cyclopropyl amine

aminocyclopropane cyclopropanamine cyclopropylamine US Patents: 8,075,937 - Alkyldienamides exhibiting taste and sensory effect in flavor compositions PubMed: Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A. PubMed: Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. PubMed: Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors. PubMed: Experimental and theoretical investigation on the outer valence electronic structure of cyclopropylamine by (e, 2e) electron momentum spectroscopy. PubMed: Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates. PubMed: Highly stereoselective synthesis of (borylmethyl)cyclopropylamines by copper-catalyzed aminoboration of methylenecyclopropanes. PubMed: Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes. PubMed: Cell-intrinsic regulation of murine dendritic cell function and survival by prereceptor amplification of glucocorticoid. PubMed: Formal substitution of bromocyclopropanes with nitrogen nucleophiles. PubMed: Nazarov reactions of vinyl cyclopropylamines: an approach to the imino-Nazarov problem. PubMed: Highly enantioselective synthesis of cyclopropylamine derivatives via Ru(II)-pheox-catalyzed direct asymmetric cyclopropanation of vinylcarbamates. PubMed: KDM1 is a novel therapeutic target for the treatment of gliomas. PubMed: trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. PubMed: The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. PubMed: Simple and sensitive stability-indicating ion chromatography method for the determination of cyclopropylamine in nevirapine and moxifloxacin hydrochloride drug substances. PubMed: Electrochemical cleavage of sulfonamides: an efficient and tunable strategy to prevent β-fragmentation and epimerization. PubMed: Predicting biological functions of compounds based on chemical-chemical interactions. PubMed: Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase. PubMed: Intermolecular [3+2] cycloaddition of cyclopropylamines with olefins by visible-light photocatalysis. PubMed: A generalized graph-theoretical matrix of heterosystems and its application to the VMV procedure. PubMed: Oligodeoxynucleotides inhibit Toll-like receptor 3 mediated cytotoxicity and CXCL8 release in keratinocytes. PubMed: Stereoselective preparation of β,γ-methano-GABA derivatives. PubMed: Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride. PubMed: Administration route and carrier dependent effects on vaccine efficacy: implications for vaccine design. PubMed: Metal Complexes for DNA-Mediated Charge Transport. PubMed: Enantioselective syntheses of carbocyclic nuleosides 5'-homocarbovir, epi-4'-homocarbovir and their cyclopropylamine analogs using facially selective Pd-mediated allylations. PubMed: Adjuvant effect of cationic liposomes and CpG depends on administration route. PubMed: Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. PubMed: Cyclopropylamines from N,N-dialkylcarboxamides and Grignard reagents in the presence of titanium tetraisopropoxide or methyltitanium triisopropoxide. PubMed: A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation. PubMed: Scalable synthesis of a prostaglandin EP4 receptor antagonist. PubMed: Differences between amine- and phosphine-boranes: synthesis, photoelectron spectroscopy, and quantum chemical study of the cyclopropylic derivatives. PubMed: Neoadjuvant immunotherapy enhances radiosensitivity through natural killer cell activation. PubMed: Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. PubMed: Diversity synthesis of N-substituted 2-amino-1,6-naphthyridine derivatives under microwave irradiation. PubMed: C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite. PubMed: Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. PubMed: Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors. PubMed: Conformational preferences and basicities of monofluorinated cyclopropyl amines in comparison to cyclopropylamine and 2-fluoroethylamine. PubMed: Synthesis of highly functionalized pyrrolidines via a selective iodide-mediated ring expansion of methylenecyclopropyl amides. PubMed: Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor. PubMed: Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines. PubMed: Electrochemical mass spectrometric studies on 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine. PubMed: In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity. PubMed: Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia. PubMed: Long-range electron and hole transport through