Identification

Namecyclohexyl amine
IUPACcyclohexanamine
CAS Number108-91-8
EINECS203-629-0
FDA UNIII6GH4W7AEG
Molecular FormulaC6 H13 N
Molecular Weight99.17661000
MDL NumberMFCD00001486
Nikkaji NumberJ2.870C
Beilstein0471175
XlogP31.50 (est)

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesFCN 1008
DG SANTE Food Contact Materialscyclohexylamine
FDA Mainterm (SATF)108-91-8 ; CYCLOHEXYLAMINE
FDA RegulationFDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.86700 to 0.86900 @ 20.00 °C.
Pounds per Gallon - (est). 7.223 to 7.239
Refractive Index 1.45800 to 1.46000 @ 20.00 °C.
Melting Point -17.00 °C. @ 760.00 mm Hg
Boiling Point 134.00 °C. @ 760.00 mm Hg
Vapor Pressure 10.000000 mmHg @ 22.00 °C.
Vapor Density 3.42 ( Air = 1 )
Flash Point 81.00 °F. TCC ( 27.22 °C. )
logP (o/w) 1.490
Soluble in water, 1000000 mg/L @ 20 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesanticorrosive agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 11 mg/kg
Dermal Toxicityskin-rabbit LD50 320 ul/kg
Inhalation Toxicityinhalation-rat LC50 7500 mg/m3

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryboiler water additives used in the preparation of steam that will contact food
Recommendation for cyclohexyl amine usage levels up tonot for fragrance use.
Recommendation for cyclohexyl amine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1- amino-cyclohexane aminocyclohexane 1- aminocyclohexane aminohexahydrobenzene benzenamine, hexahydro- cyclohexanamine cyclohexylamine 1- cyclohexylamine N- cyclohexylamine hexahydroaniline hexahydrobenzenamine PubMed: Photodegradation of hexythiazox in different solvent systems under the influence of ultraviolet light and sunlight in the presence of TiO2, H2O2, and KNO3 and identification of the photometabolites. PubMed: Development and single-laboratory validation of an HPLC method for the determination of cyclamate sweetener in foodstuffs. PubMed: Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. PubMed: Flow-injection determination of amine contaminants in cyclamate samples based on temperature for controlling selectivity. PubMed: Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans. PubMed: A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. PubMed: Simultaneous derivatization and trapping of volatile products from aqueous photolysis of thiamethoxam insecticide. PubMed: Reaction of cyclohexylamine with hypochlorite and enhancement of oxidation of plasma sulfhydryl groups by hypochlorite in vitro. PubMed: [Sensitive and selective HPLC methods with prechromatographic derivatization for the determination of cyclamate in foods]. PubMed: Effects of drugs that bind to PCP and sigma receptors on punished responding. PubMed: [Determination of cyclamate in complex matrix using HPLC after column derivatization with 4-fluoro-7-nitrobenzofurazan]. PubMed: The metabolism and testicular toxicity of cyclohexylamine in rats and mice during chronic dietary administration. PubMed: [A new HPLC procedure for cyclamate in food with pre-chromatographic derivatization]. PubMed: In-vitro and in-vivo formation of N-nitrosomethylcyclohexylamine from bromhexin and sodium nitrite, and DNA methylation in rats. PubMed: Metabolic adaptation of rat faecal microflora to cyclamate in vitro. PubMed: Studies of saccharin and cyclohexylamine in a coupled microsomal activating/embryo culture system. PubMed: Fatty-acid conjugation with cyclamate metabolites as a possible mechanism for ultimate retention. PubMed: Testicular responses of rats and dogs to cyclohexylamine overdosage. PubMed: Food additives. PubMed: Testicular effects of cyclohexylamine hydrochloride in the rat. PubMed: Long-term toxicity of cyclohexylamine hydrochloride in mice. PubMed: Long-term toxicity of cyclohexylamine hydrochloride in the rat. PubMed: Long-term and multigeneration toxicity studies with cyclohexylamine hydrochloride. PubMed: Lack of effect of blood sampling-induced haematopoiesis on in vivo chromosome damage by cyclohexylamine in chinese hamsters. PubMed: In vivo chromosome-damaging effect of cyclohexylamine in the chinese hamster. PubMed: Chronic toxicity study of cyclamate: saccharin (10: 1) in rats. PubMed: [Influence of several weeks' treatment of male and female mice with saccharin, cyclamate or cyclohexylamine sulfate on fertility and dominant lethal effects (author's transl)]. PubMed: Short-term toxicity of cyclohexylamine hydrochloride in the rat. PubMed: [Cyclamate and cyclohexylamine--sweet and bitter]. PubMed: In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine. PubMed: The determination of cyclohexylamine in cyclamates. PubMed: Cyclohexylamine excretors among human volunteers given cyclamate.