carbendazim
carbamic acid, N-1H-benzimidazol-2-yl-, methyl ester
Identification
| Name | carbendazim |
| IUPAC | methyl N-(1H-benzimidazol-2-yl)carbamate |
| CAS Number | 10605-21-7 |
| EINECS | 234-232-0 |
| FDA UNII | H75J14AA89 |
| Molecular Formula | C9 H9 N3 O2 |
| Molecular Weight | 191.19013000 |
| MDL Number | MFCD00055390 |
| Nikkaji Number | J3.120H |
| Beilstein | 649044 |
| XlogP3 | 1.50 (est) |
Regulatory
Physical Properties
| Appearance | light gray or beige powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 300.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 7.500000 mmHg @ 20.00 °C. (est) |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | 1.520 |
| Soluble in | water, 29 mg/L @ 24C (exp) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-chicken LD50 1800 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 8500 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for carbendazim usage levels up to | not for fragrance use. |
| Recommendation for carbendazim flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
agrizim
antibac MF
battal
bavistan
bavistin
bavistin 3460
BCM (fungicide)
bengard
1H-
benzimidazol-2-ylcarbamic acid methyl ester
1H-
benzimidazol-2-ylcarbamic acid, methyl ester
benzimidazole carbamate de methyle
benzimidazole-2-carbamic acid, methyl ester
1H-
benzimidazole-2-carbamic acid, methyl ester
2-
benzimidazolecarbamic acid, methyl ester
bercema-bitosen
bitosen
BMK (fungicide)
carbamic acid, 1H-benzimidazol-2-yl-, methyl ester
carbamic acid, N-1H-benzimidazol-2-yl-, methyl ester
carben VL
carbendazime
carbendazol
carbendazole
carbendazym
2-(
carbomethoxyamino)benzimidazole
custos
delsene
derosal
equitdazin
falicarben
funaben
funaben 3
funaben 50
fungisol
garbenda
jkatein
karben
kemdazin
kolfugo
kolfugo 25 FW
2-
MBC
mecarzole
medamine
2-(
methoxy-carbonylamino)-benzimidazol
2-(
methoxycarbamoyl)benzimidazole
2-(
methoxycarbonylamino)-benzimidazole
methyl 1H-benzimidazol-2-ylcarbamate (9CI)
methyl 1H-benzimidazole-2-carbamate
methyl 2-benzimidazolecarbamate
methyl benzimidazol-2-ylcarbamate
methyl benzimidazolylcarbamate
methyl N-(1H-benzimidazol-2-yl)carbamate
methyl N-2-benzimidazolecarbamate
myco
pillarstin
preparation G 665
preventol BCM
stempor
supercarb
thicoper
triticol
PubMed:
Development and verification for analysis of pesticides in eggs and egg products using QuEChERS and LC-MS/MS.
PubMed:
[Laser Raman spectrum analysis of carbendazim pesticide].
PubMed:
Sensitive determination of carbendazim in orange juice by electrode modified with hybrid material.
PubMed:
Fungicide Sensitivity and Characterization of Cobweb Disease on a Pleurotus eryngii Mushroom Crop Caused by Cladobotryum mycophilum.
PubMed:
Design, synthesis, antifungal, and antioxidant activities of (E)-6-((2-phenylhydrazono)methyl)quinoxaline derivatives.
PubMed:
Kinetics of degradation of carbendazim by B. subtilis strains: possibility of in situ detoxification.
PubMed:
Small changes result in large differences: discovery of (-)-incrustoporin derivatives as novel antiviral and antifungal agents.
PubMed:
Genetic relationships, carbendazim sensitivity and mycotoxin production of the Fusarium graminearum populations from maize, wheat and rice in eastern China.
PubMed:
Pesticide monitoring in the basin of Llobregat River (Catalonia, Spain) and comparison with historical data.
PubMed:
Potential involvement of chemicals in liver cancer progression: an alternative toxicological approach combining biomarkers and innovative technologies.
PubMed:
Wightianines A-E, dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana, and their antifungal and insecticidal activities.
