Identification

Namecellulose microcrystalline
CAS Number9004-34-6
FDA UNIISMD1X3XO9M
Molecular Formulaunspecified
MDL NumberMFCD00081512

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 310
JECFA Food AdditiveMicrocrystalline Cellulose
GSFA CodexMicrocrystalline cellulose (Cellulose gel) (460(i))
DG SANTE Food Additivescellulose powder
DG SANTE Food Contact Materialscellulose powder
FDA Mainterm (SATF)977005-28-9 ; CELLULOSE, MICROCRYSTALLINE
FDA Mainterm (IAUFC)977005-28-9 ; CELLULOSE

Physical Properties

Appearance white crystalline powder (est)
Assay 92.00 to 100.00
Food Chemicals Codex Listed No
Soluble in sodium hydroxide solution, slightly
Insoluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesabsorbents

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 > 5000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 2000 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 5800 mg/m3/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemulsifiers, stabilizers, anticaking agents, dispersing agents
Recommendation for cellulose microcrystalline usage levels up tonot for fragrance use.
Recommendation for cellulose microcrystalline flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

View All Website (800) 238-0001 info@aicma.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Potential Uses

absorbents opacifying agents viscosity controlling agents

Natural Occurrence

not found in nature

Synonyms

beta- amylose alpha- cellulose cellulose fiber cellulose powder cellulose respirable fraction cellulose, microcrystalline cupricellulose potato fiber hydroxycellulose microcrystalline cellulose US Patents: 8,119,175 - Alginate matrix particles PubMed: Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. PubMed: Multifunctional PLA-PHB/cellulose nanocrystal films: processing, structural and thermal properties. PubMed: Efficient hydrolysis of cellulose over a novel sucralose-derived solid acid with cellulose-binding and catalytic sites. PubMed: The effect of ball milling and rehydration on powdered mixtures of hydrocolloids. PubMed: Transcriptional analysis of selected cellulose-acting enzymes encoding genes of the white-rot fungus Dichomitus squalens on spruce wood and microcrystalline cellulose. PubMed: Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice. PubMed: Plasma and hepatic cholesterol-lowering effects of tomato pomace, tomato seed oil and defatted tomato seed in hamsters fed with high-fat diets. PubMed: Cellulase production from a new strain Acremonium strictum isolated from the Brazilian Biome using different substrates. PubMed: Cloning and identification of novel hydrolase genes from a dairy cow rumen metagenomic library and characterization of a cellulase gene. PubMed: Impact of carboxymethyl cellulose (CMC) and microcrystalline cellulose (MCC) on functional characteristics of emulsified sausages. PubMed: [Interaction of the dietary fibers with different functional food ingredients]. PubMed: Case studies with new excipients: development, implementation and regulatory approval. PubMed: HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice. PubMed: Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model. PubMed: Digestibility, fermentability, and energy value of highly cross-linked phosphate tapioca starch in men. PubMed: In-vitro and in-vivo binding activity of chicken egg yolk immunoglobulin Y (IgY) against gliadin in food matrix. PubMed: Characterization of critical physical and mechanical properties of freeze-dried grape powder for development of a clinical patient delivery system. PubMed: Investigation into the potential ability of Pickering emulsions (food-grade particles) to enhance the oxidative stability of oil-in-water emulsions. PubMed: Dietary hydroxypropyl methylcellulose increases excretion of saturated and trans fats by hamsters fed fast food diets. PubMed: Interaction of microbial β-glucuronidase with vegetable pectins. PubMed: A minimal set of bacterial cellulases for consolidated bioprocessing of lignocellulose. PubMed: Supplementation of hydroxypropyl methylcellulose into yeast leavened all-whole grain barley bread potentiates cholesterol-lowering effect. PubMed: Non-wood Fibre Production of Microcrystalline Cellulose from Sorghum caudatum: Characterisation and Tableting Properties. PubMed: Oxidized cellulose binding to allergens with a carbohydrate-binding module attenuates allergic reactions. PubMed: Development and characterization of food-grade tracers for the global grain tracing and recall system. PubMed: Adsorption of monocomponent enzymes in enzyme mixture analyzed quantitatively during hydrolysis of lignocellulose substrates. PubMed: Bacteriophage-based biosorbents coupled with bioluminescent ATP assay for rapid concentration and detection of Escherichia coli. PubMed: [Effect of microcrystalline cellulose and wheat bran on growth rates and on biological value, assimilated protein and lipid metabolism]. PubMed: Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters. PubMed: Cecal and colonic responses in rats fed 5 or 30% corn oil diets containing either 7.5% broccoli dietary fiber or microcrystalline cellulose. PubMed: Changes in submicrometer structure of enzymatically hydrolyzed microcrystalline cellulose. PubMed: Application of crustacean chitin as a co-diluent in direct compression of tablets. PubMed: Composite edible films based on hydroxypropyl methylcellulose reinforced with microcrystalline cellulose nanoparticles. PubMed: Purification of plant-derived antibodies through direct immobilization of affinity ligands on cellulose. PubMed: Hepatic gene expression related to lower plasma cholesterol in hamsters fed high-fat diets supplemented with blueberry peels and peel extract. PubMed: Effect of yeast strain and fermentation conditions on the release of cell wall polysaccharides. PubMed: Interfacial