dimethyl fumarate

2-butenedioic acid (E)-, dimethyl ester

CAS: 624-49-7 C6 H8 O4 MW: 144.12656000

Identification

Namedimethyl fumarate
CAS Number624-49-7
EINECS210-849-0
FDA UNIIFO2303MNI2
Molecular FormulaC6 H8 O4
Molecular Weight144.12656000
MDL NumberMFCD00064438
Nikkaji NumberJ45.019G
Beilstein0774590
XlogP30.70 (est)

Regulatory

FDA Mainterm (IAUFC)624-49-7 ; METHYL FUMARATE

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1.877e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for dimethyl fumarate usage levels up tonot for fragrance use.
Recommendation for dimethyl fumarate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

trans- butene dioic acid dimethyl ester 2- butenedioic acid (E)-, dimethyl ester dimethyl (E)-but-2-enedioate dimethyl trans-butene dioate dimethylfumarate fumaric acid dimethyl ester fumaric acid, dimethyl ester PubMed: Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis. PubMed: Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients. PubMed: Update on disease-modifying therapies for multiple sclerosis. PubMed: (1) H qNMR Quantification of Annonaceous Acetogenins in Crude Extracts of Annona muricata L. Fruit Pulp. PubMed: Liver injury associated with dimethyl fumarate in multiple sclerosis patients. PubMed: Efficacy and tolerability of dimethyl fumarate in White-, African- and Hispanic- Americans with multiple sclerosis. PubMed: Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats. PubMed: Teriflunomide for multiple sclerosis. PubMed: Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. PubMed: Gastrointestinal Tolerability of Delayed-Release Dimethyl Fumarate in a Multicenter, Open-Label Study of Patients with Relapsing Forms of Multiple Sclerosis (MANAGE). PubMed: Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist. PubMed: Consensus Management of Gastrointestinal Events Associated with Delayed-Release Dimethyl Fumarate: A Delphi Study. PubMed: Novel Agents for Relapsing Forms of Multiple Sclerosis. PubMed: Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis. PubMed: [Determination of dimethyl fumarate in bakery food by d-SPE-HPLC-PDA]. PubMed: Dimethyl fumarate for multiple sclerosis. PubMed: Managing flushing and gastrointestinal events associated with delayed-release dimethyl fumarate: Experiences of an international panel. PubMed: New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis. PubMed: Oral disease-modifying therapies for relapsing-remitting multiple sclerosis. PubMed: Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP. PubMed: Multiple sclerosis: a primary care perspective. PubMed: Dimethyl fumarate protection against collagen II degradation. PubMed: Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate. PubMed: Pharmacology and clinical efficacy of dimethyl fumarate (BG-12) for treatment of relapsing-remitting multiple sclerosis. PubMed: Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways. PubMed: An update on new and emerging therapies for relapsing-remitting multiple sclerosis. PubMed: Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies. PubMed: Risk assessment of dimethylfumarate residues in dwellings following contamination by treated furniture. PubMed: Multiple sclerosis: Five new things. PubMed: The top 10 drug trends right now. PubMed: Drugs: An injection of hope. PubMed: Globalisation and allergy. PubMed: Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis. PubMed: Combination of dacarbazine and dimethylfumarate efficiently reduces melanoma lymph node metastasis. PubMed: [Effects of chemical agents on the prevention of fungal contamination during household wheat storage in Cixian county]. PubMed: Inhibition of Escherichia coli by dimethyl fumarate. PubMed: Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state? PubMed: Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.