dextro-aspartic acid

D-aminosuccinic acid

CAS: 1783-96-6 C4 H7 N O4 MW: 133.10359000

Identification

Namedextro-aspartic acid
IUPAC(2R)-2-aminobutanedioic acid
CAS Number1783-96-6
EINECS217-234-6
FDA UNII4SR0Q8YD1X
Molecular FormulaC4 H7 N O4
Molecular Weight133.10359000
MDL NumberMFCD00063081
Nikkaji NumberJ9.205C
Beilstein1723529
XlogP3-2.80 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 264.12 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.003000 mmHg @ 25.00 °C. (est)
Flash Point 236.00 °F. TCC ( 113.50 °C. ) (est)
logP (o/w) -1.075 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for dextro-aspartic acid usage levels up tonot for fragrance use.
Recommendation for dextro-aspartic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

acide D-aspartique (R)-2- amino-succinic acid (2R)-2- aminobutanedioic acid (R)-2- aminobutanedioic acid (2R)-2- aminosuccinic acid (R)-2- aminosuccinic acid D- aminosuccinic acid D- asparaginsaeure D- aspartatic acid (-)- aspartic acid (R)- aspartic acid D- aspartic acid D-(-)- aspartic acid aspartic acid D- aspartic acid, D- D- asparticacid PubMed: Evaluation of enantiomeric purity of magnesium-l-aspartate dihydrate. J-Stage: Enzymatic Assay for D-Aspartic Acid Using D-Aspartate Oxidase and Oxaloacetate Decarboxylase PubMed: Repeated ketamine administration alters N-methyl-d-aspartic acid receptor subunit gene expression: Implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans. PubMed: IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. PubMed: Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice. PubMed: Spinal muscular atrophy: an update on therapeutic progress. PubMed: The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. PubMed: Differential effects of serotonin-specific and excitotoxic lesions of OFC on conditioned reinforcer devaluation and extinction in rats. PubMed: Racemization of the aspartic acid residue of amyloid-β peptide by a radical reaction. PubMed: Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine. PubMed: Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake. PubMed: Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies. PubMed: The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys. PubMed: Visible wavelength spectrophotometric assays of L-aspartate and D-aspartate using hyperthermophilic enzyme systems. PubMed: The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats. PubMed: The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. PubMed: Magnesium for treatment-resistant depression: a review and hypothesis. PubMed: Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors. PubMed: Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmitters. PubMed: Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. PubMed: D-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats. PubMed: Enantiomer separation of imidazo-quinazoline-dione derivatives on quinine carbamate-based chiral stationary phase in normal phase mode. PubMed: Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study. PubMed: Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior. PubMed: Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice. PubMed: Relationships among mercury, selenium, and neurochemical parameters in common loons (Gavia immer) and bald eagles (Haliaeetus leucocephalus). PubMed: Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus. PubMed: The influence of manufacture on the free D-amino acid content of Cheddar cheese. PubMed: D-amino acid formation in sterilized alkali-treated olives. PubMed: Paenidase, a novel D-aspartyl endopeptidase from Paenibacillus sp. B38: purification and substrate specificity. PubMed: A new method of age estimation based on the changes in human non-collagenous proteins from dentin. PubMed: Origins of lateral hypothalamic afferents associated with N-methyl-d-aspartic acid-elicited eating studied using reverse microdialysis of NMDA and Fluorogold. PubMed: First evidence on induced topological changes in supercoiled DNA by an aluminium D-aspartate complex. PubMed: Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. PubMed: Regional differences in feeding and other behaviors elicited by N-methyl-D-aspartic acid in the rodent hypothalamus: a reverse microdialysis mapping study. PubMed: Reverse microdialysis of N-methyl-D-aspartic acid into the lateral hypothalamus of rats: effects on feeding and other behaviors. PubMed: Physiological studies on umami taste. PubMed: Glutamatergic control of food intake in pigeons: effects of central injections of glutamate, NMDA, and AMPA receptor agonists and antagonists. PubMed: Racemization kinetics of aspartic acid in fish material under different conditions of moisture, pH, and oxygen pressure. PubMed: Changes of amino acid composition and lysinoalanine formation in alkali-pickled duck eggs. PubMed: Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541. PubMed: Effect of NMDA lesion of the medial preoptic neurons on sleep and other functions. PubMed: Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell. PubMed: Modulation of the discriminative stimulus and rate-altering effects of cocaine by competitive and noncompetitive N-methyl-D-aspartate antagonists. PubMed: Changes in glutamate receptors, c-fos mRNA expression and activator protein-1 (AP-1) DNA binding activity in the brain of phenobarbital-dependent and -withdrawn rats. PubMed: Evaluation of D-amino acid levels in rat by gas chromatography-selected ion monitoring mass spectrometry: no evidence for subacute toxicity of orally fed D-proline and D-aspartic acid. PubMed: Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat. PubMed: NMDA-induced lesions of the nucleus accumbens or the ventral pallidum increase the rewarding efficacy of food to deprived rats. PubMed: Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons. PubMed: LY226936 administered orally and centrally to obese Zucker rats suppresses food intake and body weight gain. PubMed: The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating. PubMed: Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. PubMed: Central mechanisms subserving the impaired growth hormone secretion induced by persistent blockade of NMDA receptors in immature male rats. PubMed: Excitotoxic lesions of the paraventricular hypothalamus: metabolic and cardiac effects. PubMed: Delay of puberty and impairment of growth in female rats given a non competitive antagonist of NMDA receptors. PubMed: Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats. PubMed: Aggravation by morphine and D-aspartic acid of pyelonephritis induced by i.v. inoculation of Staphylococcus aureus in rats. PubMed: Some N-acyl-D-amino acid derivatives having antibotulinal properties. PubMed: The inhibition by morphine and D-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism by L-aspartic acid. PubMed: Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity. PubMed: Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100 degrees C. PubMed: Antagonistic effect of L-aspartic acid on decrease in body weight, and food and fluid intake, and naloxone reversible rectal temperature depression caused by D-aspartic acid.