dextro-aspartic acid
D-aminosuccinic acid
Identification
| Name | dextro-aspartic acid |
| IUPAC | (2R)-2-aminobutanedioic acid |
| CAS Number | 1783-96-6 |
| EINECS | 217-234-6 |
| FDA UNII | 4SR0Q8YD1X |
| Molecular Formula | C4 H7 N O4 |
| Molecular Weight | 133.10359000 |
| MDL Number | MFCD00063081 |
| Nikkaji Number | J9.205C |
| Beilstein | 1723529 |
| XlogP3 | -2.80 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 264.12 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.003000 mmHg @ 25.00 °C. (est) |
| Flash Point | 236.00 °F. TCC ( 113.50 °C. ) (est) |
| logP (o/w) | -1.075 (est) |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for dextro-aspartic acid usage levels up to | not for fragrance use. |
| Recommendation for dextro-aspartic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acide D-aspartique
(R)-2-
amino-succinic acid
(2R)-2-
aminobutanedioic acid
(R)-2-
aminobutanedioic acid
(2R)-2-
aminosuccinic acid
(R)-2-
aminosuccinic acid
D-
aminosuccinic acid
D-
asparaginsaeure
D-
aspartatic acid
(-)-
aspartic acid
(R)-
aspartic acid
D-
aspartic acid
D-(-)-
aspartic acid
aspartic acid D-
aspartic acid, D-
D-
asparticacid
PubMed:
Evaluation of enantiomeric purity of magnesium-l-aspartate dihydrate.
J-Stage:
Enzymatic Assay for D-Aspartic Acid Using D-Aspartate Oxidase and Oxaloacetate Decarboxylase
PubMed:
Repeated ketamine administration alters N-methyl-d-aspartic acid receptor subunit gene expression: Implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans.
PubMed:
IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids.
PubMed:
Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice.
PubMed:
Spinal muscular atrophy: an update on therapeutic progress.
PubMed:
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
PubMed:
Differential effects of serotonin-specific and excitotoxic lesions of OFC on conditioned reinforcer devaluation and extinction in rats.
PubMed:
Racemization of the aspartic acid residue of amyloid-β peptide by a radical reaction.
PubMed:
Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine.
PubMed:
Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake.
PubMed:
Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies.
PubMed:
The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys.
PubMed:
Visible wavelength spectrophotometric assays of L-aspartate and D-aspartate using hyperthermophilic enzyme systems.
PubMed:
The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats.
PubMed:
The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.
PubMed:
Magnesium for treatment-resistant depression: a review and hypothesis.
PubMed:
Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors.
PubMed:
Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmitters.
PubMed:
Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
PubMed:
D-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats.
PubMed:
Enantiomer separation of imidazo-quinazoline-dione derivatives on quinine carbamate-based chiral stationary phase in normal phase mode.
PubMed:
Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study.
PubMed:
Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior.
PubMed:
Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice.
PubMed:
Relationships among mercury, selenium, and neurochemical parameters in common loons (Gavia immer) and bald eagles (Haliaeetus leucocephalus).
PubMed:
Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus.
PubMed:
The influence of manufacture on the free D-amino acid content of Cheddar cheese.
PubMed:
D-amino acid formation in sterilized alkali-treated olives.
PubMed:
Paenidase, a novel D-aspartyl endopeptidase from Paenibacillus sp. B38: purification and substrate specificity.
PubMed:
A new method of age estimation based on the changes in human non-collagenous proteins from dentin.
PubMed:
Origins of lateral hypothalamic afferents associated with N-methyl-d-aspartic acid-elicited eating studied using reverse microdialysis of NMDA and Fluorogold.
PubMed:
First evidence on induced topological changes in supercoiled DNA by an aluminium D-aspartate complex.
PubMed:
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
PubMed:
Regional differences in feeding and other behaviors elicited by N-methyl-D-aspartic acid in the rodent hypothalamus: a reverse microdialysis mapping study.
PubMed:
Reverse microdialysis of N-methyl-D-aspartic acid into the lateral hypothalamus of rats: effects on feeding and other behaviors.
PubMed:
Physiological studies on umami taste.
PubMed:
Glutamatergic control of food intake in pigeons: effects of central injections of glutamate, NMDA, and AMPA receptor agonists and antagonists.
PubMed:
Racemization kinetics of aspartic acid in fish material under different conditions of moisture, pH, and oxygen pressure.
PubMed:
Changes of amino acid composition and lysinoalanine formation in alkali-pickled duck eggs.
PubMed:
Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541.
PubMed:
Effect of NMDA lesion of the medial preoptic neurons on sleep and other functions.
PubMed:
Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell.
PubMed:
Modulation of the discriminative stimulus and rate-altering effects of cocaine by competitive and noncompetitive N-methyl-D-aspartate antagonists.
PubMed:
Changes in glutamate receptors, c-fos mRNA expression and activator protein-1 (AP-1) DNA binding activity in the brain of phenobarbital-dependent and -withdrawn rats.
PubMed:
Evaluation of D-amino acid levels in rat by gas chromatography-selected ion monitoring mass spectrometry: no evidence for subacute toxicity of orally fed D-proline and D-aspartic acid.
PubMed:
Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat.
PubMed:
NMDA-induced lesions of the nucleus accumbens or the ventral pallidum increase the rewarding efficacy of food to deprived rats.
PubMed:
Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons.
PubMed:
LY226936 administered orally and centrally to obese Zucker rats suppresses food intake and body weight gain.
PubMed:
The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating.
PubMed:
Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats.
PubMed:
Central mechanisms subserving the impaired growth hormone secretion induced by persistent blockade of NMDA receptors in immature male rats.
PubMed:
Excitotoxic lesions of the paraventricular hypothalamus: metabolic and cardiac effects.
PubMed:
Delay of puberty and impairment of growth in female rats given a non competitive antagonist of NMDA receptors.
PubMed:
Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats.
PubMed:
Aggravation by morphine and D-aspartic acid of pyelonephritis induced by i.v. inoculation of Staphylococcus aureus in rats.
PubMed:
Some N-acyl-D-amino acid derivatives having antibotulinal properties.
PubMed:
The inhibition by morphine and D-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism by L-aspartic acid.
PubMed:
Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity.
PubMed:
Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100 degrees C.
PubMed:
Antagonistic effect of L-aspartic acid on decrease in body weight, and food and fluid intake, and naloxone reversible rectal temperature depression caused by D-aspartic acid.