dimethyl fumarate
2-butenedioic acid (E)-, dimethyl ester
Identification
| Name | dimethyl fumarate |
| CAS Number | 624-49-7 |
| EINECS | 210-849-0 |
| FDA UNII | FO2303MNI2 |
| Molecular Formula | C6 H8 O4 |
| Molecular Weight | 144.12656000 |
| MDL Number | MFCD00064438 |
| Nikkaji Number | J45.019G |
| Beilstein | 0774590 |
| XlogP3 | 0.70 (est) |
Regulatory
| FDA Mainterm (IAUFC) | 624-49-7 ; METHYL FUMARATE |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1.877e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for dimethyl fumarate usage levels up to | not for fragrance use. |
| Recommendation for dimethyl fumarate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
trans-
butene dioic acid dimethyl ester
2-
butenedioic acid (E)-, dimethyl ester
dimethyl (E)-but-2-enedioate
dimethyl trans-butene dioate
dimethylfumarate
fumaric acid dimethyl ester
fumaric acid, dimethyl ester
PubMed:
Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis.
PubMed:
Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients.
PubMed:
Update on disease-modifying therapies for multiple sclerosis.
PubMed:
(1) H qNMR Quantification of Annonaceous Acetogenins in Crude Extracts of Annona muricata L. Fruit Pulp.
PubMed:
Liver injury associated with dimethyl fumarate in multiple sclerosis patients.
PubMed:
Efficacy and tolerability of dimethyl fumarate in White-, African- and Hispanic- Americans with multiple sclerosis.
PubMed:
Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats.
PubMed:
Teriflunomide for multiple sclerosis.
PubMed:
Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.
PubMed:
Gastrointestinal Tolerability of Delayed-Release Dimethyl Fumarate in a Multicenter, Open-Label Study of Patients with Relapsing Forms of Multiple Sclerosis (MANAGE).
PubMed:
Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist.
PubMed:
Consensus Management of Gastrointestinal Events Associated with Delayed-Release Dimethyl Fumarate: A Delphi Study.
PubMed:
Novel Agents for Relapsing Forms of Multiple Sclerosis.
PubMed:
Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis.
PubMed:
[Determination of dimethyl fumarate in bakery food by d-SPE-HPLC-PDA].
PubMed:
Dimethyl fumarate for multiple sclerosis.
PubMed:
Managing flushing and gastrointestinal events associated with delayed-release dimethyl fumarate: Experiences of an international panel.
PubMed:
New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis.
PubMed:
Oral disease-modifying therapies for relapsing-remitting multiple sclerosis.
PubMed:
Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP.
PubMed:
Multiple sclerosis: a primary care perspective.
PubMed:
Dimethyl fumarate protection against collagen II degradation.
PubMed:
Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate.
PubMed:
Pharmacology and clinical efficacy of dimethyl fumarate (BG-12) for treatment of relapsing-remitting multiple sclerosis.
PubMed:
Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways.
PubMed:
An update on new and emerging therapies for relapsing-remitting multiple sclerosis.
PubMed:
Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies.
PubMed:
Risk assessment of dimethylfumarate residues in dwellings following contamination by treated furniture.
PubMed:
Multiple sclerosis: Five new things.
PubMed:
The top 10 drug trends right now.
PubMed:
Drugs: An injection of hope.
PubMed:
Globalisation and allergy.
PubMed:
Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis.
PubMed:
Combination of dacarbazine and dimethylfumarate efficiently reduces melanoma lymph node metastasis.
PubMed:
[Effects of chemical agents on the prevention of fungal contamination during household wheat storage in Cixian county].
PubMed:
Inhibition of Escherichia coli by dimethyl fumarate.
PubMed:
Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state?
PubMed:
Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.