dimethoxymethane
methylal
Identification
| Name | dimethoxymethane |
| CAS Number | 109-87-5 |
| EINECS | 203-714-2 |
| FDA UNII | 7H1M4G2NUE |
| Molecular Formula | C3 H8 O2 |
| Molecular Weight | 76.09516000 |
| MDL Number | MFCD00008495 |
| Nikkaji Number | J3.250F |
| Beilstein | 1697025 |
| CoE Number | 10031 |
| XlogP3 | 0.20 (est) |
Regulatory
| DG SANTE Food Flavourings | 06.074 dimethoxymethane |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Water Content | ~0.1% |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.85500 to 0.86200 @ 25.00 °C. |
| Pounds per Gallon - (est). | 7.114 to 7.173 |
| Refractive Index | 1.35000 to 1.35600 @ 20.00 °C. |
| Melting Point | -105.00 °C. @ 760.00 mm Hg |
| Boiling Point | 42.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 398.000000 mmHg @ 25.00 °C. |
| Flash Point | 1.00 °F. TCC ( -17.22 °C. ) |
| Soluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | solvents |
Organoleptic Properties
| Odor Description | chloroform |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-rat LD50 [sex: F] 7950 mg/kg |
| Dermal Toxicity | skin-rabbit LD > 16 mL/kg |
| Inhalation Toxicity | inhalation-mouse LC50 57000 mg/m3/7H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | solvents |
| Recommendation for dimethoxymethane usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.012 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 1600 (μg/person/day) |
| Threshold of Concern | 1800 (μg/person/day) |
| Structure Class | I |
| Dairy products, excluding products of category 02.0 (01.0) | 3.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | 2.00000 |
| Edible ices, including sherbet and sorbet (03.0) | 3.00000 |
| Processed fruit (04.1) | 2.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 4.00000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 2.00000 |
| Bakery wares (07.0) | 5.00000 |
| Meat and meat products, including poultry and game (08.0) | 1.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | 1.00000 |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 2.00000 |
| Foodstuffs intended for particular nutritional uses (13.0) | 3.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 2.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | 4.00000 |
| Ready-to-eat savouries (15.0) | 5.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 2.00000 |
ECSA Chemicals
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Potential Uses
Natural Occurrence
Synonyms
dimethoxymethane
1,1-
dimethoxymethane
dimethyl formal
formaldehyde dimethyl acetal
formaldehyde dimethyl ketal
formaldehyde dimethylacetal
methane, dimethoxy-
bis(
methoxy)methane
methoxymethyl methyl ether
methylal
methylene dimethyl ether
methylene glycol dimethylether
bis(
methyloxy)methane
PubMed:
Biofiltration of high formaldehyde loads with ozone additions in long-term operation.
PubMed:
Highly stable CO2/N2 and CO2/CH4 selectivity in hyper-cross-linked heterocyclic porous polymers.
PubMed:
Clostridium geopurificans strain MJ1 sp. nov., a strictly anaerobic bacterium that grows via fermentation and reduces the cyclic nitramine explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).
PubMed:
[Study on occupational exposure limit of dimethoxymethane in workplace air].
PubMed:
[Progress in research on toxicity of dimethoxymethane and its occupational exposure limit].
PubMed:
[Determination of dimethoxymethane in air of workplace by gas chromatography].
PubMed:
DFT investigations for the reaction mechanism of dimethyl carbonate synthesis on Pd(II)/β zeolites.
PubMed:
[Determination of methylal in the air of workplace with solvent desorption by gas chromatography].
PubMed:
Dimethoxymethane-hydrogen chloride interaction: gas phase versus low-temperature behavior studied using matrix isolation infrared and density functional theory methods.
PubMed:
How the generalized anomeric effect influences the conformational preference.
PubMed:
Intermolecular acetaldehyde and dimethoxymethane formation mechanisms via ethenol and methoxymethylene precursors in reactions of atomic carbon with methanol: a computational study.
PubMed:
Mechanistic investigations on dimethyl carbonate formation by oxidative carbonylation of methanol over a CuY zeolite: an operando SSITKA/DRIFTS/MS study.
PubMed:
A Ferrier-type allylic rearrangement of 3'-deoxy-3',4'-didehydronucleosides mediated by DMF dimethyl acetal: direct access to 4'-alkoxy-2',3'-didehydro-2',3'-dideoxynucleosides.
PubMed:
Selective oxidation of methanol to dimethoxymethane over bifunctional VO(x)/TS-1 catalysts.
PubMed:
An easily accessible Re-based catalyst for the selective conversion of methanol: evidence for an unprecedented active site structure through combined operando techniques.
PubMed:
Influence of the solvent on the charge distribution of anomeric compounds.
PubMed:
A systematic study on the activation of simple polyethers by MoCl5 and WCl6.
PubMed:
Ligand close packing, molecular compactness, the methyl tilt, molecular conformations, and a new model for the anomeric effect.
PubMed:
Vapor-phase carbonylation of dimethoxymethane over H-Faujasite.
PubMed:
Preparation and characterization of mesoporous VO(x)-TiO2 complex oxides for the selective oxidation of methanol to dimethoxymethane.
PubMed:
Molecular dynamics simulation of interactions between a sodium dodecyl sulfate micelle and a poly(ethylene oxide) polymer.
PubMed:
Amorphous oxide as a novel efficient catalyst for direct selective oxidation of methanol to dimethoxymethane.
PubMed:
Imaging momentum orbital densities of conformationally versatile molecules: a benchmark theoretical study of the molecular and electronic structures of dimethoxymethane.
PubMed:
Selective oxidation of methanol to dimethoxymethane under mild conditions over V2O5/TiO2 with enhanced surface acidity.
PubMed:
Noncovalent interactions and internal dynamics in dimethoxymethane-water.
PubMed:
Atoms in molecules interpretation of the anomeric effect in the O--C--O unit.
PubMed:
Selective oxidation of methanol and ethanol on supported ruthenium oxide clusters at low temperatures.
PubMed:
Ultraviolet photolysis of CH2I2 in methanol: O-H insertion and HI elimination reactions to form a dimethoxymethane product.
PubMed:
The external-anomeric torsional effect.
PubMed:
Electrochemical oxidation of methanol using dppm-bridged Ru/Pd, Ru/Pt and Ru/Au catalysts.
PubMed:
Diastereo- and enantioselective dearomatization of rhenium-bound naphthalenes.
PubMed:
Matrix isolation infrared and ab initio study of the conformations of 2,2-dimethoxypropane.
PubMed:
Tandem 1,4-addition reactions with benzene and alkylated benzenes promoted by pentaammineosmium(II).
PubMed:
Volatile metabolites from microorganisms grown on humid building materials and synthetic media.
PubMed:
Conformations of dimethoxymethane: matrix isolation infrared and ab initio studies.
PubMed:
Metastable ion study of organosilicon compounds. Part XIII: dimethoxydimethylsilane, (CH(3))(2)Si(OCH(3))(2), and dimethoxymethylsilane, CH(3)SiH(OCH(3))(2).
PubMed:
Porphyrins with exocyclic rings. 16. Synthesis and spectroscopic characterization of fluoranthoporphyrins, a new class of highly conjugated porphyrin chromophores.
PubMed:
Unimolecular metastable decompositions of gem-dimethoxyalkanes (RR'C(OCH(3))(2)) upon electron impact. I. Dimethoxymethane and 1, 1-dimethoxyethane
PubMed:
[Gas chromatographic determination of methylal in atmospheric air].
PubMed:
[Methylal: its metabolism and hygienic standardization in the air of work areas].
PubMed:
Determination of phosphatidylglycerol in amniotic fluid by a simple one-dimensional thin-layer chromatography method.
PubMed:
Convenient synthesis of N-alkoxymethylbarbituric acids and N-alkoxymethylhydantoins.
PubMed:
A chemical assay method for the determination of aflatoxin residues in animal tissues.
PubMed:
The toxicity of methylal.
PubMed:
Anesthesia with methylal in dogs, mice and rats.