DNA with tethered cyclometalated iridium(III) complexes. PubMed: Mechanisms of trovafloxacin hepatotoxicity: studies of a model cyclopropylamine-containing system. PubMed: Synthesis and characterization of iridium(III) cyclometalated complexes with oligonucleotides: insights into redox reactions with DNA. PubMed: Charge separation in a ruthenium-quencher conjugate bound to DNA. PubMed: Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. PubMed: The Kulinkovich reaction in the synthesis of constrained n,n-dialkyl neurotransmitter analogues. PubMed: trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. PubMed: CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo. PubMed: Asymmetric synthesis of cyclopropylamines starting from N-sulfinyl alpha-chloro ketimines. PubMed: Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists. PubMed: EPR studies of amine radical cations. Part 2. Thermal and photo-induced rearrangements of propargylamine and allylamine radical cations in low-temperature freon matrices. PubMed: Synthesis of beta-lactams by Ag+-induced ring expansion of 1-hydroxycyclopropylamines: a theoretical analysis. PubMed: Reassessment of the structural composition of the alkenone distributions in natural environments using an improved method for double bond location based on GC-MS analysis of cyclopropylimines. PubMed: Electron paramagnetic resonance study of the mononuclear Al species formed in the reaction of Al atoms and cyclopropylamine at 77 k in an adamantane matrix. PubMed: Cytochrome P450-catalyzed oxidation of N-benzyl-N-cyclopropylamine generates both cyclopropanone hydrate and 3-hydroxypropionaldehyde via hydrogen abstraction, not single electron transfer. PubMed: Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. PubMed: First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. PubMed: Sequence dependence of charge transport through DNA domains. PubMed: Pressure-induced polymorphism in cyclopropylamine. PubMed: Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines. PubMed: Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes. PubMed: Fluorinated phenylcyclopropylamines. Part 4: effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines. PubMed: Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. PubMed: Synthesis and properties of gem-(difluorocyclopropyl)amine derivatives of bicyclo[n.1.0]alkanes. PubMed: Fluorinated phenylcyclopropylamines as inhibitors of monoamine oxidases. PubMed: Stereochemistry of cyclopropane formation involving group IV organometallic complexes. PubMed: Preliminary evidence of the role of hydrogen peroxide in the degradation of benzo[a]pyrene by a non-white rot fungus Fusarium solani. PubMed: Molecular orbital calculations of ring opening of the isoelectronic cyclopropylcarbinyl radical, cyclopropoxy radical, and cyclopropylaminium radical cation series of radical clocks. PubMed: Early upregulation of kinin B1 receptors in retinal microvessels of the streptozotocin-diabetic rat. PubMed: Theoretical study of the mechanism of the formation of 3-unsubstituted 4,4-disubstituted beta-lactams by silver-induced ring expansion of alkoxycyclopropylamines: a new synthetic route to 4-alkoxycarbonyl-4-alkyl-2-azetidinones. PubMed: Stereocontrolled synthesis of 3-(trans-2-aminocyclopropyl)alanine, a key component of belactosin A. PubMed: Cyclopropane structural units from homoaldol adducts. PubMed: Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine. PubMed: Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. PubMed: Inter-subunit cross-linking of methylamine dehydrogenase by cyclopropylamine requires residue alphaPhe55. PubMed: Radical cation-mediated annulation. Stereoselective construction of bicyclo[5.3.0]decan-3-ones by aerobic oxidation of cyclopropylamines. PubMed: Detection of aminium ion intermediates: N-cyclopropyl versus N-carboxymethyl groups as reporters. PubMed: Effect of mobile phase amine additives on enantioselectivity for phenylalanine analogs. PubMed: N-dealkylation of an N-cyclopropylamine by horseradish peroxidase. Fate of the cyclopropyl group. PubMed: Enzymatic N-dealkylation of an N-cyclopropylamine: an unusual fate for the cyclopropyl group. PubMed: Cytotoxicity of two novel cisplatin analogues, (CPA)2Pt[DOLYM] and (DACH)Pt[DOLYM], to human cancer cells in vitro. PubMed: Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine. PubMed: Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives. PubMed: A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet. PubMed: