dichloroacetic acid

dichloroethanoic acid

CAS: 79-43-6 C2 H2 Cl2 O2 MW: 128.94034000

Identification

Namedichloroacetic acid
IUPAC2,2-dichloroacetic acid
CAS Number79-43-6
EINECS201-207-0
FDA UNII9LSH52S3LQ
Molecular FormulaC2 H2 Cl2 O2
Molecular Weight128.94034000
MDL NumberMFCD00004223
Nikkaji NumberJ2.834G
Beilstein1098596
XlogP30.90 (est)

Regulatory

Physical Properties

Appearance colorless crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.56300 @ 25.00 °C.
Refractive Index 1.46630 @ 20.00 °C.
Melting Point 13.50 °C. @ 760.00 mm Hg
Boiling Point 194.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.196000 mmHg @ 25.00 °C. (est)
Vapor Density 4.45 ( Air = 1 )
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 0.920
Soluble in water, 1.00E+06 mg/L @ 20 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 2820 mg/kg
Dermal Toxicityskin-rabbit LD50 510 uL/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for dichloroacetic acid usage levels up tonot for fragrance use.
Recommendation for dichloroacetic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

acetic acid, 2,2-dichloro- acetic acid, dichloro- bichloracetic acid bichloroacetic acid DCAA dichloracetic acid dichlorethanoic acid dichloro acetic acid dichloro-acetic acid 2,2- dichloroacetic acid dichloroaceticacid dichloroethanoic acid urner's liquid PubMed: Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster. PubMed: Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats. PubMed: Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. PubMed: Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice. PubMed: Analysis of in vivo mutation data can inform cancer risk assessment. PubMed: Trials and tribulations. PubMed: Treatment for mitochondrial disorders. PubMed: Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry. PubMed: Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats. PubMed: Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate. PubMed: Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes. PubMed: Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. PubMed: Subacute toxicity of trichloroacetic acid in male and female rats. PubMed: Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats. PubMed: Dichloroacetate treatment of ischemic cerebral lactic acidosis in the fed rat. PubMed: Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation. Possible mechanisms and a regulatory role for thyroid hormone. PubMed: Effect of chloroacetic acids on the kidneys. PubMed: Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. A regulatory role for pyruvate dehydrogenase in liver and extrahepatic tissues. PubMed: Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate. PubMed: Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition.