Identification

Namediethyl ether
CAS Number60-29-7
EINECS200-467-2
FDA UNII0F5N573A2Y
Molecular FormulaC4 H10 O
Molecular Weight74.12290000
MDL NumberMFCD00011646
Nikkaji NumberJ1.925I
Beilstein1696894
XlogP30.90 (est)

Regulatory

JECFA Food AdditiveDiethyl Ether
GSFA CodexView

Physical Properties

Appearance colorless clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.71500 @ 25.00 °C.
Melting Point -116.00 to -115.00 °C. @ 760.00 mm Hg
Boiling Point 34.00 to 35.00 °C. @ 760.00 mm Hg, 10.00 to 11.00 °C. @ 300.00 mm Hg
Vapor Pressure 538.000000 mmHg @ 25.00 °C.
Flash Point -40.00 °F. TCC ( -40.00 °C. )
logP (o/w) 0.890
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessolvents

Organoleptic Properties

Odor Description at 1.00 % in dipropylene glycol.

Safety Information

Oral/Parenteral Toxicityoral-rat LD50 1215 mg/kg
Dermal Toxicityskin-rabbit LD50 > 20 ml/kg
Inhalation Toxicityinhalation-dog LCLo 76000 ppm

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryextraction solvents
Recommendation for diethyl ether usage levels up tonot for fragrance use.
Recommendation for diethyl ether flavor usage levels up tonot for flavor use.