High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models. PubMed: Enantiomeric Synthesis of L-(or 1'R,2'S)-Carbocyclic Cyclopropyl Nucleosides. PubMed: Model Studies of TTQ-Containing Amine Dehydrogenases. PubMed: Novel 19-(cyclopropylamino)-androst-4-en-3,17-dione: a mechanism-based inhibitor of aromatase. PubMed: Mechanisms of the biphasic effects of peroxides on the retinal vasculature of newborn and adult pigs. PubMed: Mechanistic studies on the monoamine oxidase B catalyzed oxidation of 1,4-disubstituted tetrahydropyridines. PubMed: In vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerations. PubMed: Synthesis, structure, and antitumor activity of 1,3-dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes. PubMed: Reaction of lysyl oxidase with trans-2-phenylcyclopropylamine. PubMed: Inhibition and activation of porcine squalene epoxidase. PubMed: Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. PubMed: Synthesis of [carbonyl-14C]sparfloxacin. PubMed: Inhibition by cyclopropylamine of the quinoprotein methylamine dehydrogenase is mechanism-based and causes covalent cross-linking of alpha and beta subunits. PubMed: Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. PubMed: Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. PubMed: Overview of the present state of MAO inhibitors. PubMed: Microscale syntheses of anti-tumour platinum compounds labelled with 191Pt. PubMed: In vivo distribution studies of radioactively labelled platinum complexes; cis-dichlorodiammine platinum(II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum(IV), cis-dichloro-bis-cyclopropylamine platinum(II), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) in patients with malignant disease, using a gamma camera. PubMed: Effect of alpha-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamine. PubMed: Bacterial degradation of N-cyclopropylmelamine. The steps to ring cleavage. PubMed: Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogues of hallucinogenic phenethylamines: lack of LSD-like biological activity. PubMed: Mutagenic properties of N-cyclopropyl and N-allyl-N-nitroso compounds. Studies on the nature of alkylating species. PubMed: N-[2-(o-iodophenoxy)ethyl]cyclopropylamine hydrochloride (LY121768), a potent and selective irreversible inhibitor of type A monoamine oxidase. PubMed: A comparative study of the distribution in the male rat of platinum-labelled cis-dichlorodiammine platinum (II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (I), and cis-dichloro-bis-cyclopropylamine platinum (II). PubMed: Isomeric cyclopropyl ring-methylated homologues of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, an hallucinogen analogue. PubMed: Blood clearance of three radioactively labelled platinum complexes: cis-dichlorodiammine platinum II, cis, trans-dichlorodihydroxy-bis-(isopropylamine) platinum IV, and cis-dichloro-bis-cyclopropylamine platinum II, in patients with malignant disease. PubMed: Elevation of epinephrine concentration in rat brain by LY51641, a selective inhibitor of type A monoamine oxidase. PubMed: Effect of 2-(p-chlorophenyl)cyclopropylamine on 5-hydroxyindole concentration and monoamine oxidase activity in rat brain. PubMed: Pyridoxal 5'-phosphate levels in brain after treatments which impair cerebral glucose metabolism. PubMed: Analysis of the cardiac stimulant properties of (3,4-dihydroxyphenyl)-cyclopropylamine (ASL-7003) and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (A6,7DTN). PubMed: Conformational analogues of dopamine. Synthesis and pharmacological activity of (E)- and (Z)-2-(3,4-dihydroxyphenyl)cyclopropylamine hydrochlorides. PubMed: Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analogue. PubMed: Irritable aggression and open field behavior in rats given 2-phenylcyclopropylamines. PubMed: Selective in vivo inhibition of monoamine oxidase in rat tissues by N-[2-(O-chlorophenoxy)-ethyl]-cyclopropylamine. PubMed: (+/-)(E)-2-(3,4-Dihydroxyphenyl)cyclopropylamine hydrochloride (ASL-7003): a rigid analogue of dopamine. PubMed: Inhibition of monoamine oxidase by N-phenacyl-cyclopropylamine. PubMed: Effects of three monoamine oxidase inhibitors on ethanol preference in mice. PubMed: 2-(4-imidazolyl)cyclopropylamine. PubMed: Kinetic studies and effects in vivo of a new monoamine oxidase inhibitor, N-[2-(o-chlorophenoxy)-ethyl]-cyclopropylamine. PubMed: A preliminary evaluation of trans-d1-2-phenyl-cyclopropylamine hydrochloride in the ambulatory treatment of depression.