cumene hydroperoxide

2-phenylpropan-2-yl hydroperoxide

CAS: 80-15-9 C9 H12 O2 MW: 152.19304000

Identification

Namecumene hydroperoxide
CAS Number80-15-9
EINECS201-254-7
FDA UNIIPG7JD54X4I
Molecular FormulaC9 H12 O2
Molecular Weight152.19304000
MDL NumberMFCD00002129
Nikkaji NumberJ2.835E
Beilstein1908117

Regulatory

FDA Mainterm (IAUFC)80-15-9 ; CUMENE HYDROPEROXIDE
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.03000 @ 25.00 °C.
Refractive Index 1.52100 @ 20.00 °C.
Melting Point -9.00 °C. @ 760.00 mm Hg
Boiling Point 225.00 to 226.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.003270 mmHg @ 25.00 °C.
Flash Point 133.00 °F. TCC ( 56.11 °C. )
logP (o/w) 2.216 (est)
Soluble in water, 1.39E+04 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 270 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 490 mg/kg
Inhalation Toxicityinhalation-mouse LC50 200 ppm/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryindirect food additives: adhesives and components of coatings
Recommendation for cumene hydroperoxide usage levels up tonot for fragrance use.
Recommendation for cumene hydroperoxide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

cumolhydroperoxide cumyl hydroperoxide cumylhydroperoxide a,a- dimethylbenzyl hydroperoxide a,a- dimethylbenzylhydroperoxide hydroperoxide, 1-methyl-1-phenylethyl hydroperoxide, a,a-dimethylbenzyl hydroperoxide, a,a-dimethylbenzyl- 2- hydroperoxy-2-phenylpropane 2- hydroperoxypropan-2-ylbenzene 1- methyl-1-phenyl ethyl hydroperoxide 1- methyl-1-phenylethyl hydroperoxide 1- methyl-1-phenylethylhydroperoxide 2- phenyl-2-propanyl hydroperoxide 2- phenyl-2-propyl hydroperoxide 2- phenylpropan-2-yl hydroperoxide PubMed: In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS. PubMed: Homologous overexpression of alkyl hydroperoxide reductase subunit C (ahpC) protects Bifidobacterium longum strain NCC2705 from oxidative stress. PubMed: The importance of Arabidopsis glutathione peroxidase 8 for protecting Arabidopsis plant and E. coli cells against oxidative stress. PubMed: Membranar effects exerted in vitro by polyphenols - quercetin, epigallocatechin gallate and curcumin - on HUVEC and Jurkat cells, relevant for diabetes mellitus. PubMed: Determination of total plasma hydroperoxides using a diphenyl-1-pyrenylphosphine fluorescent probe. PubMed: The role of plasmalogen in the oxidative stability of neutral lipids and phospholipids. PubMed: A search for hepatoprotective activity of aqueous extract of Rhus coriaria L. against oxidative stress cytotoxicity. PubMed: GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage. PubMed: Impact of apple polyphenols on GSTT2 gene expression, subsequent protection of DNA and modulation of proliferation using LT97 human colon adenoma cells. PubMed: Efficiency of hemoglobin from rainbow trout, cod, and herring in promotion of hydroperoxide-derived free radicals. PubMed: Heme-mediated production of free radicals via preformed lipid hydroperoxide fragmentation. PubMed: Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. PubMed: Amino acid and protein scavenging of radicals generated by iron/hydroperoxide system: an electron spin resonance spin trapping study. PubMed: Role of proteins in oil-in-water emulsions on the stability of lipid hydroperoxides. PubMed: Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica. PubMed: SigmaB activation under environmental and energy stress conditions in Listeria monocytogenes. PubMed: The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells. PubMed: Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. PubMed: RsbT and RsbV contribute to sigmaB-dependent survival under environmental, energy, and intracellular stress conditions in Listeria monocytogenes. PubMed: Effects of released iron, lipid peroxides, and ascorbate in trout hemoglobin-mediated lipid oxidation of washed cod muscle. PubMed: Oxidative stress response of rat testis to model prooxidants in vitro and its modulation. PubMed: Oxidative stress associated DNA damage in testis of mice: induction of abnormal sperms and effects on fertility. PubMed: Effect of natural phenolic acids on DNA oxidation in vitro. PubMed: Role of sigma(B) in heat, ethanol, acid, and oxidative stress resistance and during carbon starvation in Listeria monocytogenes. PubMed: Conjugated triene oxidation products of alpha-farnesene induce symptoms of superficial scald on stored apples. PubMed: Ability of surfactant headgroup size to alter lipid and antioxidant oxidation in oil-in-water emulsions. PubMed: Iron-accelerated cumene hydroperoxide decomposition in hexadecane and trilaurin emulsions. PubMed: Male-mediated dominant lethal mutations in mice following prooxidant treatment. PubMed: Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response. PubMed: Free radical scavenging and antioxidative properties of 'silibin' complexes on microsomal lipid peroxidation. PubMed: Ergosterol oxidation may be considered a signal for fungal growth and aflatoxin production in Aspergillus parasiticus. PubMed: Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity. PubMed: Glutathione content of the small intestine: regulation and function. PubMed: The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue. PubMed: Damage to protein synthesis concurrent with lipid peroxidation in rat liver slices: effect of halogenated compounds, peroxides, and vitamin E1. PubMed: Application of simulation modeling to lipid peroxidation processes. PubMed: Peroxides, genes and cancer.