PubMed:
Antifungal activity of compounds extracted from Cortex Pseudolaricis against Colletotrichum gloeosporioides.
PubMed:
Pesticide residues in fruits and vegetables from the Aegean region, Turkey.
PubMed:
Synthesis and Antifungal Activity of Nicotinamide Derivatives as Succinate Dehydrogenase Inhibitors.
PubMed:
Secondary metabolites from the endophytic Botryosphaeria dothidea of Melia azedarach and their antifungal, antibacterial, antioxidant, and cytotoxic activities.
PubMed:
Pesticide residue analysis in parsley, lettuce and spinach by LC-MS/MS.
PubMed:
An integrated approach for the reduction of aflatoxin contamination in chilli (Capsicum annuum L.).
PubMed:
Determination of pesticide residue transfer rates (percent) from dried tea leaves to brewed tea.
PubMed:
Ultra-high performance liquid chromatography/ electrospray ionization-tandem mass spectrometry determination of 151 pesticides in soybeans and pulses.
PubMed:
Occurrence and removal efficiency of pesticides in sewage treatment plants of four Mediterranean River Basins.
PubMed:
Influence of different planting seasons of six leaf vegetables on residues of five pesticides.
PubMed:
Synthesis and biological evaluation of benzofuroxan derivatives as fungicides against phytopathogenic fungi.
PubMed:
Comparisons of metabolic and physiological changes in rats following short term oral dosing with pesticides commonly found in food.
PubMed:
Molecular characterization, fitness and mycotoxin production of benzimidazole-resistant isolates of Penicillium expansum.
PubMed:
Accumulation and half-lives of 13 pesticides in muscle tissue of freshwater fishes through food exposure.
PubMed:
Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
PubMed:
The inhibin B (InhB) response to the testicular toxicants mono-2-ethylhexyl phthalate (MEHP), 1,3 dinitrobenzene (DNB), or carbendazim (CBZ) following short-term repeat dosing in the male rat.
PubMed:
Capillary electrophoresis coupled to mass spectrometry for the determination of anthelmintic benzimidazoles in eggs using a QuEChERS with preconcentration as sample treatment.
PubMed:
Simple multiresidue extraction method for the determination of fungicides and plant growth regulator in bean sprouts using low temperature partitioning and tandem mass spectrometry.
PubMed:
Investigation of pesticide residues in vegetables and fruits grown in various regions of Hatay, Turkey.
PubMed:
[Benzimidazole and its derivatives--from fungicides to designer drugs. A new occupational and environmental hazards].
PubMed:
Monitoring and risk assessment of pesticide residues in yuza fruits (Citrus junos Sieb. ex Tanaka) and yuza tea samples produced in Korea.
PubMed:
Pesticide pressure and fish farming in barrage pond in Northeastern France. Part II: residues of 13 pesticides in water, sediments, edible fish and their relationships.
PubMed:
Determination of fungicide residues in baby food by liquid chromatography-ion trap tandem mass spectrometry.
PubMed:
Organic micropollutants in rivers downstream of the megacity Beijing: sources and mass fluxes in a large-scale wastewater irrigation system.
PubMed:
Effect of home processing on the distribution and reduction of pesticide residues in apples.
PubMed:
Protocol for an electrospray ionization tandem mass spectral product ion library: development and application for identification of 240 pesticides in foods.
PubMed:
[Determination of thiophanate-methyl and carbendazim in cucumber and soil by QuEChERS-high performance liquid chromatography-triple quadrupole tandem mass spectrometry].
PubMed:
Total diet study on pesticide residues in France: levels in food as consumed and chronic dietary risk to consumers.
PubMed:
Determination of pesticide residues in wine by membrane-assisted solvent extraction and high-performance liquid chromatography-tandem mass spectrometry.
PubMed:
Occurrence and distribution study of residues from pesticides applied under controlled conditions in the field during rice processing.
PubMed:
Effect of household and industrial processing on the levels of pesticide residues and degradation products in melons.
PubMed:
Pesticide pressure and fish farming in barrage pond in northeastern France. Part III: how management can affect pesticide profiles in edible fish?
