cytochalasin H
(11)cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18S,19E,21R)-
Identification
| Name | cytochalasin H |
| CAS Number | 53760-19-3 |
| FDA UNII | Search |
| Molecular Formula | C30 H39 N O5 |
| Molecular Weight | 493.64383000 |
| MDL Number | MFCD00010539 |
| Beilstein | 1632647 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 676.49 °C. @ 760.00 mm Hg (est) |
| Flash Point | 685.00 °F. TCC ( 362.90 °C. ) (est) |
| logP (o/w) | 4.758 (est) |
| Soluble in | water, 0.018 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-chicken LD50 12500 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cytochalasin H usage levels up to | not for fragrance use. |
| Recommendation for cytochalasin H flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(11)
cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18S,19E,21R)-
kodocytochalasin-1
paspalin
PubMed:
Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis.
PubMed:
Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thorns.
PubMed:
Polar auxin transport in relation to long-distance transport of nutrients in the Charales.
PubMed:
A novel phytotoxic nonenolide from Phomopsis sp. HCCB03520.
PubMed:
Ep-oxy-cytochalasin H methanol solvate.
PubMed:
Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa.
PubMed:
Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines.
PubMed:
1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08).
PubMed:
Changes in secondary metabolism during stromatal ontogeny of Hypoxylon fragiforme.
PubMed:
Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganisation, on platelet function.
PubMed:
New botrydial sesquiterpenoids from Hymenoscyphus epiphyllus.
PubMed:
Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases.
PubMed:
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure.
PubMed:
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. I. The producing organism and its fermentation.
PubMed:
Effects of cytochalasin H on chick embryo explants cultured in vitro.
PubMed:
Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells.
PubMed:
Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro.
PubMed:
Inhibitory effect of cytochalasin H on cell reaggregation of the fresh water sponge, Ephydatia meyeni Carter.
PubMed:
The actions of various cytochalasins on mouse adrenal tumor cells in relation to trophic stimulation of steroidogenesis.
PubMed:
Ultrastructural changes in the embryonic cells of the frog Microhyla ornata after cytochalasin H treatment.
PubMed:
Effects of cytochalasin H on human lymphocyte cultures.
PubMed:
Effects of cytochalasin H on the morphogenetic movements of the embryos of Microhyla ornata.
PubMed:
Effects of cytochalasin H on the embryonic endodermal cells of Microhyla ornata.
PubMed:
Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1.
PubMed:
Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp.