benzyl isothiocyanate

benzene, (isothiocyanatomethyl)- benzyl isothio cyanate benzyl mustard benzyl mustard oil benzylisothiocyanate phenylmethanisothiocyanate phenylmethyl isothiocyanate iso thiocyanatomethyl-benzene (iso thiocyanatomethyl) benzene (iso thiocyanatomethyl)benzene (iso thiocyanatomethyl)benzol iso thiocyanatomethylbenzene a-iso thiocyanatotoluene alpha-iso thiocyanatotoluene iso thiocyanic acid benzyl ester iso thiocyanic acid, benzyl ester toluene, a-isothiocyanato- tromacaps tromalyt urogran Info: miscellaneous nitrogen derivatives PubMed: Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells. J-Stage: a-Tocopherol Sensitizes Human Leukemia HL-60 Cells to Apoptosis Induced by Benzyl Isothiocyanate PubMed: Chemo-predictive assay for targeting cancer stem-like cells in patients affected by brain tumors. PubMed: Purification of Active Myrosinase from Plants by Aqueous Two-Phase Counter-Current Chromatography. PubMed: Glycyl endopeptidase from papaya latex: partial purification and use for production of fish gelatin hydrolysate. PubMed: Efficient 1-Step Radiolabeling of Monoclonal Antibodies to High Specific Activity with 225Ac for α-Particle Radioimmunotherapy of Cancer. PubMed: Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. PubMed: Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity-resistant BALB/c mice. PubMed: Antiinflammatory activity of glucomoringin isothiocyanate in a mouse model of experimental autoimmune encephalomyelitis. PubMed: Review: an exposition of medicinal preponderance of Moringa oleifera (Lank.). PubMed: Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy. PubMed: In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates. PubMed: Benzyl isothiocyanate inhibits HNSCC cell migration and invasion, and sensitizes HNSCC cells to cisplatin. PubMed: Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina. PubMed: A chemical approach for the reduction of beauvericin in a solution model and in food systems. PubMed: Antibacterial activity of glucomoringin bioactivated with myrosinase against two important pathogens affecting the health of long-term patients in hospitals. PubMed: Odour-active compounds in papaya fruit cv. Red Maradol. PubMed: Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni. PubMed: Oral administration of benzyl-isothiocyanate inhibits in vivo growth of subcutaneous xenograft tumors of human malignant melanoma A375.S2 cells. PubMed: Determination of benzyl isothiocyanate metabolites in human plasma and urine by LC-ESI-MS/MS after ingestion of nasturtium (Tropaeolum majus L.). PubMed: Benzyl isothiocyanate: double trouble for breast cancer cells. PubMed: Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation. PubMed: Inhibitory effect of benzyl isothiocyanate on proliferation in vitro of human glioma cells. PubMed: Dietary chemopreventative benzyl isothiocyanate inhibits breast cancer stem cells in vitro and in vivo. PubMed: High-performance liquid chromatographic enantioseparation of (RS)-bupropion using isothiocyanate-based chiral derivatizing reagents. PubMed: Downregulation of Mcl-1 through inhibition of translation contributes to benzyl isothiocyanate-induced cell cycle arrest and apoptosis in human leukemia cells. PubMed: Antimicrobial isothiocyanates from the seeds of Moringa oleifera Lam. PubMed: Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. PubMed: Study of the chemical reduction of the fumonisins toxicity using allyl, benzyl and phenyl isothiocyanate in model solution and in food products. PubMed: Stability of benzylic-type isothiocyanates in hydrodistillation-mimicking conditions. PubMed: Benzyl isothiocyanate induces protective autophagy in human prostate cancer cells via inhibition of mTOR signaling. PubMed: Apoptosis induced by benzyl isothiocyanate in gefitinib-resistant lung cancer cells is associated with Akt/MAPK pathways and generation of reactive oxygen species. PubMed: Erucin and benzyl isothiocyanate suppress growth of late stage primary human ovarian carcinoma cells and telomerase activity in vitro. PubMed: Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle. PubMed: Antimicrobial activities of isothiocyanates against Campylobacter jejuni isolates. PubMed: Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells. PubMed: Benzyl isothiocyanate disturbs lipid metabolism in rats in a way independent of its thyroid impact following in vivo long-term treatment and in vitro adipocytes studies. PubMed: Identifying and characterizing binding sites on the irreversible inhibition of human glutathione S-transferase P1-1 by S-thiocarbamoylation. PubMed: Proteomic analysis of covalent modifications of tubulins by isothiocyanates. PubMed: Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells. PubMed: Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration. PubMed: Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. PubMed: Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death. PubMed: α-Tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate. PubMed: Content determination of benzyl glucosinolate and anti-cancer activity of its hydrolysis product in Carica papaya L. PubMed: Cytotoxicity of benzyl isothiocyanate in normal renal proximal tubular cells and its modulation by glutathione. PubMed: Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition. PubMed: Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways. PubMed: Contact and fumigant toxicity of Armoracia rusticana essential oil, allyl isothiocyanate and related compounds to Dermatophagoides farinae. PubMed: Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PubMed: Nanoemulsions of cancer chemopreventive agent benzyl isothiocyanate display enhanced solubility, dissolution, and permeability. PubMed: Benzyl isothiocyanate inhibits basal and hepatocyte growth factor-stimulated migration of breast cancer cells. PubMed: Validated high-performance liquid chromatographic enantioseparation of selenomethionine using isothiocyanate based chiral derivatizing reagents. PubMed: Varied response of Spodoptera littoralis against Arabidopsis thaliana with metabolically engineered glucosinolate profiles. PubMed: Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis. PubMed: Benzyl isothiocyanate, a major component from the roots of Salvadora persica is highly active against Gram-negative bacteria. PubMed: Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. PubMed: Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity. PubMed: MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer. PubMed: Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. PubMed: Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates. PubMed: Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates. PubMed: Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. PubMed: Characteristics of papaya seed oils obtained by extrusion-expelling processes. PubMed: Evaluation of antibacterial activity of 3-butenyl, 4-pentenyl, 2-phenylethyl, and benzyl isothiocyanate in Brassica vegetables. PubMed: Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. PubMed: Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene in C57BL/6J mice. PubMed: Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells. PubMed: Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. PubMed: Stimulation of phagocytosis by sulforaphane. PubMed: The roles of AIF and Endo G in the apoptotic effects of benzyl isothiocyanate on DU 145 human prostate cancer cells via the mitochondrial signaling pathway. PubMed: Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. PubMed: Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. PubMed: Effectiveness of different solid-phase microextraction fibres for differentiation of selected Madeira island fruits based on their volatile metabolite profile--identification of novel compounds. PubMed: Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. PubMed: Characterization and antimicrobial activity of 4-(β-D-glucopyranosyl-1→4-α-L-rhamnopyranosyloxy)-benzyl thiocarboxamide; a novel bioactive compound from Moringa oleifera seed extract. PubMed: The toxic effects of benzyl glucosinolate and its hydrolysis product, the biofumigant benzyl isothiocyanate, to Folsomia fimetaria. PubMed: Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates. PubMed: Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. PubMed: BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis. PubMed: Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells. PubMed: Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells. PubMed: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways. PubMed: p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression. PubMed: Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. PubMed: Preclinical evaluation of monoclonal antibody 14C5 for targeting pancreatic cancer. PubMed: Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate. PubMed: Trypanocidal and antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala, and their main individual constituents. PubMed: Immunochemical detection of food-derived isothiocyanate as a lysine conjugate. PubMed: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PubMed: New biomarkers for monitoring the levels of isothiocyanates in humans. PubMed: [Antimicrobial efficacy of benzyl isothiocyanate]. PubMed: Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smoke. PubMed: Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate. PubMed: Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria. PubMed: Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin. PubMed: Differing mechanisms of simple nitrile formation on glucosinolate degradation in Lepidium sativum and Nasturtium officinale seeds. PubMed: A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. PubMed: Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells. PubMed: Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery. PubMed: Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation. PubMed: Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. PubMed: Re: The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. PubMed: Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation therapy. PubMed: Diverse chemicals including aryl hydrocarbon receptor ligands modulate transcriptional activity of the 3'immunoglobulin heavy chain regulatory region. PubMed: Phytochemical induction of cell cycle arrest by glutathione oxidation and reversal by N-acetylcysteine in human colon carcinoma cells. PubMed: Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. PubMed: The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract. PubMed: Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo. PubMed: Degradation and sorption of 2-propenyl and benzyl isothiocyanate in soil. PubMed: Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L. PubMed: The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. PubMed: Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells. PubMed: Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells. PubMed: (-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes. PubMed: Acaricidal constituents isolated from Sinapis alba L. seeds and structure-activity relationships. PubMed: Benzylglucosinolate, benzylisothiocyanate, and myrosinase activity in papaya fruit during development and ripening. PubMed: Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation. PubMed: Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. PubMed: ATP depletion alters the mode of cell death induced by benzyl isothiocyanate. PubMed: Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells. PubMed: Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents. PubMed: Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells. PubMed: Formation and degradation kinetics of the biofumigant benzyl isothiocyanate in soil. PubMed: Comments regarding: Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro Kalkunte S, Swamy N, Dizon DS, Brard L. J Exp Ther Oncol.5(4):287-300, 2006. PubMed: Papaya seed represents a rich source of biologically active isothiocyanate. PubMed: Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. PubMed: Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells. PubMed: Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells. PubMed: p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1. PubMed: Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro. PubMed: Cell death induction by isothiocyanates and their underlying molecular mechanisms. PubMed: Haplotype-environment interactions that regulate the human glutathione S-transferase P1 promoter. PubMed: Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity. PubMed: Molecular cloning of AbGst1 encoding a glutathione transferase differentially expressed during exposure of Alternaria brassicicola to isothiocyanates. PubMed: Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest. PubMed: Characterization of two Arabidopsis thaliana glutathione S-transferases. PubMed: The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. PubMed: Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells. PubMed: Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. PubMed: Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction. PubMed: Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers. PubMed: (89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab. PubMed: Modulation of jejunal contractions by extract of Carica papaya L. seeds. PubMed: The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates. PubMed: The identification of 1,3-oxazolidine-2-thiones and 1,3-thiazolidine-2-thiones from the reaction of glucose with benzyl isothiocyanate. PubMed: Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration. PubMed: Benzyl isothiocyanate modifies expression of the G2/M arrest-related genes. PubMed: A novel function of benzyl isothiocyanate in vascular smooth muscle cells: the role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9. PubMed: Dietary isothiocyanates inhibit Caco-2 cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation. PubMed: Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities. PubMed: Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21. PubMed: Glutathione S-transferase Pi has at least three distinguishable xenobiotic substrate sites close to its glutathione-binding site. PubMed: Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. PubMed: Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours. PubMed: Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control. PubMed: Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells. PubMed: Pregnancy outcomes following pre- and post-implantation exposure of Sprague-Dawley rats to benzyl isothiocyanate. PubMed: A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. PubMed: Effect of benzyl isothiocyanate on spontaneous and induced force of rat uterine contraction. PubMed: In vitro digestion of sinigrin and glucotropaeolin by single strains of Bifidobacterium and identification of the digestive products. PubMed: Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis. PubMed: Tocolytic and toxic activity of papaya seed extract on isolated rat uterus. PubMed: Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation. PubMed: Influence of plant and bacterial myrosinase activity on the metabolic fate of glucosinolates in gnotobiotic rats. PubMed: Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma. PubMed: Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats. PubMed: Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. PubMed: Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages. PubMed: Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. PubMed: Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay. PubMed: Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine. PubMed: Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. PubMed: Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. PubMed: Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. PubMed: Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction. PubMed: Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages. PubMed: Palladium(0)-catalyzed enantioselective O,S-rearrangement of racemic O-allylic thiocarbamates: a new entry to enantioenriched allylic sulfur compounds. PubMed: Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats. PubMed: Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. PubMed: Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. PubMed: 4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish). PubMed: Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. PubMed: Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. PubMed: Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A. PubMed: Benzyl isothiocyanate is the chief or sole anthelmintic in papaya seed extracts. PubMed: Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors. PubMed: Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. PubMed: Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables. PubMed: Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1. PubMed: Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse. PubMed: A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates. PubMed: Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure. PubMed: Mechanism of oxidative DNA damage induced by carcinogenic allyl isothiocyanate. PubMed: Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. PubMed: Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates. PubMed: Glutathione redox potential in response to differentiation and enzyme inducers. PubMed: Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer. PubMed: Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent. PubMed: Dietary compounds that induce cancer preventive phase 2 enzymes activate apoptosis at comparable doses in HT29 colon carcinoma cells. PubMed: Inactivation of cytochrome P450 2E1 by benzyl isothiocyanate. PubMed: Antimicrobial components of some cruciferae plants (Diplotaxis harra Forsk. and Erucaria microcarpa Boiss.) PubMed: An antitumor promoter from Moringa oleifera Lam. PubMed: Temporal effects of the detoxification enzyme inducer, benzyl isothiocyanate: activation of c-Jun N-terminal kinase prior to the transcription factors AP-1 and NFkappaB. PubMed: Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. PubMed: Modulation by phytochemicals of cytochrome P450-linked enzyme activity. PubMed: Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate. PubMed: Reactions of a glucosinolate breakdown product (benzyl isothiocyanate) with myoglobin. PubMed: Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats. PubMed: Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1. PubMed: The environment of 5S rRNA in the ribosome: cross-links to the GTPase-associated area of 23S rRNA. PubMed: Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. PubMed: Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: results of a phase I clinical trial. PubMed: Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke. PubMed: Effects of isothiocyanates on cytochrome P-450 1A1 and 1A2 activity and on the mutagenicity of heterocyclic amines. PubMed: Enzyme induction and comparative oxidative desulfuration of isothiocyanates to isocyanates. PubMed: Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates. PubMed: Lack of inhibitory effect of benzyl isothiocyanate on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats. PubMed: Influence of benzylisothiocyanate and 13-cis-retinoic acid on micronucleus formation induced by benzo[a]pyrene. PubMed: Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat. PubMed: Chemoprevention of lung cancer by isothiocyanates. PubMed: In vitro and in vivo antitumor activity of benzyl isothiocyanate: a natural product from Tropaeolum majus. PubMed: Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis and DNA methylation by isothiocyanates. PubMed: Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanates. PubMed: Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29. PubMed: Some aspects of reactions of benzyl isothiocyanate with bovine sarcoplasmic proteins. PubMed: Chemoprevention by isothiocyanates. PubMed: Cytotoxic and clastogenic effects of benzyl isothiocyanate towards cultured mammalian cells. PubMed: Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. PubMed: Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. PubMed: Inhibitory effects of benzyl thiocyanate and benzyl isothiocyanate on methylazoxymethanol acetate-induced intestinal carcinogenesis in rats. PubMed: Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity. PubMed: Effects of isothiocyanates on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene by hamster and rat liver microsomes. PubMed: Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models. PubMed: Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats. PubMed: Radioimmunolocalization of metastatic breast carcinoma using indium-111-methyl benzyl DTPA BrE-3 monoclonal antibody: phase I study. PubMed: The clastogenic effects of isothiocyanates. PubMed: Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. PubMed: Modulation of carcinogen-induced polyoma DNA-replication by organoselenium and organosulfur chemopreventive agents. PubMed: Modifying effects of benzyl isothiocyanate and benzyl thiocyanate on DNA synthesis in primary cultures of rat hepatocytes. PubMed: Reversed-phase high-performance liquid chromatographic separation of the stereoisomers of labetalol via derivatization with chiral and non-chiral isothiocyanate reagents. PubMed: In vitro stability of EDTA and DTPA immunoconjugates of monoclonal antibody 2G3 labeled with indium-111. PubMed: Structure-function relationships in indium-111 radioimmunoconjugates. PubMed: Subacute oral toxicity study of benzyl isothiocyanate in rats. PubMed: Hepatobiliary delivery of polyaminopolycarboxylate chelates: synthesis and characterization of a cholic acid conjugate of EDTA and biodistribution and imaging studies with its indium-111 chelate. PubMed: Characterization of antibody-chelator conjugates: determination of chelator content by terbium fluorescence titration. PubMed: Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates. PubMed: Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates. PubMed: Inhibition of carcinogenesis by minor anutrient constituents of the diet. PubMed: Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice. PubMed: Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate. PubMed: Inhibition of carcinogenesis by naturally-occurring and synthetic compounds. PubMed: Ethylene-like activity of isocyanides. PubMed: Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates. PubMed: Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. PubMed: Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3',5'-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates. PubMed: Reversed-phase liquid chromatographic separation of enantiomeric and diastereomeric bases related to chloramphenicol and thiamphenicol. PubMed: Characterization of benzyl isothiocyanate and phenyl acetonitrile from papayas by mass spectrometry. PubMed: Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species. PubMed: Studies on the metabolism and excretion of benzyl isothiocyanate in man. PubMed: Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene. PubMed: Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. PubMed: Cytomorphological changes in liver cells exposed to allyl and benzyl isothiocyanate and their cysteine and glutathione conjugates. PubMed: Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate. PubMed: Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice. PubMed: Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs. PubMed: Investigations into the possible regulation of negative gravitropic curvature in intact Avena sativa plants and in isolated stem segments by ethylene and gibberellins. PubMed: Antiasthmatic effects of onion extracts--detection of benzyl- and other isothiocyanates (mustard oils) as antiasthmatic compounds of plant origin. PubMed: Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues. PubMed: Quantitation of a bioactive metabolite in undisturbed rhizosphere-Benzyl isothiocyanate fromCarica papaya L. PubMed: Postharvest Variation in Cell Wall-Degrading Enzymes of Papaya (Carica papaya L.) during Fruit Ripening. PubMed: The metabolism of benzyl isothiocyanate and its cysteine conjugate in guinea-pigs and rabbits. PubMed: Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactones, and benzyl isothiocyanate. PubMed: Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. PubMed: Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure. PubMed: Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of Benzo[a]pyrene-induced neoplasia of the forestomach. PubMed: Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. PubMed: The metabolism of benzyl isothiocyanate and its cysteine conjugate. PubMed: Inhibition of papain by isothiocyanates. PubMed: Inhibition of ethylene evolution in papaya pulp tissue by benzyl isothiocyanate. PubMed: Bacterial degradation of benzyl isothiocyanate. PubMed: Control of encephalitis in laboratory monkeys by benzyl isothiocyanate.