esculetin

coumarin, 6,7-dihydroxy-

CAS: 305-01-1 C9 H6 O4 MW: 178.14362000

Identification

Nameesculetin
IUPAC6,7-dihydroxychromen-2-one
CAS Number305-01-1
EINECS206-161-5
FDA UNIISM2XD6V944
Molecular FormulaC9 H6 O4
Molecular Weight178.14362000
MDL NumberMFCD00006874
Nikkaji NumberJ5.493C
Beilstein0152788
XlogP31.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 276.00 °C. @ 760.00 mm Hg
Boiling Point 469.70 °C. @ 760.00 mm Hg (est)
Flash Point 395.00 °F. TCC ( 201.50 °C. ) (est)
logP (o/w) 0.980 (est)
Soluble in water, 7.213e+004 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 1500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for esculetin usage levels up tonot for fragrance use.
Recommendation for esculetin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

barley plant barley protoplast basil leaf bean black bean shoot bean field bean shoot blueberry plant cacao bean carrot leaf chicory chicory flower chicory leaf chicory plant dandelion flower dill seed dill seed oil horseradish plant leek wild leek plant mugwort plant olive stem peanut plant poppy opium poppy pericarp tarragon shoot

Synonyms

aesculetin asculetine 2H-1- benzopyran-2-one, 6,7-dihydroxy- (9CI) cichorigenin cichoriin aglucon cichoriin aglycon coumarin, 6,7-dihydroxy- 6,7- dihydroxy-2-benzopyrone 6,7- dihydroxy-2H-1-benzopyran-2-one 6,7- dihydroxychromen-2-one 6,7- dihydroxycoumarin esculatin esculetol esculin aglucon esculin aglycon PubMed: Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes. PubMed: Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice. PubMed: Regulation of 3β-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.). PubMed: Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.). PubMed: Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris. PubMed: Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. PubMed: Changes in scopoletin concentration in cassava chips from four varieties during storage. PubMed: Inhibitory effect of esculetin on migration, invasion and matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells. PubMed: Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. PubMed: Cassava: an appraisal of its phytochemistry and its biotechnological prospects. PubMed: Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots. PubMed: Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species. PubMed: Protective effects of dietary chamomile tea on diabetic complications. PubMed: Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). PubMed: Enhancement of growth and coumarin production in hairy root cultures of witloof chicory (Cichorium intybus L.cv. Lucknow local) under the influence of fungal elicitors. PubMed: Dietary antioxidant compounds and liver health. PubMed: Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. PubMed: Disruption of putative regulatory loci in Listeria monocytogenes demonstrates a significant role for Fur and PerR in virulence. PubMed: Hibiscus protocatechuic acid or esculetin can inhibit oxidative LDL induced by either copper ion or nitric oxide donor. PubMed: Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts of Artemisia montana. PubMed: Putrescine Influences Growth and Production of Coumarins in Hairy Root Cultures of Witloof Chicory (Cichorium intybus L. cv. Lucknow Local). PubMed: Influence of Polyamines on Growth of Hairy Root Cultures of Witloof Chicory (Cichorium intybus L. cv. Lucknow Local) and Formation of Coumarins. PubMed: Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium. PubMed: Petite colony formation by Listeria monocytogenes and Listeria species grown on esculin-containing agar.