of epilepsy. PubMed: The pharmacologic treatment of conduct disorders and rage outbursts. PubMed: Carbamazepine produces nonspecific effects on cocaine self-administration in rats. PubMed: Carbamazepine and folic acid in trigeminal neuralgia patients. PubMed: Clinical toleration and safety of azithromycin. PubMed: Weight gain, increased appetite, and excessive food intake induced by carbamazepine. PubMed: Spina bifida in infants of women treated with carbamazepine during pregnancy. PubMed: Generic substitutions for antiepileptic drugs. PubMed: Effects of carbamazepine on self-administration of intravenously delivered cocaine in rats. PubMed: From the Food and Drug Administration. PubMed: In vivo determination of valproate binding constants during sole and multi-drug therapy. PubMed: Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948. PubMed: In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants. PubMed: Liquid chromatographic determination of carbamazepine in tablets. PubMed: Persistent upregulation of brain adenosine receptors in response to chronic carbamazepine treatment. PubMed: Isoniazid interactions. PubMed: Influence of food on the bioavailability of drugs. PubMed: Drugs 5 years later: carbamazepine. PubMed: A case of periodic somnolence whose sleep was induced by glucose.