colcemid
demecolcine
Identification
| Name | colcemid |
| IUPAC | (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one |
| CAS Number | 477-30-5 |
| EINECS | 207-514-6 |
| FDA UNII | Z01IVE25KI |
| Molecular Formula | C21 H25 N O5 |
| Molecular Weight | 371.43325000 |
| MDL Number | MFCD00075459 |
| Nikkaji Number | J9.231B |
| Beilstein | 2822892 |
| XlogP3 | 1.40 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 3161 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for colcemid usage levels up to | not for fragrance use. |
| Recommendation for colcemid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-
deacetyl-N-methylcolchicine
demecolcin
demecolcine
N-
methyl-N-deacetylcolchicine
reichstein's F
substance F
(7S)-1,2,3,10-
tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
PubMed:
Evaluation of drugs and stationary growth on the cell cycle of Giardia intestinalis.
PubMed:
Nanocavity effect on photophysical properties of colchicine: a proof by circular dichroism study and picosecond time-resolved analysis in various reverse micellar assemblies.
PubMed:
[Cytogenetic characterization of the neotropical fish Brycon henni (Pisces: Characidae)].
PubMed:
[Comparison of TK gene mutation assay in TK6 and TK6-E6 cell induced by vinblastin and colcemid].
PubMed:
p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.
PubMed:
Flow cytometric analysis of the cell-cycle distribution of spleen lymphocytes isolated from Fischer 344 rats exposed to ethyl nitrosourea.
PubMed:
Cytoskeletal modulation of plasma membrane events induced by interferon-alpha.
PubMed:
[Immediate results of polychemotherapy in esophageal cancer patients].
PubMed:
Polyploidy and aneuploidy induced by colcemid in Drosophila melanogaster.
PubMed:
Effects of food seasonings on the cell cycle and chromosome morphology of mammalian cells in vitro with special reference to turmeric.
PubMed:
A new method of measuring the rate of shedding of epithelial cells from the intestinal villus of the rat.