cytochalasin J
(3S,3aR,4S,6aR,7E,13E,15R)-3-benzyl-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-1-one
Identification
| Name | cytochalasin J |
| CAS Number | 56144-22-0 |
| FDA UNII | Search |
| Molecular Formula | C28 H37 N O4 |
| Molecular Weight | 451.60669000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 679.51 °C. @ 760.00 mm Hg (est) |
| Flash Point | 689.00 °F. TCC ( 364.80 °C. ) (est) |
| logP (o/w) | 4.628 (est) |
| Soluble in | water, 0.2406 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-mouse LD50 5 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cytochalasin J usage levels up to | not for fragrance use. |
| Recommendation for cytochalasin J flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(3S,3aR,4S,6aR,7E,13E,15R)-3-
benzyl-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-1-one
kodocytochalasin 2
paspalin P
PubMed:
Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest.
PubMed:
Both actin and myosin inhibitors affect spindle architecture in PtK1 cells: does an actomyosin system contribute to mitotic spindle forces by regulating attachment and movements of chromosomes in mammalian cells?
PubMed:
Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa.
PubMed:
Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells.
PubMed:
Localization of myosin II to chromosome arms and spindle fibers in PtK1 cells: a possible role for an actomyosin system in mitosis.
PubMed:
Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents.
PubMed:
Redistribution of motor proteins by Cytochalasin J treatment.
PubMed:
The effect of cytochalasin J on kinetochore structure in PtK1 cells is mitotic cycle dependent.
PubMed:
Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells.
PubMed:
Cytochalasin J affects chromosome congression and spindle microtubule organization in PtK1 cells.