dextro,laevo-homatropine hydrobromide
homatropine DL- hydrobromide
Identification
| Name | dextro,laevo-homatropine hydrobromide |
| IUPAC | (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide |
| CAS Number | 51-56-9 |
| EINECS | 200-105-3 |
| FDA UNII | BEW7469QZ0 |
| Molecular Formula | C16 H22 Br N O3 |
| Molecular Weight | 356.25994000 |
| MDL Number | MFCD00012676 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 250.00 °C. @ 760.00 mm Hg |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| Soluble in | water, 1.49E+05 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-mouse LD50 107 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for dextro,laevo-homatropine hydrobromide usage levels up to | not for fragrance use. |
| Recommendation for dextro,laevo-homatropine hydrobromide flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide
benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide (1:1)
benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, HBr, endo-(+-)
benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide, endo-(+-)-
homatropine (bromhydrate d')
(+-)-
homatropine bromide
homatropine DL- hydrobromide
(8-
methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
1alphaH,5alphaH-
tropan-3alpha-ol mandelate (ester) hydrobromide
PubMed:
The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults.
PubMed:
Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE.
PubMed:
Interference of mandelic acid with the determination of homatropine hydrobromide by second-order derivative spectroscopy.
PubMed:
Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy.
PubMed:
Determination of homatropine hydrobromide in eye drops by second-order derivative spectroscopy.
PubMed:
[Correction of the symptoms of late substance withdrawal syndrome by intra-conjunctival administration of 5% homatropine solution (preliminary report)].
PubMed:
An evaluation of the effectiveness of intramuscular atropine or homatropine eyedrops in preventing the effects of physostigmine eyedrops on human vision.
PubMed:
Effect of urea on the activity of certain ophthalmic drugs in man.
PubMed:
Memo on medications: atropine sulfate and homatropine hydrobromide: common mydriatic/cycloplegic agents.
PubMed:
Relapsing polychondritis in a Latin American man.
PubMed:
[Photometric determination of homatropine hydrobromide in eyedrops].
PubMed:
[Cycloplegia and residual accommodation (author's transl)].
PubMed:
[Homatropine hydrobromide].
PubMed:
Stability determination of homatropine hydrobromide by direct cerimetric titration.
PubMed:
HOMATROPINE HYDROBROMIDE. EFFECT OF TOPICAL ADMINISTRATION UPON THE INTRAOCULAR PRESSURE AND AQUEOUS FACILITY VALUES OF NORMAL AND CHRONIC SIMPLE GLAUCOMATOUS EYES.
PubMed:
[Use of a 4 per cent solution of homatropine hydrobromide for the determination of refraction in young patients].
PubMed:
Ophthalmic vehicles: the effect of methylcellulose on the penetration of homatropine hydrobromide through the cornea.
PubMed:
Effects of atropine sulfate, methylatropine nitrate (metropine) and homatropine hydrobromide on adult human eyes.