hydrochlorofluorocarbon 22
chlorodifluoromethane
Identification
| Name | hydrochlorofluorocarbon 22 |
| IUPAC | chloro(difluoro)methane |
| CAS Number | 75-45-6 |
| EINECS | 200-871-9 |
| FDA UNII | ZFO627O6CN |
| Molecular Formula | C H Cl F2 |
| Molecular Weight | 86.46777640 |
| MDL Number | MFCD00000821 |
| Nikkaji Number | J1.455I |
| Beilstein | 1731036 |
Regulatory
| DG SANTE Food Contact Materials | chlorodifluoromethane |
Physical Properties
| Appearance | colorless gas (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | -157.42 °C. @ 760.00 mm Hg (est) |
| Boiling Point | -38.10 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 7250.000000 mmHg @ 25.00 °C. (est) |
| Vapor Density | 3 ( Air = 1 ) |
| Flash Point | -129.00 °F. TCC ( -89.40 °C. ) (est) |
| logP (o/w) | 1.080 |
| Soluble in | water, 2770 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | propellants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-rat LD > 43200 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | inhalation-dog LCLo 70 pph |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: ATAXIA']
Safety in Use
| Category | propellants, aerating agents, and gas |
| Recommendation for hydrochlorofluorocarbon 22 usage levels up to | not for fragrance use. |
| Recommendation for hydrochlorofluorocarbon 22 flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
algeon 22
algofrene 22
algofrene type 6
arcton 22
arcton 4
CFC 22
chloro(difluoro)methane
chlorodifluoromethane
mono-
chlorodifluoromethane
chlorodifluoromethane [R22] [UN1018] [Nonflammable gas]
chlorofluorocarbon 22
daiflon 22
difluorochloromethane
difluoromonochloromethane
dymel 22
electro-CF 22
eskimon 22
F 22 (halocarbon)
FC 22
FKW 22
flugene 22
fluorocarbon-22
forane 22
forane 22 B
freon 22
frigen 22
genetron 22
haltron 22
HCFC 22
HCFC-22
HFA-22
HSDB 143
isceon 22
isotron 22
khladon 22
methane, chlorodifluoro-
propellant 22
R 22 (refrigerant)
racon 22
refrigerant R 22
ucon 22
PubMed:
Asphyxiation fatality exposure from chlorodifluoromethane.
PubMed:
Determination of partition coefficients of refrigerants by gas liquid chromatographic headspace analysis.
PubMed:
High-temperature hydrodechlorination of ozone-depleting chlorodifluoromethane (HCFC-22) on supported Pd and Ni catalysts.
PubMed:
The structure and interaction energies of the weak complexes of CHClF2 and CHF3 with HCCH: a test of density functional theory methods.
PubMed:
'Virgin gas' ban demands user rethink.
PubMed:
[Determination of chlorodifluoromethane in air of work places with gas chromatography].
PubMed:
An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay.
PubMed:
Difluoromethyltrialkylammonium salts--their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process.
PubMed:
Simultaneous conversion of CHClF(2) and CH(3)Br to CH(2)CF(2).
PubMed:
An accidental death due to Freon 22 (monochlorodifluoromethane) inhalation in a fishing vessel.
PubMed:
Jet spectroscopy of arylmethyl radicals in the visible region: assignment of low-frequency vibrational modes in diphenylmethyl and chlorodiphenylmethyl radicals.
PubMed:
Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases.
PubMed:
Quantification of the refrigerants R22 and R134a in mixtures by means of different polymers and reflectometric interference spectroscopy.
PubMed:
Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction.
PubMed:
Improper or classical hydrogen bonding? A comparative cryosolutions infrared study of the complexes of HCClF(2), HCCl(2)F, and HCCl(3) with dimethyl ether.
PubMed:
[Measurement of chlorodifluoromethane(HCFC-22) in the atmosphere by using an O2-induced electron capture detector (ECD)].
PubMed:
In situ X-ray diffraction and solid-state NMR study of the fluorination of gamma-Al(2)O(3) with HCF(2)Cl.
PubMed:
A sensitive neutron dosimeter using superheated liquid.
PubMed:
Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons.
PubMed:
Chlorodifluoromethane.
PubMed:
Frigen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid.
PubMed:
Facial injury and airway threat from inhalant abuse: a case report.
PubMed:
Cryogen spray cooling during Nd:YAG laser treatment of hemangiomas. A preliminary animal model study.
PubMed:
Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models.
PubMed:
The influence of sleeping position on functional residual capacity and effective pulmonary blood flow in healthy neonates.
PubMed:
Headspace GC/MS testing for chlorodifluoromethane in two fatal cases.
PubMed:
Secondary arterial hypertension linked to Freon exposure.
PubMed:
Occupational phosgene poisoning: a case report and review.
PubMed:
Evaluation of sampling and analytical methods for the determination of chlorodifluoromethane in air.
PubMed:
Fatality due to recreational use of chlorodifluoromethane and chloropentafluoroethane.
PubMed:
[Sudden death caused by freon 22?].
PubMed:
Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22).
PubMed:
Comparison of estimates of cardiac output by indicator dilution and freon 22 uptake during gas mixing in dogs.
PubMed:
[Temperature profile in the enamel during cold tests].
PubMed:
Behavioural thermoregulation in mice: effects of low doses of general anaesthetics of different potency.
PubMed:
Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats.
PubMed:
Sloping alveolar plateaus of CO2, O2, and intravenously infused C2H2 and CHClF2 in the dog.
PubMed:
Cooling rate and ice-crystal measurement in biological specimens plunged into liquid ethane, propane, and Freon 22.
PubMed:
Expirograms of O2, CO2 and intravenously infused C2H2 and Freon-22 during panting in dogs.
PubMed:
Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons.
PubMed:
Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons.
PubMed:
Effects of environmental O2 on blood flow and diffusing capacity in amphibian skin.
PubMed:
Solubility of Freon 22 in human blood and lung tissue.
PubMed:
Solubility of freon-22 in blood and lung tissue.
PubMed:
The sloping alveolar plateau of tracer gases washed out from mixed venous blood in man.
PubMed:
Cerebral blood flow measured by NMR indicator dilution in cats.
PubMed:
[A toxicological study of the effects of freon 22 inhalation--the behavior of rats exposed to freon inhalation and an evaluation of freon concentrations in their tissue].
PubMed:
Elimination kinetics of acetylene and Freon 22 in resting and active lungless salamanders.
PubMed:
Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice.
PubMed:
Diffusion-related differences in elimination of inert gases from the lung.
PubMed:
Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22).
PubMed:
Chlorodifluoromethane.
PubMed:
The relevance for man of animal data on reproductive toxicity of industrial chemicals.
PubMed:
[Effects of the use of FRIGEN (AG-Ffm-HOECST) on the determination of blood levels of some proteins (IgA, IgM, IgG, C3c, C4) in cord blood of healthy newborn infants at term by laser nephelometry].
PubMed:
The toxicological evaluation of chlorofluorocarbon 22 (CFC 22).
PubMed:
Role of diffusion-dependent gas inhomogeneity in gas exchange in the dog.
PubMed:
Acute toxicity of fluorocarbon-22: toxic symptoms, lethal concentration, and its fate in rabbit and mouse.
PubMed:
Studies on the male reproductive toxicity of Freon 22.