dequalinium chloride

dequadin chloride

CAS: 522-51-0 C30 H40 Cl2 N4 MW: 527.58080000

Identification

Namedequalinium chloride
CAS Number522-51-0
EINECS208-330-9
FDA UNIIXYS8INN1I6
Molecular FormulaC30 H40 Cl2 N4
Molecular Weight527.58080000
MDL NumberMFCD00063502

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 326.00 °C. @ 760.00 mm Hg
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 5000 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LD50 18300 ug/kg
Dermal Toxicitysubcutaneous-mouse LD50 70 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for dequalinium chloride usage levels up tonot for fragrance use.
Recommendation for dequalinium chloride flavor usage levels up tonot for flavor use.

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Potential Uses

antimicrobial agents oral care agents

Natural Occurrence

not found in nature

Synonyms

1-[10-(4- amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine;dichloride 1-[10-(4- amino-2-methylquinolyl)decyl]-2-methyl-4-quinolylamine, chloride, chloride 1,10- decamethylene-bis(4-aminoquinaldinium chloride) decamethylenebis(4-aminoquinaldinium chloride) 1,1'- decamethylenebis(4-aminoquinaldinium chloride) 1,1'- decamethylenebis(4-aminoquinaldinium) dichloride 1,1'- decamethylenebis(4-aminoquinaldinium) dichloride hydrate 1,1'- decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride 1,1'-(1,10- decanediyl)bis(4-amino-2-methylquinolinium) dichloride dequadin chloride quinaldinium, 1,1'-decamethylenebis(4-amino)-, dichloride quinolinium, 1,1'-(1,10-decanediyl)bis(4-amino-2-methyl-, dichloride (9CI) quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2) quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride PubMed: Effects of flavone on the contractile activity of the circular smooth muscle of the rabbit middle colon in vitro. PubMed: Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. PubMed: XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells. PubMed: Treatment of bacterial vaginosis: what we have and what we miss. PubMed: Susceptibility testing of Atopobium vaginae for dequalinium chloride. PubMed: A comparison of dequalinium chloride vaginal tablets (Fluomizin®) and clindamycin vaginal cream in the treatment of bacterial vaginosis: a single-blind, randomized clinical trial of efficacy and safety. PubMed: Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions? PubMed: Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening. PubMed: New method for the quantification of dequalinium cations in pharmaceutical samples by absorption and fluorescence diode array thin-layer chromatography. PubMed: Determination for micro amounts of nucleic acids by a resonance light scattering technique with dequalinium chloride. PubMed: Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel. PubMed: Determination of antibacterial quaternary ammonium compound in lozenges and human serum by resonance light scattering technique. PubMed: Type IVB piliated Salmonella typhi enhance IL-6 and NF-kappaB production in human monocytic THP-1 cells through activation of protein kinase C. PubMed: Mitochondrial leader sequence--plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. PubMed: Flow injection spectrofluorimetric study of the supramolecular interaction between beta-cyclodextrin and dequalinium chloride and its analytical application. PubMed: Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors. PubMed: The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations. PubMed: Local treatment of vaginal infections of varying etiology with dequalinium chloride or povidone iodine. A randomised, double-blind, active-controlled, multicentric clinical study. PubMed: Antimicrobial activity of dequalinium chloride against leading germs of vaginal infections. PubMed: Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line. PubMed: Occupational allergic contact dermatitis from alkylammonium amidobenzoate. PubMed: Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. PubMed: Mitochondrial membrane potential regulation is independent of c-fos expression. PubMed: Capillary electrophoresis and liquid chromatography in the analysis of some quaternary ammonium salts used in lozenges as antibacterial agents. PubMed: KATP channel blocking actions of quaternary ions play no role in their antiproliferative action on mouse leukaemia and rat vascular smooth muscle cells in vitro. PubMed: Determination of antibacterial quaternary ammonium compounds in lozenges by capillary electrophoresis. PubMed: Determination of the quaternary ammonium compounds dequalinium and cetylpyridinium chlorides in candy-based lozenges by high-performance liquid chromatography. PubMed: Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumor cell lines: targets for therapy. PubMed: Anticarcinoma activity of a novel drug, 3-ethyl-3'-methyl-thiatelluracarbocyanine iodide (Te), a tellurium-containing cyanine targeted at mitochondria. PubMed: A nuclear magnetic resonance method for the determination of the purity of commercial dequalinium chloride. PubMed: AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity. PubMed: Effect of recombinant human tumor-necrosis-factor-alpha and dequalinium chloride on human ovarian-cancer cell-lines in-vitro. PubMed: Failure to enhance the in vivo killing of human ovarian carcinoma by sequential treatment with dequalinium chloride and tumor necrosis factor. PubMed: Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. PubMed: Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity. PubMed: Characterization of a human ovarian carcinoma cell line: UCI 101. PubMed: Mitochondria as a target for combination cancer-chemotherapy. PubMed: [Effects of dequalinium chloride and sanguinarine on the ultrastructure of early supragingival plaque]. PubMed: [The efficacy of dequalinium chloride/benzalkonium chloride as well as medicinal plants on the gingiva]. PubMed: Inhibition of bovine heart mitochondrial and Paracoccus denitrificans NADH----ubiquinone reductase by dequalinium chloride and three structurally related quinolinium compounds. PubMed: [Antimicrobial characteristics of a tincture of dequalinium chloride]. PubMed: Inhibition of rat colon tumor isograft growth with dequalinium chloride. PubMed: [The foretell method of the observation of crystal growth of dequalinium chloride in short time in oil in water type ointments]. PubMed: [Maltyl gargling solution. Report on an experiment using a new, ready-to-use antiseptic (dequalinium chloride) for the mouth and throat]. PubMed: [Disorders of the nose, mouth and throat. Therapeutic experiences with a dequalinium chloride solution for gargling in a clinical comparative study]. PubMed: [Doubleblind test of dequalinium chloride in 60 children with oral moniliasis]. PubMed: [Treatment of tonsillitis with dequalinium chloride]. PubMed: Some physiological alteration associated with pleiotropic cross resistance and collateral sensitivity in Saccharomyces cerevisiae. PubMed: Modification and inheritance of pleiotropic cross resistance and collateral sensitivity in Saccharomyces cerevisiae. PubMed: Microvascular response to local application of dequalinium chloride. A vital microscopical study of hamster's cheek pouch and a microangiographic study of rabbit's ear. PubMed: [Effect of dequalinium chloride troche in oral region (author's transl)]. PubMed: Development of strength in dequalinium chloride-treated skin incisions in rat. PubMed: [Dequalinium chloride in bucco-pharyngeal diseases]. PubMed: [Industrial medical experience with dequalinium chloride in treatment of inflammatory diseases of the mouth cavity and pharynx]. PubMed: The local anesthetic action of dequalinium chloride. PubMed: The treatment of black hairy tongue with dequalinium chloride; a preliminary report.