dextro,laevo-norleucine
DL-a-aminocaproic acid
Identification
| Name | dextro,laevo-norleucine |
| IUPAC | 2-aminohexanoic acid |
| CAS Number | 616-06-8 |
| EINECS | 210-462-7 |
| FDA UNII | 5C81BE5GKK |
| Molecular Formula | C6 H13 N O2 |
| Molecular Weight | 131.17501000 |
| MDL Number | MFCD00064422 |
| Nikkaji Number | J1.268H |
| Beilstein | 1721748 |
| XlogP3 | -1.50 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 234.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 204.00 °F. TCC ( 95.30 °C. ) (est) |
| logP (o/w) | 0.920 (est) |
| Soluble in | water, 1.18E+04 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for dextro,laevo-norleucine usage levels up to | not for fragrance use. |
| Recommendation for dextro,laevo-norleucine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2-
aminocaproic acid
DL-a-
aminocaproic acid
(±)-2-
aminohexanoic acid
2-
aminohexanoic acid
(+-)-nor
leucine
D-(-)-nor
leucine
DL-nor
leucine
nor
leucine, D-(-)-
PubMed:
Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAHENU2 mice.
PubMed:
Solid-state phase transitions of DL-aminobutyric acid.
PubMed:
Size-dependent phase stability of a molecular nanocrystal: a proxy for investigating the early stages of crystallization.
PubMed:
Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffraction.
PubMed:
Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy.
PubMed:
Concerted molecular displacements in a thermally-induced solid-state transformation in crystals of DL-norleucine.
PubMed:
Spontaneous resolution of binary copper(II) complexes with racemic dipeptides: crystal structures of glycyl-L-alpha-amino-n-butyrato copper(II) monohydrate, glycyl-D-valinato copper(II) hemihydrate, and glycyl-L-valinato copper(II) hemihydrate.
PubMed:
Burkholderia fungorum sp. nov. and Burkholderia caledonica sp. nov., two new species isolated from the environment, animals and human clinical samples.
PubMed:
Subsite preferences of pepstatin-insensitive carboxyl proteinases from prokaryotes: kumamolysin, a thermostable pepstatin-insensitive carboxyl proteinase.
PubMed:
Separations of enantiomers by preparative capillary isotachophoresis.
PubMed:
The effect of chlorambucil upon lysozyme activity.
PubMed:
Identification of carboxyl residues in pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. 101 that participate in catalysis and substrate binding.
PubMed:
Substrate specificities of pepstatin-insensitive carboxyl proteinases from gram-negative bacteria.
PubMed:
Characterisation of a thermostable pepstatin-insensitive acid proteinase from a Bacillus sp.
PubMed:
A pepstatin-insensitive aspartic proteinase from a thermophilic Bacillus sp.
PubMed:
Purification and some properties of a protease from Streptomyces limosus.
PubMed:
Purification and characterization of an acid proteinase from Dirofilaria immitis worms.
PubMed:
Effect of inhibitors of cell envelope synthesis on beta-sitosterol side chain degradation by Mycobacterium sp. NRRL MB 3683.
PubMed:
Purification and characterization of kumamolysin, a novel thermostable pepstatin-insensitive carboxyl proteinase from Bacillus novosp. MN-32.
PubMed:
Amino acid imbalance and intracellular protein synthesis.
PubMed:
The gene and deduced protein sequences of the zymogen of Aspergillus niger acid proteinase A.
PubMed:
Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis.
PubMed:
Purification and Characterization of an Extracellular Acid Proteinase from the Ectomycorrhizal Fungus Hebeloma crustuliniforme.
PubMed:
Methionine as methyl-group donor in the synthesis of Mycobacterium avium envelope lipids, and its inhibition by DL-ethionine, D-norleucine and DL-norleucine.
PubMed:
Tuna pepsinogens and pepsins. Purification, characterization and amino-terminal sequences.
PubMed:
Cathepsin D from human leukocytes. Purification by affinity chromatography and properties of the enzyme.
PubMed:
Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium.
PubMed:
Interference by methionine on valine uptake in Acremonium chrysogenum.
PubMed:
Purification of an acid protease from Mucor rouxii that inactivates chitin synthetase.
PubMed:
Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase.
PubMed:
Extracellular proteinases of the isolate of Botrytis cinerea virulent to apple tissues.
PubMed:
Acid proteinase activity in fish--I. Comparative study of extraction of cathepsins B and D from Mujil auratus.