PubMed:
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
PubMed:
[Rapid determination of 6 pesticide residues in tomato paste by ultra performance liquid chromatography-tandem mass spectrometry].
PubMed:
Role of fungicides, application of nozzle types, and the resistance level of wheat varieties in the control of Fusarium head blight and deoxynivalenol.
PubMed:
Carbendazim combined with imazalil or cypermethrin potentiate DNA damage in hepatocytes of mice.
PubMed:
Determination of sixteen pesticides in peppers using high-performance liquid chromatography/mass spectrometry.
PubMed:
Determination of carbendazim, thiophanate, thiophanate-methyl and benomyl residues in agricultural products by liquid chromatography-tandem mass spectrometry.
PubMed:
Dissipation and distribution behavior of azoxystrobin, carbendazim, and difenoconazole in pomegranate fruits.
PubMed:
Cumulative risk assessment of chemical exposures in urban environments.
PubMed:
Physico-chemical, respiratory and fungicide residue changes in wax coated mandarin fruit stored at chilling temperature with intermittent warming.
PubMed:
Effect of anilinopyrimidine resistance on aflatoxin production and fitness parameters in Aspergillus parasiticus Speare.
PubMed:
Reducing the impact of pesticides on biological control in Australian vineyards: pesticide mortality and fecundity effects on an indicator species, the predatory mite Euseius victoriensis (Acari: Phytoseiidae).
PubMed:
Realistic approach of pesticide residues and French consumer exposure within fruit & vegetable intake.
PubMed:
A selective spectrofluorimetric method for carbendazim determination in oranges involving inclusion-complex formation with cucurbit[7]uril.
PubMed:
Dissipation study of thiophanate methyl residue in/on grapes (Vitis vinifera L.) in India.
PubMed:
Quantification, confirmation and screening capability of UHPLC coupled to triple quadrupole and hybrid quadrupole time-of-flight mass spectrometry in pesticide residue analysis.
PubMed:
Simultaneous analysis of thiabendazole, carbendazim and 2-aminobenzimidazole in concentrated fruit juices by liquid chromatography after a single mix-mode solid-phase extraction cleanup.
PubMed:
Hollow fiber-liquid-phase microextraction of fungicides from orange juices.
PubMed:
Determination of pesticide residues in integrated pest management and nonintegrated pest management samples of apple (Malus pumila Mill.).
PubMed:
Mutations in a beta-tubulin confer resistance of Gibberella zeae to benzimidazole fungicides.
PubMed:
[Determination of carbendazim residue in orange and soil using high performance liquid chromatography].
PubMed:
Efficacy of Lippia alba (Mill.) N.E. Brown essential oil and its monoterpene aldehyde constituents against fungi isolated from some edible legume seeds and aflatoxin B1 production.
PubMed:
Brassinosteroids promote metabolism of pesticides in cucumber.
PubMed:
Bayesian modeling of measurement errors and pesticide concentration in dietary risk assessments.
PubMed:
Determination of pesticide residues in fruit-based soft drinks.
PubMed:
Predictive assessment of ochratoxin A accumulation in grape juice based-medium by Aspergillus carbonarius using neural networks.
PubMed:
Detection of carbendazim by surface-enhanced Raman scattering using cyclodextrin inclusion complexes on gold nanorods.
PubMed:
[Determination of benomyl, carbendazim and thiabendazole in apple juice concentrate using solid-phase extraction coupled with ion exchange chromatography].
PubMed:
Quantification of Fusarium graminearum in harvested grain by real-time polymerase chain reaction to assess efficacies of fungicides on fusarium head blight, deoxynivalenol contamination, and yield of winter wheat.
PubMed:
Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics.
PubMed:
Impact of postharvest disease control methods and cold storage on volatiles, color development and fruit quality in ripe 'kensington pride' mangoes.
PubMed:
Spectrofluorimetric determination of benzoimidazolic pesticides: effect of p-sulfonatocalix[6]arene and cyclodextrins.
PubMed:
Atmospheric pressure glow discharge desorption mass spectrometry for rapid screening of pesticides in food.
