diphenhydramine HCL

2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride

CAS: 147-24-0 C17 H21 N O.Cl H

Identification

Namediphenhydramine HCL
IUPAC2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
CAS Number147-24-0
EINECS205-687-2
FDA UNIITC2D6JAD40
Molecular FormulaC17 H21 N O.Cl H
MDL NumberMFCD00012479

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 343.70 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000069 mmHg @ 25.00 °C. (est)
Flash Point 215.00 °F. TCC ( 101.50 °C. ) (est)
logP (o/w) 3.662 (est)
Soluble in water, 602.4 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshair conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-child TDLo 12500 ug/kg
Dermal Toxicityskin-child TDLo 60 mg/kg/6H-I
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC\nVASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION\nBEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nLUNGS, THORAX, OR RESPIRATION: DYSPNEA\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD']

Safety in Use

Categorycosmetic agents
Recommendation for diphenhydramine HCL usage levels up tonot for fragrance use.
Recommendation for diphenhydramine HCL flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

actifed sinus nighttime alledryl allergina allergival ambenyl antitussive bagodryl bayer select night time pain relief beldin belix bena-fedrin benacine benadril hydrochloride benadryl bendylate benzantin benzehist O- benzhydryldimethylaminoethanol hydrochloride 2- benzhydryloxy-N,N-dimethyl-ethanamine 2- benzhydryloxy-N,N-dimethylethanamine;hydrochloride 2-( benzhydryloxy)-N,N-dimethylethanamine hydrochloride 2-( benzhydryloxy)-N,N-dimethylethylamine hydrochloride 2-( benzhydryloxy)-N,N-dimethylethylamine, hydrochloride caladryl carphenex cathejell contac day & night allergy sinus night caplets contac day & night cold/flu night caplets dabylen denydryl dibondrin difenhydramine hydrochloride dimedrol a-(2- dimethylaminoethoxy)diphenylmethane hydrochloride b- dimethylaminoethyl benzhydryl ether hydrochloride diphenhydramine hydrochloride diphenhydraminehydrochloride diphenylhydramine hydrochloride 2- diphenylmethoxy-N,N-dimethylethanamine hydrochloride 2- diphenylmethoxy-N,N-dimethylethylamine hydrochloride 2-( diphenylmethoxy)-N,N-dimethylethanamine hydrochloride 2-( diphenylmethoxy)-N,N-dimethylethanaminium chloride [2-( diphenylmethoxy)ethyl]dimethylamine hydrochloride [2-( diphenylmethoxy)ethyl]dimethylamine, chloride N-(2- diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride 2-[( diphenylmethyl)oxy]-N,N-dimethylethanamine hydrochloride dobacen hydrochloride dolestan eldadryl ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1) ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-, hydrochloride felben fenylhist halbmond histacyl midol pm night time formula noctomin paradryl prodryl resmin restamin sedopretten sekundal-D silphen sleep-eze-3 syntedril tylenol allergy sinus night time caplets tylenol cold night time liquid tylenol flu night time gelcaps tylenol flu night time powder tylenol pm tablets/caplets valdrene vicks formula 44 wehydryl ziradryl PubMed: Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions. PubMed: Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis. PubMed: Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration. PubMed: A composite polyelectrolytic matrix for controlled oral drug delivery. PubMed: Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media. PubMed: Prescription writing trends of antihistamines at the university health centre. PubMed: Black ant stings caused by Pachycondyla sennaarensis: a significant health hazard. PubMed: The comparison of diphenhydramine HCl and Nedocromil sodium in prevention of abdominal postoperative adhesion formation in rat models: an experimental study. PubMed: Microwave-assisted solvent extraction of solid matrices and subsequent detection of pharmaceuticals and personal care products (PPCPs) using gas chromatography-mass spectrometry. PubMed: Temperature/Humidity sensitivity of sustained-release formulations containing Kollidon SR. PubMed: A study of the effects of curing and storage conditions on controlled release diphenhydramine HCl pellets coated with Eudragit NE30D. PubMed: Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions in rats. PubMed: Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets. PubMed: Study of crystallization of endogenous surfactant in Eudragit NE30D-free films and its influence on drug-release properties of controlled-release diphenhydramine HCl pellets coated with Eudragit NE30D. PubMed: Childhood serum sickness: a case report. PubMed: Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. PubMed: Effects of formulation variables and post-compression curing on drug release from a new sustained-release matrix material: polyvinylacetate-povidone. PubMed: Indirect atomic absorption determination of atropine, diphenhydramine, tolazoline, and levamisole based on formation of ion-associates with potassium tetraiodometrcurate. PubMed: Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate. PubMed: Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography. PubMed: Prevention and treatment of dichlorvos-induced toxicosis in mice by diphenhydramine. PubMed: [An animal model for screening of antiallergic and antipruritic drugs]. PubMed: Differential illness intrusiveness associated with sleep-promoting medications. PubMed: Inhibition of neutral endopeptidase potentiates compound 48/80-induced constriction of guinea-pig tracheal smooth muscle. PubMed: Comparison of the sedative effectiveness of two pharmacological regimens. PubMed: Mechanism of drug release from an acrylic polymer-wax matrix tablet. PubMed: [4-Aminopyridine-induced licking response and histamine liberation in mice]. PubMed: Phosphoramidon modulates effects of the 5-lipoxygenase inhibition on anaphylactic contraction of the guinea pig trachea. PubMed: Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. PubMed: Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing. PubMed: Spectrophotometric determination of ephedrine HCl, cinchonine HCl, chlorpheniramine maleate, atropine sulphate and diphenhydramine HCl by solvent extraction of reineckate complexes. PubMed: Effect of diphenhydramine on organophosphorus insecticide toxicity in mice. PubMed: Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro: II. Results with 20 chemicals. PubMed: Antihistamines reverse blood-ocular barrier breakdown in experimental diabetes. PubMed: Medical emergencies aboard commercial aircraft. PubMed: Tagamet-induced acute dystonia. PubMed: An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs. PubMed: Superoxide anion generation during airway anaphylaxis. PubMed: Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. PubMed: Supra-additive toxic interaction of nicotine with antihistamines, and enhancement by the proconvulsant pentylenetetrazole. PubMed: The contractile properties of wound granulation tissue. PubMed: The pharmacokinetics of meprobamate following its oral and rectal administration as a series of combinations with diphenhydramine, acetylsalicylic acid, codeine and pentaerythritol tetranitrate. PubMed: Diphenhydramine: kinetics and psychomotor effects in elderly women. PubMed: Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey. PubMed: Stimulant actions of histamine H1 antagonists on operant behavior in the squirrel monkey. PubMed: Effect of anti-parkinsonism drugs on gastric emptying and intestinal transit in the rat. PubMed: Suppression of histamine-induced pruritus by three antihistaminic drugs. PubMed: Teratogenesis studies with diphenhydramine HCl. PubMed: Effect of chlorpromazine, WY 1246 Melleril, diphenhydramine HCl (benadryl) and tyramine on barbital anesthesia. PubMed: Treatment of leg cramps during pregnancy: use of diphenhydramine HCl. PubMed: The effect of diphenhydramine HCL (benadryl HCL) on skeletal muscle. PubMed: The influence of diphenhydramine HCl (benadryl) on apomorphine-induced emesis in dogs.