hydrochlorofluorocarbon 22

chlorodifluoromethane

CAS: 75-45-6 C H Cl F2 MW: 86.46777640

Identification

Namehydrochlorofluorocarbon 22
IUPACchloro(difluoro)methane
CAS Number75-45-6
EINECS200-871-9
FDA UNIIZFO627O6CN
Molecular FormulaC H Cl F2
Molecular Weight86.46777640
MDL NumberMFCD00000821
Nikkaji NumberJ1.455I
Beilstein1731036

Regulatory

DG SANTE Food Contact Materialschlorodifluoromethane

Physical Properties

Appearance colorless gas (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point -157.42 °C. @ 760.00 mm Hg (est)
Boiling Point -38.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure 7250.000000 mmHg @ 25.00 °C. (est)
Vapor Density 3 ( Air = 1 )
Flash Point -129.00 °F. TCC ( -89.40 °C. ) (est)
logP (o/w) 1.080
Soluble in water, 2770 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespropellants

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-rat LD > 43200 ug/kg
Dermal ToxicityNot determined
Inhalation Toxicityinhalation-dog LCLo 70 pph

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: ATAXIA']

Safety in Use

Categorypropellants, aerating agents, and gas
Recommendation for hydrochlorofluorocarbon 22 usage levels up tonot for fragrance use.
Recommendation for hydrochlorofluorocarbon 22 flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

propellants

Natural Occurrence

not found in nature

Synonyms

algeon 22 algofrene 22 algofrene type 6 arcton 22 arcton 4 CFC 22 chloro(difluoro)methane chlorodifluoromethane mono- chlorodifluoromethane chlorodifluoromethane [R22] [UN1018] [Nonflammable gas] chlorofluorocarbon 22 daiflon 22 difluorochloromethane difluoromonochloromethane dymel 22 electro-CF 22 eskimon 22 F 22 (halocarbon) FC 22 FKW 22 flugene 22 fluorocarbon-22 forane 22 forane 22 B freon 22 frigen 22 genetron 22 haltron 22 HCFC 22 HCFC-22 HFA-22 HSDB 143 isceon 22 isotron 22 khladon 22 methane, chlorodifluoro- propellant 22 R 22 (refrigerant) racon 22 refrigerant R 22 ucon 22 PubMed: Asphyxiation fatality exposure from chlorodifluoromethane. PubMed: Determination of partition coefficients of refrigerants by gas liquid chromatographic headspace analysis. PubMed: High-temperature hydrodechlorination of ozone-depleting chlorodifluoromethane (HCFC-22) on supported Pd and Ni catalysts. PubMed: The structure and interaction energies of the weak complexes of CHClF2 and CHF3 with HCCH: a test of density functional theory methods. PubMed: 'Virgin gas' ban demands user rethink. PubMed: [Determination of chlorodifluoromethane in air of work places with gas chromatography]. PubMed: An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay. PubMed: Difluoromethyltrialkylammonium salts--their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process. PubMed: Simultaneous conversion of CHClF(2) and CH(3)Br to CH(2)CF(2). PubMed: An accidental death due to Freon 22 (monochlorodifluoromethane) inhalation in a fishing vessel. PubMed: Jet spectroscopy of arylmethyl radicals in the visible region: assignment of low-frequency vibrational modes in diphenylmethyl and chlorodiphenylmethyl radicals. PubMed: Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases. PubMed: Quantification of the refrigerants R22 and R134a in mixtures by means of different polymers and reflectometric interference spectroscopy. PubMed: Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction. PubMed: Improper or classical hydrogen bonding? A comparative cryosolutions infrared study of the complexes of HCClF(2), HCCl(2)F, and HCCl(3) with dimethyl ether. PubMed: [Measurement of chlorodifluoromethane(HCFC-22) in the atmosphere by using an O2-induced electron capture detector (ECD)]. PubMed: In situ X-ray diffraction and solid-state NMR study of the fluorination of gamma-Al(2)O(3) with HCF(2)Cl. PubMed: A sensitive neutron dosimeter using superheated liquid. PubMed: Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons. PubMed: Chlorodifluoromethane. PubMed: Frigen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid. PubMed: Facial injury and airway threat from inhalant abuse: a case report. PubMed: Cryogen spray cooling during Nd:YAG laser treatment of hemangiomas. A preliminary animal model study. PubMed: Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models. PubMed: The influence of sleeping position on functional residual capacity and effective pulmonary blood flow in healthy neonates. PubMed: Headspace GC/MS testing for chlorodifluoromethane in two fatal cases. PubMed: Secondary arterial hypertension linked to Freon exposure. PubMed: Occupational phosgene poisoning: a case report and review. PubMed: Evaluation of sampling and analytical methods for the determination of chlorodifluoromethane in air. PubMed: Fatality due to recreational use of chlorodifluoromethane and chloropentafluoroethane. PubMed: [Sudden death caused by freon 22?]. PubMed: Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22). PubMed: Comparison of estimates of cardiac output by indicator dilution and freon 22 uptake during gas mixing in dogs. PubMed: [Temperature profile in the enamel during cold tests]. PubMed: Behavioural thermoregulation in mice: effects of low doses of general anaesthetics of different potency. PubMed: Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats. PubMed: Sloping alveolar plateaus of CO2, O2, and intravenously infused C2H2 and CHClF2 in the dog. PubMed: Cooling rate and ice-crystal measurement in biological specimens plunged into liquid ethane, propane, and Freon 22. PubMed: Expirograms of O2, CO2 and intravenously infused C2H2 and Freon-22 during panting in dogs. PubMed: Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons. PubMed: Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons. PubMed: Effects of environmental O2 on blood flow and diffusing capacity in amphibian skin. PubMed: Solubility of Freon 22 in human blood and lung tissue. PubMed: Solubility of freon-22 in blood and lung tissue. PubMed: The sloping alveolar plateau of tracer gases washed out from mixed venous blood in man. PubMed: Cerebral blood flow measured by NMR indicator dilution in cats. PubMed: [A toxicological study of the effects of freon 22 inhalation--the behavior of rats exposed to freon inhalation and an evaluation of freon concentrations in their tissue]. PubMed: Elimination kinetics of acetylene and Freon 22 in resting and active lungless salamanders. PubMed: Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice. PubMed: Diffusion-related differences in elimination of inert gases from the lung. PubMed: Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22). PubMed: Chlorodifluoromethane. PubMed: The relevance for man of animal data on reproductive toxicity of industrial chemicals. PubMed: [Effects of the use of FRIGEN (AG-Ffm-HOECST) on the determination of blood levels of some proteins (IgA, IgM, IgG, C3c, C4) in cord blood of healthy newborn infants at term by laser nephelometry]. PubMed: The toxicological evaluation of chlorofluorocarbon 22 (CFC 22). PubMed: Role of diffusion-dependent gas inhomogeneity in gas exchange in the dog. PubMed: Acute toxicity of fluorocarbon-22: toxic symptoms, lethal concentration, and its fate in rabbit and mouse. PubMed: Studies on the male reproductive toxicity of Freon 22.