PubMed:
Design, synthesis, and fungicidal activity of macrolactones and macrolactams with a sulfonamide side chain.
PubMed:
Multiresidue method for fast determination of pesticides in fruit juices by ultra performance liquid chromatography coupled to tandem mass spectrometry.
PubMed:
Assessing the risk to U.K. children from carbendazim residues in apple products.
PubMed:
Determination of pesticide residues in IPM and non-IPM samples of mango (Mangifera indica).
PubMed:
Multi-residue analysis of traces of pesticides and antibiotics in honey by HPLC-MS-MS.
PubMed:
A sensitive determination method for carbendazim and thiabendazole in apples by solid-phase microextraction-high performance liquid chromatography with fluorescence detection.
PubMed:
[Study on usage of pesticides in various countries].
PubMed:
Determination of postharvest fungicides in fruit juices by solid-phase extraction followed by liquid chromatography electrospray time-of-flight mass spectrometry.
PubMed:
Multiple pesticide analysis in wine by MEKC combined with solid-phase microextraction and sample stacking.
PubMed:
Effect of carbendazim and physicochemical factors on the growth and ochratoxin A production of Aspergillus carbonarius isolated from grapes.
PubMed:
Analysis of pesticide multi-residues in leafy vegetables by ultrasonic solvent extraction and liquid chromatography-tandem mass spectrometry.
PubMed:
Analyses of pesticide residues in fruit-based baby food by liquid chromatography/electrospray ionization time-of-flight mass spectrometry.
PubMed:
MEKC combined with SPE and sample stacking for multiple analysis of pesticides in water samples at the ng/L level.
PubMed:
Comprehensive multi-residue method for the target analysis of pesticides in crops using liquid chromatography-tandem mass spectrometry.
PubMed:
On-line preconcentration strategies for analyzing pesticides in fruits and vegetables by micellar electrokinetic chromatography.
PubMed:
Determination of carbendazim residues in the eggs, liver and pectoral muscle of Japanese quail (Coturnix coturnix japonica).
PubMed:
Determination of pesticides in soy-based infant formula using liquid chromatography with electrospray ionization tandem mass spectrometry.
PubMed:
[Determination of carbendazim and thiabendazole in tomatoes by solid-phase microextraction coupled with high performance liquid chromatography and fluorescence detection].
PubMed:
Effects of the benzoxazolinone BOA, selected degradation products and structure related pesticides on soil organisms.
PubMed:
Determination of carbendazim residues in fruit juices by liquid chromatography-tandem mass spectrometry.
PubMed:
Screening and evaluation of fruit samples for four pesticide residues.
PubMed:
Investigation into the validity of extrapolation in setting maximum residue levels for pesticides in crops of similar morphology.
PubMed:
Fate of pesticides during the winemaking process in relation to malolactic fermentation.
PubMed:
Determination of pesticides in apple-based infant foods using liquid chromatography electrospray ionization tandem mass spectrometry.
PubMed:
Modeling the dietary pesticide exposures of young children.
PubMed:
Application of micellar electrokinetic capillary chromatography to the analysis of uncharged pesticides of environmental impact.
PubMed:
Repeated dose 28-day oral toxicity study in Wistar rats with a mixture of five pesticides often found as residues in food: alphacypermethrin, bromopropylate, carbendazim, chlorpyrifos and mancozeb.
PubMed:
Ring-testing and field-validation of a terrestrial model ecosystem (TME)--an instrument for testing potentially harmful substances: effects of carbendazim on nematodes.
PubMed:
Assessing N,N'-Dibutylurea (DBU) formation in soils after application of n-butylisocyanate and benlate fungicides.
PubMed:
Microwave-assisted extraction for the simultaneous determination of thiamethoxam, imidacloprid, and carbendazim residues in fresh and cooked vegetable samples.
PubMed:
Carbendazim and metalaxyl residues in post-harvest treated apples.
PubMed:
Occurrence of pesticide residues in mushrooms in Northern Ireland, July 1997-January 1999.
