(1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione

CAS: 458-37-7 C21 H20 O6 MW: 368.38560000

Identification

Namecurcumin
IUPAC(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
CAS Number458-37-7
EINECS207-280-5
FDA UNIIIT942ZTH98
Molecular FormulaC21 H20 O6
Molecular Weight368.38560000
MDL NumberMFCD00008365
Nikkaji NumberJ5.762B
Beilstein2306965

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 460
JECFA Food AdditiveCurcumin
GSFA CodexCurcumin (100(i))
DG SANTE Food Additivescurcumin

Physical Properties

Appearance orange yellow crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 181.00 to 183.00 °C. @ 760.00 mm Hg
logP (o/w) 3.290 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIng['cosmetic data2', 'cosmetic data']
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 > 2000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycoloring agents
Recommendation for curcumin usage levels up tonot for fragrance use.

American International Chemical, Inc.

Consistent sources

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Potential Uses

cosmetic colorants

Natural Occurrence

ginger plant ginger rhizome turmeric turmeric plant turmeric rhizome turmeric root turmeric sap turmeric tubers zedoary

Synonyms

c.i. 75300 C.I. natural yellow 3 ci 75300 CI natural yellow 3 curcumine curcuminoids purified from turmeric (curcuma longa l.) curcurmin 1,5- di(vanillyliden)acetylaceton 1,5- divanillyliden-2,4-pentandion 1,6- heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)- 1,6- heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)- (1E,6E)-1,7-bis[4- hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione (1E,6E)-1,7-bis(4- hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (E,E)-1,7-bis(4- hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (1E,6E)-1,7-bis(4- hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione 1,7-bis(4- hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione natural yellow 3 Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS PubMed: Encapsulation altered starch digestion: toward developing starch-based delivery systems. J-Stage: Antioxidation and Tyrosinase Inhibition of Polyphenolic Curcumin Analogs PubMed: Sensory evaluation of dry-fermented sausage containing ground deodorized yellow mustard. PubMed: Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation. PubMed: Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells. PubMed: Oxidative metabolites of curcumin poison human type II topoisomerases. PubMed: Induced mutation in β-CAROTENE HYDROXYLASE results in accumulation of β-carotene and conversion of red to orange color in pepper fruit. PubMed: Curcumin for the prevention of acute lung injury in sepsis: is it more than the flavor of the month? PubMed: Antioxidants in bakery products: a review. PubMed: Potential of spice-derived phytochemicals for cancer prevention. PubMed: Radioprotection and radiosensitization by curcumin. PubMed: Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. PubMed: Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. PubMed: Light reflected from colored mulches affects aroma and phenol content of sweet basil (Ocimum basilicum L.) leaves. PubMed: Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. PubMed: Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell.