cytochalasin C
7(S),18-dihydroxy-16(S),18(R)-dimethyl-10-phenyl(11)cytochalasa-5,13(E),19(E)-triene-1,17-dione 21(R)-acetate
Identification
| Name | cytochalasin C |
| CAS Number | 22144-76-9 |
| EINECS | 244-803-6 |
| FDA UNII | Search |
| Molecular Formula | C30 H37 N O6 |
| Molecular Weight | 507.62709000 |
| MDL Number | MFCD00066080 |
| Beilstein | 1613194 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 714.32 °C. @ 760.00 mm Hg (est) |
| Flash Point | 726.00 °F. TCC ( 385.80 °C. ) (est) |
| logP (o/w) | 3.250 (est) |
| Soluble in | water, 0.2403 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD > 100 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cytochalasin C usage levels up to | not for fragrance use. |
| Recommendation for cytochalasin C flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1H-
cycloundec(d)isoindole-1,11(2H)-dione, 3-benzyl-3,3a,6,6a,9,10,12,15-octahydro-6,12,15-trihydroxy-4,5,10,12-tetramehtyl-, 15-acetate
7(S),18-
dihydroxy-16(S),18(R)-dimethyl-10-phenyl(11)cytochalasa-5,13(E),19(E)-triene-1,17-dione 21(R)-acetate
PubMed:
[Secondary metabolites of mangrove endophytic fungus BL321 in the South China Sea].
PubMed:
TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation.
PubMed:
In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism.
PubMed:
[Morphological and functional changes of tissue receptors of an organ plexus under the effect of blockers of cytoskeleton assembly].
PubMed:
Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts.
PubMed:
Evidence for LFA-1/ICAM-1 dependent stimulation of protein tyrosine phosphorylation in human B lymphoid cell lines during homotypic adhesion.
PubMed:
Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts.
PubMed:
Phenotype modulation in primary cultures of rat aortic smooth muscle cells. Effects of drugs that interfere with the functions of the vacuolar system and the cytoskeleton.
PubMed:
Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery.
PubMed:
Inhibitory effect of cytochalasins on the motility of rat epididymal spermatozoa in vitro.
PubMed:
The ultrastructural changes of S-100 protein localization during lipolysis in adipocytes. An immunoelectron-microscopic study.
PubMed:
Effect of cytochalasins on surfactant release from alveolar type II cells.
PubMed:
Superoxide generation by neonatal and adult rabbit alveolar macrophages.
PubMed:
Functional studies on B cell hybridomas with B cell surface antigens. IV. Direct effects of cytochalasin B on differentiation.
PubMed:
Structure-activity correlations of cytochalasins. Novel halogenated and related cytochalasin C and D derivatives.
PubMed:
Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro.
PubMed:
Stimulation of actin ATPase activity by cytochalasins provides evidence for a new species of monomeric actin.