PubMed:
Cynodontin: a fungal metabolite with antifungal properties.
PubMed:
Modeling of single-step and multistep adsorption isotherms of organic pesticides on soil.
PubMed:
Subcritical water extraction to evaluate desorption behavior of organic pesticides in soil.
PubMed:
Is the application of carbendazim harmful to healthy plants? Evidence of weak phytotoxicity in tobacco.
PubMed:
Complexation of several benzimidazole-type fungicides with alpha- and beta-cyclodextrins.
PubMed:
Focused microwave assistance for extracting some pesticide residues from strawberries into water before their determination by SPME/HPLC/DAD.
PubMed:
Pesticide residues in oranges from Valencia (Spain).
PubMed:
Direct action of the biocide carbendazim on phenolic metabolism in tobacco plants.
PubMed:
An LC/MS/MS method for improved quantitation of the bound residues in the tissues of animals orally dosed with [(14)C]Benomyl.
PubMed:
Determination of imidacloprid and benzimidazole residues in fruits and vegetables by liquid chromatography-mass spectrometry after ethyl acetate multiresidue extraction.
PubMed:
Effect of temperature and humidity on the formation of dibutylurea in benlate fungicide.
PubMed:
Kuwait's total diet study: dietary intake of organochlorine, carbamate, benzimidazole and phenylurea pesticide residues.
PubMed:
Automated method for cleanup and determination of benomyl and thiabendazole in table-ready foods.
PubMed:
Hydrogen peroxide causes RAD9-dependent cell cycle arrest in G2 in Saccharomyces cerevisiae whereas menadione causes G1 arrest independent of RAD9 function.
PubMed:
Developmental toxicity of carbendazim: comparison of no-observed-adverse-effect level and benchmark dose approach.
PubMed:
High-performance liquid chromatographic determination of benomyl and carbendazim residues in apiarian samples.
PubMed:
Chromatographic analysis of imazalil and carbendazim in fruits. Method validation and residue monitoring program 1995.
PubMed:
Changes of bromopropylate and carbendazim residues during processing of apples into apple puree.
PubMed:
Determination of thiabendazole in fruits and vegetables by competitive-inhibition enzyme immunoassay.
PubMed:
Determination of methyl 2-benzimidazolecarbamate in bulk fruit juice concentrates by competitive-inhibition enzyme immunoassay.
PubMed:
Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet.
PubMed:
Determination of methyl 2-benzimidazolecarbamate in wine by competitive inhibition enzyme immunoassay.
PubMed:
Comparison of HPTLC and HPLC procedures for the determination of certain xenobiotic residues in apples and pears.
PubMed:
Determination of carbendazim in blueberries by reversed-phase high-performance liquid chromatography.
PubMed:
Inhibitory action of benzimidazole fungicides on the in vivo incorporation of [3H]thymidine in various organs of the mouse.
PubMed:
Ion-pairing liquid chromatographic determination of benzimidazole fungicides in foods.
PubMed:
The feasibility of using Chinese hamsters as an animal model for aneuploidy.
PubMed:
[Toxicological evaluation of pesticide and chemical residues in control of biological processes in vegetables under glass and plastics].
PubMed:
Pesticides and other chemical residues in Dutch total diet samples (June 1976-July 1978).
PubMed:
Simultaneous dermal exposure to captan and benomyl by strawberry harvesters.
PubMed:
[Orienting residue test of post-harvest treated white cabbage heads for benomoyl/carbendazim].
PubMed:
Determination of thiophanate methyl as carbendazin by high-pressure liquid chromatography: application to onions and cabbage.
PubMed:
Determination of methyl 2-benzimidazolylcarbamate in black walnut fruit.
PubMed:
Fate of benomyl and its degradation compound methyl 2-benzimidazolecarbamate on apple foliage.
PubMed:
a radioimmunoassay for benomyl and methyl 2-benzimidazolecarbamate on food crops.
PubMed:
Determination of benomyl, carbendazim and 2-aminobenzimidazole (2-ab) in plant materials. Part I: Apples, red-currants, grapes, kale and sugar beets.