epsilon-caprolactone

hexamethylene oxide, 2-oxo-

CAS: 502-44-3 C6 H10 O2 MW: 114.14410000

Identification

Nameepsilon-caprolactone
IUPACoxepan-2-one
CAS Number502-44-3
EINECS207-938-1
FDA UNII56RE988L1R
Molecular FormulaC6 H10 O2
Molecular Weight114.14410000
MDL NumberMFCD00003267
Nikkaji NumberJ1.566K
Beilstein0106919

Regulatory

DG SANTE Food Contact Materialscaprolactone

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.03000 @ 25.00 °C.
Melting Point -1.00 °C. @ 760.00 mm Hg
Boiling Point 215.00 °C. @ 760.00 mm Hg, 140.00 °C. @ 35.00 mm Hg
Vapor Pressure 0.135000 mmHg @ 25.00 °C.
Flash Point 229.00 °F. TCC ( 109.44 °C. )
logP (o/w) 0.422 (est)
Soluble in water, 2.786e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 4290 mg/kg
Dermal Toxicityskin-rabbit LD50 5990 ul/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryindirect food additives: adhesives and components of coatings
Recommendation for epsilon-caprolactone usage levels up tonot for fragrance use.
Recommendation for epsilon-caprolactone flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

caprolactone 1-oxa-2-oxo cycloheptane 2-oxa cycloheptanone 2-oxo hexamethylene oxide hexamethylene oxide, 2-oxo- hexan-6-olide 6- hexanolactone 1,6- hexanolide 6- hexanolide 6- hydroxyhexan-6-olide 6- hydroxyhexanoic acid lactone oxepan-2-one 2- oxepanone placcel M PubMed: Enhanced Production of epsilon-Caprolactone by Coexpression of Bacterial Hemoglobin Gene in Recombinant Escherichia coli Expressing Cyclohexanone Monooxygenase Gene. PubMed: Biocatalytic synthesis of δ-gluconolactone and ε-caprolactone copolymers. PubMed: Controlled protein delivery from electrospun non-wovens: novel combination of protein crystals and a biodegradable release matrix. PubMed: Characterization of poly(ε-caprolactone)-based nanocomposites containing hydroxytyrosol for active food packaging. PubMed: Dual-Component System Dimethyl Sulfoxide/LiCl as a Solvent and Catalyst for Homogeneous Ring-Opening Grafted Polymerization of ε-Caprolactone onto Xylan. PubMed: Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review. PubMed: Characterisation and stability evaluation of bixin nanocapsules. PubMed: Active systems based on silver-montmorillonite nanoparticles embedded into bio-based polymer matrices for packaging applications. PubMed: Productivity of cyclohexanone oxidation of the recombinant Corynebacterium glutamicum expressing chnB of Acinetobacter calcoaceticus. PubMed: Development of nanostructured thermoregulating textile materials. PubMed: Diversity of bacterial isolates from commercial and homemade composts. PubMed: Polyester-degrading thermophilic actinomycetes isolated from different environment in Taiwan. PubMed: PLGA 90/10 and caprolactone biodegradable nerve guides for the reconstruction of the rat sciatic nerve. PubMed: Effects of chronic administration of naltrexone on appetitive behaviors of rats.