elastic relaxation during the ejection of bi-layered tablets. PubMed: One hundred years of commercial food carbohydrates in the United States. PubMed: Computational simulations of the Trichoderma reesei cellobiohydrolase I acting on microcrystalline cellulose Ibeta: the enzyme-substrate complex. PubMed: [Microcrystalline cellulose and their flow -- morphological properties modifications as an effective excpients in tablet formulation technology containing lattice established API and also dry plant extract]. PubMed: Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients. PubMed: Direct compression properties of chitin and chitosan. PubMed: Pretreatment of microcrystalline cellulose flakes with CaCl2 increases the surface area, and thus improves enzymatic saccharification. PubMed: Sauces and dressings: a review of properties and applications. PubMed: Effects of microcrystalline cellulose on functional properties of hydroxy propyl methyl cellulose microcomposite films. PubMed: Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS. PubMed: Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets. PubMed: Pulmonary disease due to aspiration of food and other particulate matter: a clinicopathologic study of 59 cases diagnosed on biopsy or resection specimens. PubMed: Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. PubMed: Computer simulation studies of microcrystalline cellulose Ibeta. PubMed: Bifidogenic effect of dietary fiber and resistant starch from leguminous on the intestinal microbiota of rats. PubMed: Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process. PubMed: Cellulose-based chromatography for cellooligosaccharide production. PubMed: Quantitative analysis of cellulose-reducing ends. PubMed: Energetics for displacing a single chain from the surface of microcrystalline cellulose into the active site of Acidothermus cellulolyticus Cel5A. PubMed: Replacement of immobilised cell bioreactors by smaller immobilised enzyme bioreactors: unique-outcome predictability for cytochromes P450 isoforms? PubMed: Production of cellulose II from native cellulose by near- and supercritical water solubilization. PubMed: Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. PubMed: Cloning, sequencing, and heterologous expression of a cellobiohydrolase cDNA from the basidiomycete Corticium rolfsii. PubMed: Oxidation of 4-bromophenol by the recombinant fused protein cellulose-binding domain-horseradish peroxidase immobilized on cellulose. PubMed: Dietary fiber-rich barley products beneficially affect the intestinal tract of rats. PubMed: Cholesterol-lowering effect of spreads enriched with microcrystalline plant sterols in hypercholesterolemic subjects. PubMed: Submerged cultivation of scytalidium thermophilum on complex lignocellulosic biomass for endoglucanase production. PubMed: Expression, refolding and indirect immobilization of horseradish peroxidase (HRP) to cellulose via a phage-selected peptide and cellulose-binding domain (CBD). PubMed: Effects of some hydrocolloids and water activity on nonenzymic browning of concentrated orange juice. PubMed: A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module. PubMed: Structure and dry binding activity of different polymers, including Kollidon VA 64. PubMed: Microcrystalline cellulose from soybean husk: effects of solvent treatments on its properties as acetylsalicylic acid carrier. PubMed: Avicel-adsorbable endoglucanase production by the thermophilic fungus Scytalidium thermophilum type culture Torula thermophila. PubMed: Changes in fecal microflora induced by intubation of mice with Bacillus subtilis (natto) spores are dependent upon dietary components. PubMed: Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. PubMed: Modes of action on cotton and bacterial cellulose of a homologous endoglucanase-exoglucanase pair from Trichoderma reesei. PubMed: Trichoderma reesei cellobiohydrolase I with an endoglucanase cellulose-binding domain: action on bacterial microcrystalline cellulose. PubMed: Qualitative investigation of uptake of fine particle size microcrystalline cellulose following oral administration in rats. PubMed: The cellulose-binding domain of the major cellobiohydrolase of Trichoderma reesei exhibits true reversibility and a high exchange rate on crystalline cellulose. PubMed: Characterization of a double cellulose-binding domain. Synergistic high affinity binding to crystalline cellulose. PubMed: Development of a new series of agricultural/food reference materials for analytical quality control of elemental determinations. PubMed: Simultaneous production and induction of cellulolytic and xylanolytic enzymes in aStreptomyces sp. PubMed: The effect of Trichoderma viride C-1 UV mutagenization on cellulases activity. PubMed: Influence of cellulose structure on its digestibility in the rat. PubMed: A model of enzyme adsorption and hydrolysis of microcrystalline cellulose with slow deactivation of the adsorbed enzyme. PubMed: Inhibition of lipolytic activity in milk by polysaccharides. PubMed: Polysaccharide degrading enzymes of a toxigenic strain of Aspergillus clavatus from Nigerian poultry feeds. PubMed: Liquid chromatographic analysis of enviradene, a new antiviral agent, in plasma and its application in bioavailability studies in the dog. PubMed: The effect of the oxygen transfer rate (OSR) on the formation of cellulases by Trichoderma viride in submersion culture. PubMed: Lignocellulolytic Enzymes Produced by Volvariella volvacea, the Edible Straw Mushroom. PubMed: Gastroscopic and pharmacokinetic evaluation of a new pivmecillinam tablet. PubMed: Low calorie bulking agents. PubMed: Methylguanidine content in food. PubMed: Microcrystalline cellulose replacement in cakes and biscuits. PubMed: [Safe use of microcrystalline cellulose in low-calorie foods]. PubMed: [Absorption of microcrystalline cellulose].