colchicine

N-((7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7-trihydrobenzo[d]heptalen-7-yl)acetamide

CAS: 64-86-8 C22 H25 N O6 MW: 399.44345000

Identification

Namecolchicine
IUPACN-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
CAS Number64-86-8
EINECS200-598-5
FDA UNIISML2Y3J35T
Molecular FormulaC22 H25 N O6
Molecular Weight399.44345000
MDL NumberMFCD00078484
Nikkaji NumberJ9.267C
Beilstein2228813
XlogP31.00 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 156.00 °C. @ 760.00 mm Hg
Boiling Point 726.03 °C. @ 760.00 mm Hg (est)
Vapor Pressure 3.200000 mmHg @ 25.00 °C. (est)
Flash Point 739.00 °F. TCC ( 392.90 °C. ) (est)
logP (o/w) 1.300
Soluble in water, 4.50E+04 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-bird - wild LD50 31600 ug/kg
Dermal Toxicitysubcutaneous-cat LDLo 500 ug/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: SHOCK\nGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"\nVASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION', 'GASTROINTESTINAL: NAUSEA OR VOMITING\nBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)\nVASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for colchicine usage levels up tonot for fragrance use.
Recommendation for colchicine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

colchicum autumnale

Synonyms

acetamide, N- (5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)- acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide, N-(5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide, N-(5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)- acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- colbenemid colchicin (S)- colchicine 7-a-H- colchicine 7aH- colchicine colchicinum colchisol colsaloid condylon N-((7S)-5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide N-(5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide N-(5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide (S)-N-(5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide N-[(7S)-5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide N-((7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7-trihydrobenzo[d]heptalen-7-yl)acetamide N-((S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide (S)-N-(1,2,3,10- tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide PubMed: [ACCIDENTAL POISONING WITH A PLANT COLCHICUM AUTUMNALE: REPORT OF TWO CASES]. 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