dichloroacetic acid
dichloroethanoic acid
Identification
| Name | dichloroacetic acid |
| IUPAC | 2,2-dichloroacetic acid |
| CAS Number | 79-43-6 |
| EINECS | 201-207-0 |
| FDA UNII | 9LSH52S3LQ |
| Molecular Formula | C2 H2 Cl2 O2 |
| Molecular Weight | 128.94034000 |
| MDL Number | MFCD00004223 |
| Nikkaji Number | J2.834G |
| Beilstein | 1098596 |
| XlogP3 | 0.90 (est) |
Regulatory
Physical Properties
| Appearance | colorless crystalline solid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.56300 @ 25.00 °C. |
| Refractive Index | 1.46630 @ 20.00 °C. |
| Melting Point | 13.50 °C. @ 760.00 mm Hg |
| Boiling Point | 194.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.196000 mmHg @ 25.00 °C. (est) |
| Vapor Density | 4.45 ( Air = 1 ) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | 0.920 |
| Soluble in | water, 1.00E+06 mg/L @ 20 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 2820 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 510 uL/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for dichloroacetic acid usage levels up to | not for fragrance use. |
| Recommendation for dichloroacetic acid flavor usage levels up to | not for flavor use. |
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Potential Uses
Natural Occurrence
Synonyms
acetic acid, 2,2-dichloro-
acetic acid, dichloro-
bichloracetic acid
bichloroacetic acid
DCAA
dichloracetic acid
dichlorethanoic acid
dichloro acetic acid
dichloro-acetic acid
2,2-
dichloroacetic acid
dichloroaceticacid
dichloroethanoic acid
urner's liquid
PubMed:
Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.
PubMed:
Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats.
PubMed:
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
PubMed:
Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice.
PubMed:
Analysis of in vivo mutation data can inform cancer risk assessment.
PubMed:
Trials and tribulations.
PubMed:
Treatment for mitochondrial disorders.
PubMed:
Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry.
PubMed:
Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats.
PubMed:
Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.
PubMed:
Effect of dexamethasone on gluconeogenesis, pyruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes.
PubMed:
Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics.
PubMed:
Subacute toxicity of trichloroacetic acid in male and female rats.
PubMed:
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats.
PubMed:
Dichloroacetate treatment of ischemic cerebral lactic acidosis in the fed rat.
PubMed:
Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation. Possible mechanisms and a regulatory role for thyroid hormone.
PubMed:
Effect of chloroacetic acids on the kidneys.
PubMed:
Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. A regulatory role for pyruvate dehydrogenase in liver and extrahepatic tissues.
PubMed:
Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate.
PubMed:
Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition.