cyclohexyl amine
hexahydrobenzenamine
Identification
| Name | cyclohexyl amine |
| IUPAC | cyclohexanamine |
| CAS Number | 108-91-8 |
| EINECS | 203-629-0 |
| FDA UNII | I6GH4W7AEG |
| Molecular Formula | C6 H13 N |
| Molecular Weight | 99.17661000 |
| MDL Number | MFCD00001486 |
| Nikkaji Number | J2.870C |
| Beilstein | 0471175 |
| XlogP3 | 1.50 (est) |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | FCN 1008 |
| DG SANTE Food Contact Materials | cyclohexylamine |
| FDA Mainterm (SATF) | 108-91-8 ; CYCLOHEXYLAMINE |
| FDA Regulation | FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.86700 to 0.86900 @ 20.00 °C. |
| Pounds per Gallon - (est). | 7.223 to 7.239 |
| Refractive Index | 1.45800 to 1.46000 @ 20.00 °C. |
| Melting Point | -17.00 °C. @ 760.00 mm Hg |
| Boiling Point | 134.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 10.000000 mmHg @ 22.00 °C. |
| Vapor Density | 3.42 ( Air = 1 ) |
| Flash Point | 81.00 °F. TCC ( 27.22 °C. ) |
| logP (o/w) | 1.490 |
| Soluble in | water, 1000000 mg/L @ 20 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | anticorrosive agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 11 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 320 ul/kg |
| Inhalation Toxicity | inhalation-rat LC50 7500 mg/m3 |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | boiler water additives used in the preparation of steam that will contact food |
| Recommendation for cyclohexyl amine usage levels up to | not for fragrance use. |
| Recommendation for cyclohexyl amine flavor usage levels up to | not for flavor use. |
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Exchange of knowledge
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Potential Uses
Natural Occurrence
Synonyms
1-
amino-cyclohexane
aminocyclohexane
1-
aminocyclohexane
aminohexahydrobenzene
benzenamine, hexahydro-
cyclohexanamine
cyclohexylamine
1-
cyclohexylamine
N-
cyclohexylamine
hexahydroaniline
hexahydrobenzenamine
PubMed:
Photodegradation of hexythiazox in different solvent systems under the influence of ultraviolet light and sunlight in the presence of TiO2, H2O2, and KNO3 and identification of the photometabolites.
PubMed:
Development and single-laboratory validation of an HPLC method for the determination of cyclamate sweetener in foodstuffs.
PubMed:
Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease.
PubMed:
Flow-injection determination of amine contaminants in cyclamate samples based on temperature for controlling selectivity.
PubMed:
Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans.
PubMed:
A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease.
PubMed:
Simultaneous derivatization and trapping of volatile products from aqueous photolysis of thiamethoxam insecticide.
PubMed:
Reaction of cyclohexylamine with hypochlorite and enhancement of oxidation of plasma sulfhydryl groups by hypochlorite in vitro.
PubMed:
[Sensitive and selective HPLC methods with prechromatographic derivatization for the determination of cyclamate in foods].
PubMed:
Effects of drugs that bind to PCP and sigma receptors on punished responding.
PubMed:
[Determination of cyclamate in complex matrix using HPLC after column derivatization with 4-fluoro-7-nitrobenzofurazan].
PubMed:
The metabolism and testicular toxicity of cyclohexylamine in rats and mice during chronic dietary administration.
PubMed:
[A new HPLC procedure for cyclamate in food with pre-chromatographic derivatization].
PubMed:
In-vitro and in-vivo formation of N-nitrosomethylcyclohexylamine from bromhexin and sodium nitrite, and DNA methylation in rats.
PubMed:
Metabolic adaptation of rat faecal microflora to cyclamate in vitro.
PubMed:
Studies of saccharin and cyclohexylamine in a coupled microsomal activating/embryo culture system.
PubMed:
Fatty-acid conjugation with cyclamate metabolites as a possible mechanism for ultimate retention.
PubMed:
Testicular responses of rats and dogs to cyclohexylamine overdosage.
PubMed:
Food additives.
PubMed:
Testicular effects of cyclohexylamine hydrochloride in the rat.
PubMed:
Long-term toxicity of cyclohexylamine hydrochloride in mice.
PubMed:
Long-term toxicity of cyclohexylamine hydrochloride in the rat.
PubMed:
Long-term and multigeneration toxicity studies with cyclohexylamine hydrochloride.
PubMed:
Lack of effect of blood sampling-induced haematopoiesis on in vivo chromosome damage by cyclohexylamine in chinese hamsters.
PubMed:
In vivo chromosome-damaging effect of cyclohexylamine in the chinese hamster.
PubMed:
Chronic toxicity study of cyclamate: saccharin (10: 1) in rats.
PubMed:
[Influence of several weeks' treatment of male and female mice with saccharin, cyclamate or cyclohexylamine sulfate on fertility and dominant lethal effects (author's transl)].
PubMed:
Short-term toxicity of cyclohexylamine hydrochloride in the rat.
PubMed:
[Cyclamate and cyclohexylamine--sweet and bitter].
PubMed:
In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
PubMed:
The determination of cyclohexylamine in cyclamates.
PubMed:
Cyclohexylamine excretors among human volunteers given cyclamate.