Identification

Namecycloheptane
IUPACcycloheptane
CAS Number291-64-5
EINECS206-030-2
FDA UNIIVTZ53P34JA
Molecular FormulaC7 H14
Molecular Weight98.18858000
MDL NumberMFCD00004147
Nikkaji NumberJ43.272E
Beilstein1900279

Regulatory

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.81100 to 0.81400 @ 20.00 °C.
Pounds per Gallon - (est). 6.756 to 6.781
Refractive Index 1.44400 to 1.44600 @ 20.00 °C.
Flash Point 43.00 °F. TCC ( 6.11 °C. )
Soluble in water, 30 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for cycloheptane usage levels up tonot for fragrance use.
Recommendation for cycloheptane flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

heptamethylene suberane PubMed: Asymmetric Synthesis of Heterocyclic Analogues of a CGRP Receptor Antagonist for Treating Migraine. PubMed: Total synthesis of neodolastane diterpenes trichoaurantianolides C and D. PubMed: Exploitation of in situ generated sugar-based olefin keto-nitrones: synthesis of carbocycles, heterocycles, and nucleoside derivatives. PubMed: Preparation of cycloheptane ring by nucleophilic cyclopropanation of 1,2-diketones with bis(iodozincio)methane. PubMed: 2-(1-Aryliminoethyl)-9-arylimino-5,6,7,8-tetrahydrocycloheptapyridyl iron(II) dichloride: synthesis, characterization, and the highly active and tunable active species in ethylene polymerization. PubMed: SN2 regioselectivity in the esterification of 5- and 7-membered azacycloalkane quaternary salts: a DFT study to reveal the transition state ring conformation prevailing over the ground state ring strain. 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PubMed: Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. PubMed: Using a threading-followed-by-swelling approach to synthesize [2]rotaxanes. PubMed: Palladium-catalyzed decarboxylative [4 + 3] cyclization of gamma-methylidene-delta-valerolactones with 1,1-dicyanocyclopropanes. PubMed: Phase equilibria study of the binary systems (1-butyl-3-methylimidazolium thiocyanate ionic liquid + organic solvent or water). PubMed: Synthesis of vinylcycloheptadienes by the nickel-catalyzed three-component [3 + 2 + 2] cocyclization. Application to the synthesis of polycyclic compounds. PubMed: Stereochemistry and conformations of natural 1,2-epoxy-guaianolides based on 1D and 2D NMR data and semiempirical calculations. PubMed: One-pot catalytic asymmetric cascade synthesis of cycloheptane derivatives. PubMed: Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test. PubMed: Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: synthetic application to chiral seven-membered-ring alpha,alpha-disubstituted alpha-amino acid. PubMed: Beyond the corey reaction: one-step diolefination of cyclic ketones. PubMed: Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors. PubMed: Palladium-catalyzed synthesis of substituted cycloheptane-1,4-diones by an asymmetric ring-expanding allylation (AREA). PubMed: Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the forced swimming test. PubMed: Measurement and estimation of rate constants for the reactions of hydroxyl radical with several alkanes and cycloalkanes. PubMed: New enantioselective entry to cycloheptane amino acid polyols. PubMed: Absolute configuration and conformational disorder of a tricyclic thiosemicarbazone derivative. PubMed: 7-endo radical cyclizations catalyzed by titanocene(III). Straightforward synthesis of terpenoids with seven-membered carbocycles. PubMed: Concise synthesis of novel oxa-bridged compounds. PubMed: Silylcuprates from allene and their reaction with alpha,beta-unsaturatedd nitriles and imines. Synthesis of silylated oxo compounds leading to cyclopentane and cycloheptane ring formation. PubMed: 4,4'-Dimethyldinaphtho[a,d]cycloheptane, a naturally occurring polyaromatic derivative related to triterpenoids of the serratane series. PubMed: Hydrazulene ring systems via heteroatom-assisted [1,2]-shift of oxonium and sulfonium ylides. 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PubMed: Hydrogenolysis of cycloalkanes on a tantalum hydride complex supported on silica and insight into the deactivation pathway by the combined use of 1D solid-state NMR and EXAFS spectroscopies. PubMed: Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase. PubMed: Cyclopropanation with Fischer acyloxycarbene complexes: preparation of cyclopropane and cycloheptane-fused gamma-lactones. PubMed: Synthesis of enantiomerically pure, highly functionalized, medium-sized carbocycles from carbohydrates: formal total synthesis of (+)-calystegine b(2). PubMed: Alicyclobacillus herbarius sp. nov., a novel bacterium containing omega-cycloheptane fatty acids, isolated from herbal tea. PubMed: Reactions of oxalyl chloride with 1,2-cycloalkanediols in the presence of triethylamine. PubMed: Degradation of anthracene by bacteria isolated from oil polluted tropical soils. PubMed: Potential involvement of tyrosine kinase pathway in the antagonist induced upregulation of the NMDA receptor NR2B subunit in cortical neurons. PubMed: Specific alpha-galactosidase inhibitors, N-methylcalystegines--structure/activity relationships of calystegines from Lycium chinense. PubMed: Biosynthetic Studies of omega-Cycloheptyl Fatty Acids in Alicyclobacillus cycloheptanicus. Formation of Cycloheptanecarboxylic Acid from Phenylacetic Acid. PubMed: High-performance liquid chromatographic assay for the simultaneous determination of tramadol and its metabolites in microsomal fractions of human liver. PubMed: Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis. PubMed: Potential interference of cyclobenzaprine and norcyclobenzaprine with HPLC measurement of amitriptyline and nortriptyline: resolution by GC-MS analysis. PubMed: Differentiation between MK-801- and apomorphine-induced stereotyped behaviors in mice. PubMed: Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. PubMed: Stereochemistry of peptides containing 1-aminocycloheptane-1-carboxylic acid (Ac7c). PubMed: Metabolism of amineptine in rat, dog and man. PubMed: [Animal experimental studies on the pharmacology of a new anti-arrhythmic of the imino-cycloheptane series, stirocainide]. PubMed: Effects of a new antiarrhythmic compound [2-benzal-1-(2' diisopropyl-amino-ethoxy-imino)-cycloheptane hydrogen fumarate] on the electrophysiological properties of mammalian cardiac cells. PubMed: The metabolism of benzyclane [1-benzyl-1-(3-N,N-dimethylaminopropoxy)cycloheptane] in rat and man. PubMed: Action of bencyclane-hydrogen-fumarate on the carbohydrate metabolism of bovine lens homogenates. PubMed: Affinity chromatography of lipase with hydrophobic ligands coupled to cyanogen bromide-activated agarose. PubMed: [Halidor, 1-benzyl-1-(3'-dimethylaminopropoxy)-cyclohep tane fumarate as an uncoupler and inhibitor of the respiratory chain]. PubMed: [Treatment of peripheral circulation disorders with 1-benzyl-1-(3-dimethyl-amino-propoxy)-cycloheptane]. PubMed: Reaction of mono-bromo derivatives of cyclopentane, cyclohexane and cycloheptane and of related compounds with glutathione in vivo and the nature of the sulphur-containing metabolites excreted. PubMed: A new ganglion-stimulating compound: 2-imino-1,3-diaza-4-carboxyethyl cycloheptane hydrochloride (OG 30). PubMed: [Data to the pharmacology of 1-benzyl-1-(3'-dimethylamino-propoxy)-cycloheptane fumarate (EGYT-201)]. PubMed: Preferred conformations of the cycloheptane rings of A-homosteroids. PubMed: The heats of combustion of cyclopentane, cyclohexane, cycloheptane and cyclooctane.