PubMed:
Purification and characterization of pepsinogens and pepsins from Asiatic black bear, and amino acid sequence determination of the NH2-terminal 60 residues of the major pepsinogen.
PubMed:
Identification of monkey lung procathepsin D-II as a pepsinogen-C-like acid protease zymogen.
PubMed:
An aspartic proteinase from Fusarium moniliforme. Purification and general properties.
PubMed:
Extracellular acid proteases produced by Saccharomycopsis lipolytica.
PubMed:
Aspartyl proteinase from cucumber (Cucumis sativus) seeds. Preparation and characteristics.
PubMed:
Protease activity associated with loss of adhesiveness in mouse teratocarcinoma.
PubMed:
Proton magnetic resonance spectroscopy of an essential histidyl residue in a milk-clotting acid protease, Mucor rennin.
PubMed:
Aryl-L-aminoacylamidase activities in extracts of Streptococcus durans.
PubMed:
Photo-oxidation of a histidyl residue of milk-clotting acid protease, Mucor rennin.
PubMed:
Studies on proteinases from the digestive organs of sardine. II. Purification and characterization of two acid proteinases from the stomach.
PubMed:
Purification and properties of proteinase A from yeast.
PubMed:
Cathepsins D from rhesus monkey lung. Purification and characterization.
PubMed:
Monkey pepsinogens and pepsins. Monkey pepsinogens and pepsins. V. Purification, Characterization, and amino-terminal sequence determination of crab-eating monkey pepsinogens and pepsins.
PubMed:
[Acid proteinase of chicken liver. Purification and properties (author's transl)].
PubMed:
A cathepsin D-like acid proteinase from human gastric mucosa. Purification and characterization.
PubMed:
Inhibition of the acid proteinase from Neurospora crassa by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(4-nitrophenoxy)propane and pepstatin.
PubMed:
Purification and characterization of rat pepsinogens whose contents increase with developmental progress.
PubMed:
The structure and function of acid proteases. IX. Isolation and amino acid sequences of the peptides containing the active site aspartyl residues reactive with diazoacetyl-DL-norleucine methyl ester and 1,2-epoxy-3-(p-nitrophenoxy)propane in Rhizopus chinensis acid protease.
PubMed:
Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils.
PubMed:
Inactivation of cathepsin D from human gastric mucosa and from stomach carcinoma by diazoacetyl-DL-norleucine methyl ester.
PubMed:
Acid proteases. II. Fluorescence study of the interaction of Cladosporium acid protease with glycyl-DL-norleucine methyl ester in the presence of cupric ions.
PubMed:
The structure and function of acid proteases. VIII. Purification and characterization of cathepsins D from Japanese monkey lung.
PubMed:
Acid proteases. I. Inactivation of Cladosporium acid protease by diazoacetyl-DL-norleucine methyl ester as an active-site-directed irreversible inhibitor.
PubMed:
Sulfur metabolism of a mutant of Cephalosporium acremonium with enhanced potential to utilize sulfate for cephalosporin C production.
PubMed:
Pepsinogen C and pepsin C from gastric mucosa of Japanese monkey. Purification and characterization.
PubMed:
The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus.
PubMed:
The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin.
PubMed:
The structure and function of acid proteases. IV. Inactivation of the acid protease from Mucor pusillus by acid protease-specific inhibitors.
PubMed:
Pepsinogens and pepsins from gastric mucosa of Japanese Monkey. Purification and characterization.
PubMed:
Purification and properties of the thermostable acid protease of Penicillium duponti.
PubMed:
Effect of norleucine on mycelial fragmentation in Cephalosporium acremonium.
PubMed:
The relevance of the structure of lysine bound to Sepharose for the affinity of rabbit plasminogen;.
PubMed:
Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin.
PubMed:
Kinetics of irreversible enzyme inhibition by an unstable inhibitor.
PubMed:
The structure and function of acid proteases. Specific inactivation of an acid protease from Rhizopus chinensis by diazoacetyl-DL-norleucine methyl ester.
PubMed:
An active site peptide from pepsin C.
PubMed:
Amino acid cross resistance in Agrobacterium tumefaciens.
PubMed:
Biosynthesis of chloramphenicol. IV. Incorporation of carbon 14-labled precursors.
PubMed:
Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores.
PubMed:
Induced alterations in metabolism of DL-norleucine-2-C14 in the intact cow.
PubMed:
Metabolism of DL-alpha-aminobutyrate-3-14C and DL-norleucine-3-14C.