cyclopentyl amine
aminocyclopentane
Identification
| Name | cyclopentyl amine |
| IUPAC | cyclopentanamine |
| CAS Number | 1003-03-8 |
| EINECS | 213-697-3 |
| FDA UNII | 4259VRY3GN |
| Molecular Formula | C5 H11 N |
| Molecular Weight | 85.14967000 |
| MDL Number | MFCD00001380 |
| Nikkaji Number | J13.547J |
| Beilstein | 0635706 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.86000 to 0.86300 @ 20.00 °C. |
| Pounds per Gallon - (est). | 7.164 to 7.189 |
| Refractive Index | 1.44800 to 1.45100 @ 20.00 °C. |
| Melting Point | 82.70 °C. @ 760.00 mm Hg |
| Boiling Point | 108.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 24.187000 mmHg @ 25.00 °C. (est) |
| Flash Point | 63.00 °F. TCC ( 17.22 °C. ) |
| logP (o/w) | 0.973 (est) |
| Soluble in | water, 1.383e+005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-rat LDLo 100 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for cyclopentyl amine usage levels up to | not for fragrance use. |
| Recommendation for cyclopentyl amine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
aminocyclopentane
cyclopentanamine
cyclopentylamine
PubMed:
Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor.
PubMed:
Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.
PubMed:
A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation.
PubMed:
Inhibition of Lux quorum-sensing system by synthetic N-acyl-L-homoserine lactone analogous.
PubMed:
Nucleophilic reaction of cyclopentylamine on phthalimide derivatives: synthesis and antinociceptive activity of products.
PubMed:
Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists.
PubMed:
Carbocyclic ribosylamines: synthesis of 5-substituted carbocyclic beta-ribofuranosylamines.
PubMed:
Zeolite synthesis using degradable structure-directing agents and pore-filling agents.
PubMed:
Purification and characterization of a novel cyclohexylamine oxidase from the cyclohexylamine-degrading Brevibacterium oxydans IH-35A.
PubMed:
Amino substituted derivatives of 5'-amino-5'-deoxy-5'-noraristeromycin.
PubMed:
Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines.
PubMed:
Synthesis of carbocyclic phosphononucleosides.
PubMed:
Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C.
PubMed:
[The new antitumor drug cycloplatam: cytotoxicity and DNA interstrand cross-linking].
PubMed:
Different modes of inhibition by adamantane amine derivatives and natural polyamines of the functionally reconstituted influenza virus M2 proton channel protein.
PubMed:
Synthesis and Crystal Structures of Two Novel Anionic Aluminophosphates: A One-Dimensional Chain, UT-7 ([Al(3)P(5)O(20)H](5-)[C(7)H(13)NH(3)(+)](5)), and a Layer Containing Two Cyclic Amines, UT-8 ([Al(3)P(4)O(16)](3-)[C(4)H(7)NH(3)(+)](2)[C(5)H(10)NH(2)(+)]).
PubMed:
[Effect of anti-tumor agents cisplatin and cycloplatam on membrane protein kinase C activity in murine T-lymphocytes].
PubMed:
Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo.
PubMed:
[Synthesis of tert-butylcyclopentane-fused 1,3-oxazines and 1,3-thiazines].
PubMed:
Synthesis, characterization, and antitumor activity of amine platinum(II) and (IV) tellurate complexes.
PubMed:
Ammine/amine platinum (II) complexes effective in vivo against murine tumors sensitive or resistant to cisplatin and tetraplatin.
PubMed:
Synthesis and antitumor activity of ammine/amine platinum(II) and (IV) complexes.
PubMed:
Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.
PubMed:
Preclinical antitumor activity of orally administered platinum (IV) complexes.
PubMed:
Influenza virus M2 protein: a molecular modelling study of the ion channel.
PubMed:
Antiproliferative effect of complexes of platinum (II) with plasmanyl-(N-acyl)-ethanolamine, an inhibitor of protein kinase C.
PubMed:
Effect of the amine non-leaving group on the structure and stability of DNA complexes with cis-[Pt(R-NH2)2(NO3)2].
PubMed:
Modulation by polyamines of DNA-dependent DNA polymerase activity from human serum.
PubMed:
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides.
PubMed:
Structures of cis-amminedichloro(cyclopentylamine)platinum 0.25-hydrate and potassium trichloro(cyclopentylamine)platinate 0.5-hydrate.
PubMed:
Incorporation of cis-dichlorobiscyclopentylamineplatinum (II) into liposomes enhances its uptake by ADJ/PC6A tumour cells: comparative effects of the free and liposome-incorporated drug on the cyclic 3'-5' nucleotide phosphodiesterase activity.
PubMed:
Oxidative deamination of alicyclic primary amines by liver microsomes from rats and rabbits.
PubMed:
Carbocyclic glycinamide ribonucleotide is a substrate for glycinamide ribonucleotide transformylase.
PubMed:
Cytostatic and antitumour properties of a new series of Pt (II) complexes with cyclopentylamine.
PubMed:
Enantioselective synthesis of new analogues of neplanocin A.
PubMed:
Synthesis and peripheral cardiovascular action of cis- and trans-2-(3,4-dimethoxybenzyl)cyclopentylamine hydrochlorides.
PubMed:
Growth in vivo of l5178y-r murine leukaemic cells treated in vitro with cis-dichloro bis-(cyclopentylamine) platinum II.
PubMed:
Isobologram analysis of the combined effects of anti-tumour platinum complexes and ionizing radiation on mammalian cells.
PubMed:
Central nervous system actions of 2,5-bis(3,4-dimethoxybenzyl) cyclopentyl amine, a peripheral dopamine blocking agent.
PubMed:
Toxicity of platinum complexes on hemopoietic precursor cells.
PubMed:
Effect of platinum compounds on murine lymphocyte mitogenesis.
PubMed:
Antineoplastic activity of platinum complexes of trans-(dl)-1,2-cyclopentanediamine.
PubMed:
Response of two strains of L5178Y cells to cis-dichlorobis(cyclopentylamine)platinum(II). II. Differential effects of caffeine.
PubMed:
Response of two strains of L5178Y cells to cis-dichlorobis(cyclopentylamine)platinum(II). I. Cross-sensitivity to cis-PAD and UV light.
PubMed:
2,5-Bis(3,4-dimethoxybenzyl)cyclopentylamine, a peripheral dopamine blocking agent.
PubMed:
Metabolic studies of the nonnutritive sweeteners cyclopentylmethylsulfamate and cyclopentylsulfamate: determination of metabolites in rat urine.
PubMed:
Determination of the nonnutritive sweetener sodium cyclopentylsulfamate and three of its metabolites, cyclopentylamine, cyclopentanone, and cyclopentanol, in urine of rats and rabbits.
PubMed:
Action of a platinum complex [cis-dichlorobis (cyclopentylamine)-platinum (II)] on Chinese hamster ovary cells in vitro.
PubMed:
The effect of combined treatment with a platinum complex and ionizing radiation on chinese hamster ovary cells in vitro.
PubMed:
Proceedings: Cis-dichlorobis (cyclopentylamine) platinum II: action on CHO cells in vitro and interaction with ionizing radiation.