cytochalasin D
lygosporin A
Identification
| Name | cytochalasin D |
| CAS Number | 22144-77-0 |
| EINECS | 244-804-1 |
| FDA UNII | SY9F0FZ3TO |
| Molecular Formula | C30 H37 N O6 |
| Molecular Weight | 507.62709000 |
| MDL Number | MFCD00077706 |
| Beilstein | 1632828 |
Regulatory
Physical Properties
| Appearance | white fluffy powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 712.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 724.00 °F. TCC ( 384.50 °C. ) (est) |
| logP (o/w) | 2.640 (est) |
| Soluble in | water, 0.8627 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 2 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: EXCITEMENT']
Safety in Use
| Category | natural substances and extractives |
BOC Sciences
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Potential Uses
Natural Occurrence
Synonyms
cytochalasind
lygosporin A
zygosporin A
PubMed:
Transport of Egg White ACE-Inhibitory Peptide, Gln-Ile-Gly-Leu-Phe, in Human Intestinal Caco-2 Cell Monolayers with Cytoprotective Effect.
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Transport of IRW, an ovotransferrin-derived antihypertensive peptide, in human intestinal epithelial Caco-2 cells.
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Transepithelial transport of theasinensins through Caco-2 cell monolayers and their absorption in Sprague-Dawley rats after oral administration.
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[Relation analysis between intracellular distribution of nanomateriarls, ROS generation and DNA damage].
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Interactions between Clostridium perfringens spores and Raw 264.7 macrophages.
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Internalization of Escherichia coli o157:h7 by bovine rectal epithelial cells.
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Campylobacter fetus translocation across Caco-2 cell monolayers.
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The Nf-actin gene is an important factor for food-cup formation and cytotoxicity of pathogenic Naegleria fowleri.
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Cellular differentiation in moss protonemata: a morphological and experimental study.
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A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum.
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Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro.
PubMed:
Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum.
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Fine particles that adsorb lipopolysaccharide via bridging calcium cations may mimic bacterial pathogenicity towards cells.
PubMed:
Specific effects of denaturation, hydrolysis and exposure to Lactococcus lactis on bovine beta-lactoglobulin transepithelial transport, antigenicity and allergenicity.
PubMed:
Adhesion and ingestion activities of fish phagocytes induced by bacterium Aeromonas salmonicida can be distinguished and directly measured from highly diluted whole blood of fish.
PubMed:
Campylobacter fetus adheres to and enters INT 407 cells.
PubMed:
MYO1, a novel, unconventional myosin gene affects endocytosis and macronuclear elongation in Tetrahymena thermophila.
PubMed:
Use of green fluorescent protein (GFP) to study the invasion pathways of Edwardsiella tarda in in vivo and in vitro fish models.
PubMed:
A semiautomated fluorescence-based cell-to-cell fusion assay for gp120-gp41 and CD4 expressing cells.
PubMed:
Effect of capsianoside, a diterpene glycoside, on tight-junctional permeability.
PubMed:
[An inhibitory analysis of the role of the enterocyte cytoskeleton in the absorption of food substances in the small intestine].
PubMed:
Down-regulation of surface FcRI and decrease in antibody-dependent cellular cytotoxicity of cultured monocytes. Reversal by monensin or cytochalasin-D.
PubMed:
Toxic fungal metabolites in food.
PubMed:
Teratogenicity of cytochalasin D in the mouse.