chelidonic acid
4-oxo-4H-pyran-2,6-dicarboxylic acid
Identification
| Name | chelidonic acid |
| IUPAC | 4-oxopyran-2,6-dicarboxylic acid |
| CAS Number | 99-32-1 |
| EINECS | 202-749-0 |
| FDA UNII | T33U4W5K6O |
| Molecular Formula | C7 H4 O6 |
| Molecular Weight | 184.10408000 |
| MDL Number | MFCD00006577 |
| Nikkaji Number | J4.968I |
| Beilstein | 0163607 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 262.00 °C. @ 760.00 mm Hg |
| Boiling Point | 471.34 °C. @ 760.00 mm Hg (est) |
| Flash Point | 399.00 °F. TCC ( 204.10 °C. ) (est) |
| logP (o/w) | -0.746 (est) |
| Soluble in | water, 7111 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LDLo 500 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for chelidonic acid usage levels up to | not for fragrance use. |
| Recommendation for chelidonic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
chelidonicacid
2,6-
dicarboxyl-4-pyrone
jerva acid
jervaic acid
jervasic acid
4-oxo
pyran-2,6-dicarboxylic acid
4-oxo-1,4-
pyran-2,6-dicarboxylic acid
4-oxo-4H-
pyran-2,6-dicarboxylic acid
4H-
pyran-2,6-dicarboxylic acid, 4-oxo-
PubMed:
The therapeutic effect of chelidonic acid on ulcerative colitis.
PubMed:
Statistically disordered short hydrogen bonds in (pipzH2)(cdoH)2 and a comparison with (pipzH2)(cdo)·H2O (pipz is piperazine and cdoH2 is chelidonic acid).
PubMed:
Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells.
PubMed:
Beneficial effects of chelidonic acid on a model of allergic rhinitis.
PubMed:
Cationic, neutral and anionic metal(II) complexes derived from 4-oxo-4H-pyran-2,6-dicarboxylic acid (chelidonic acid).
PubMed:
Tracer studies with 13C-labeled carbohydrates in cultured plant cells. Retrobiosynthetic analysis of chelidonic acid biosynthesis.
PubMed:
An investigation of the irritant and allergenic properties of daffodils (Narcissus pseudonarcissus L., Amaryllidaceae). A review of daffodil dermatitis.
PubMed:
Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase.
PubMed:
[Reaction of chelidonic acid with o-phenylenediamine].
PubMed:
The biosynthesis of chelidonic acid.
PubMed:
Biosynthesis of chelidonic acid. I. Preliminary observation on the precursors of chelidonic acid in Convallaria majalis L.
PubMed:
[Reactions with chelidonic acid. 3. On re-arrangements of pyranylidene-carbonic acid derivatives with diamines. 10. Studies on gamma-pyrones].
PubMed:
[CONSTITUENTS OF CONVALLARIA. 3. ISOLATION OF CHELIDONIC ACID].
PubMed:
[REACTIONS WITH CHELIDONIC ACID. II. 9. ON STUDIES ON GAMMA-PYRONES].
PubMed:
Dissociation constants of certain gamma-pyrone dicarboxylic acids. Meconic acid and chelidonic acid.
PubMed:
[Possible analytical determination of chelidonic acid in vegetable material].
PubMed:
[Occurrence and distribution of chelidonic acid in various plant families].
PubMed:
[Tannic acid microreactions of meconic acid alkaloids of opium and of chelidonic acid celandine alkaloids; their differentiation and application].