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Potential Uses

None Found

Natural Occurrence

sauromatum guttatum tea leaf

Synonyms

diethyl oxide 1,1'-oxybis ethane ether ethoxyethane ethyl ether PubMed: Development and validation of a HPLC-UV method for pazopanib quantification in human plasma and application to cancer patients in routine clinical practice. PubMed: A novel thermoalkaliphilic xylanase from Gordonia sp. is salt, solvent and surfactant tolerant. PubMed: Antioxidant activity and total phenolic contents of three Bupleurum taxa. PubMed: Determination of chloramphenicol and zeranols in pig muscle by immunoaffinity column clean-up and LC-MS/MS analysis. PubMed: Evaluation of Anti-oxidant and Acetylcholinesterase Activity and Identification of Polyphenolics of the Invasive Weed Dittrichia viscosa. PubMed: Antimicrobial effects of Caulerpa sertularioides extract on foodborne diarrhea-caused bacteria. PubMed: Chemical composition of desert willow (Salix psammophila) grown in the Kubuqi Desert, Inner Mongolia, China: bark extracts associated with environmental adaptability. PubMed: In vitro study on the antioxidant activity of a polyphenol-rich extract from Pinus brutia bark and its fractions. PubMed: Confirmatory analysis of stanozolol metabolites in bovine, pig and sheep urines using an optimized clean-up and liquid chromatography-tandem mass spectrometry. PubMed: Cornflower (Centaurea cyanus L.) honey quality parameters: chromatographic fingerprints, chemical biomarkers, antioxidant capacity and others. PubMed: Validation (in-house and collaboratory) of the quantification method for ethyl carbamate in alcoholic beverages and soy sauce by GC-MS. PubMed: Detection of Cryptosporidium oocysts in fresh calf faeces: characteristics of two simple tests and evaluation of a semi-quantitative approach. PubMed: Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. PubMed: Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. PubMed: Why food-poisoning bacteria attached to shredded cabbage are not efficiently disinfected by sodium hypochlorite (NaClO). PubMed: Dual probiotic strains suppress high fructose-induced metabolic syndrome. PubMed: Supported liquid extraction in the quantitation of plasma enterolignans using isotope dilution GC/MS with application to flaxseed consumption in healthy adults. PubMed: Bioactive and nutritive compounds in Sorghum bicolor (Guinea corn) red leaves and their health implication. PubMed: [Isolation and identification of shellfish toxins from contaminated blue mussel (Mytilus edulis) from the East China Sea]. PubMed: Determination of sphingoid bases from hydrolyzed glucosylceramide in rice and wheat by online post-column high-performance liquid chromatography with O-phthalaldehyde derivatization. PubMed: Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil. PubMed: Subchronic toxicity study of GH transgenic carp. PubMed: Analysis of free and esterified sterols in edible oils by online reversed phase liquid chromatography-gas chromatography (RPLC-GC) using the through oven transfer adsorption desorption (TOTAD) interface. PubMed: Rapid quantitative method for total brominated vegetable oil in soft drinks using ion chromatography. PubMed: Thermodynamic and structural insight into the underlying mechanisms of the phosphatidylcholine liposomes - casein associates co-assembly and functionality. PubMed: Pleiotropic increases in free non-polar lipid, glycolipid and phospholipid contents in waxy bread wheat (Triticum aestivum L.) grain. PubMed: Chlorpromazine quantification in human plasma by UPLC-electrospray ionization tandem mass spectrometry. Application to a comparative pharmacokinetic study. PubMed: Isolation and identification of antitumor promoters from the seeds of Cassia tora. PubMed: Simultaneous detection of five antibiotics in milk by high-throughput suspension array technology. PubMed: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study. PubMed: Isolation, characterization and quantification of tricin and flavonolignans in the medicinal rice Njavara (Oryza sativa L.), as compared to staple varieties. PubMed: Green pigment from Bacillus cereus M(1)(16) (MTCC 5521): production parameters and antibacterial activity. PubMed: Chemical composition and antioxidant activity of essential oils and solvent extracts of Ptychotis verticillata from Morocco. PubMed: Chemical composition and antibacterial activities of Illicium verum against antibiotic-resistant pathogens. PubMed: Ether-zymolyase ascospore isolation procedure: an efficient protocol for ascospores isolation in Saccharomyces cerevisiae yeast. PubMed: Antioxidant activity in the extracts of two edible aroids. PubMed: Antioxidant properties of various solvent extracts of potato peel, sugar beet pulp and sesame cake. PubMed: Quantitative determination of gymnodimine-A by high performance liquid chromatography in contaminated clams from Tunisia coastline. PubMed: 2-Propanol in the mobile phase reduces the time of analysis of CLA isomers by silver ion-HPLC. PubMed: A novel and sensitive method for ethinylestradiol quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry: application to a comparative pharmacokinetics study. PubMed: Selective extraction of triazine herbicides from food samples based on a combination of a liquid membrane and molecularly imprinted polymers. PubMed: Determination of dialkyl phosphates as breakdown products of organophosphorus insecticides in fruit juices by HPTLC with fluorescence detection. PubMed: Analysis of phytosterols in extra-virgin olive oil by nano-liquid chromatography. PubMed: Scavenging capacity of strawberry tree (Arbutus unedo L.) leaves on free radicals. PubMed: Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma. PubMed: Influence of prefermentative treatments to the major volatile compounds of Assyrtiko wines. PubMed: LC-DAD-MS (ESI+) analysis and antioxidant capacity of crocus sativus petal extracts. PubMed: Quantitative determination of some food dyes using digital processing of images obtained by thin-layer chromatography. PubMed: A comparison of carbon and nitrogen stable isotope ratios of fish tissues following lipid extractions with non-polar and traditional chloroform/methanol solvent systems. PubMed: Characterization of pyrazines in some Chinese liquors and their approximate concentrations. PubMed: Antimicrobial activity of extracts of the lichen Parmelia sulcata and its salazinic acid constituent. PubMed: Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits. PubMed: Facile and efficient syntheses of (3Z,6Z,9Z)-3,6,9-nonadecatriene and homologues: pheromone and attractant components of lepidoptera. PubMed: Eicosapentaenoic acid enrichment from sardine oil by argentation chromatography. PubMed: Determination of nifedipine in human plasma and its use in bioequivalence study. PubMed: Development and validation of a rapid headspace gas chromatography-mass spectrometry method for the determination of diethyl ether and acetone residues in Tween extracts of shellfish intended for mouse bioassay for diarrhoetic toxins. PubMed: Fast cleanup method for the analysis of Sudan I-IV and para red in various foods and paprika color (oleoresin) by high-performance liquid chromatography/diode array detection: focus on removal of fat and oil as fatty acid methyl esters prepared by transesterification of acylglycerols. PubMed: Solvent type affects the number, distribution, and relative quantities of volatile compounds found in sweet whey powder. PubMed: Analysis of extracted and volatile components in blackstrap molasses feed as candidate house fly attractants. PubMed: Determination of 6-gingerol in ginger (Zingiber officinale) using high-performance thin-layer chromatography. PubMed: The effects of inulin supplementation of diets with or without hydrolysed protein sources on digestibility, faecal characteristics, haematology and immunoglobulins in dogs. PubMed: Determination and levels of the biocide ortho-phenylphenol in canned beers from different countries. PubMed: Use of accelerating solvent extraction for detecting non-steroidal anti-inflammatory drugs in horse feces. PubMed: Antioxidant properties of methanolic extracts from leaves of Rhazya stricta. PubMed: Comparison of odor-active volatile compounds of fresh and smoked salmon. PubMed: Isolation of 6-methoxy gossypol and 6,6'-dimethoxy gossypol from Gossypium barbadense Sea Island cotton. PubMed: Comparison of different fluorimetric signals for the simultaneous multivariate determination of tocopherols in vegetable oils. PubMed: Importance of insoluble-bound phenolics to antioxidant properties of wheat. PubMed: Novel solid-phase extraction method to separate 4-desmethyl-, 4-monomethyl-, and 4,4'-dimethylsterols in vegetable oils. PubMed: [Analysis of phenmedipham in agricultural products by HPLC]. PubMed: Flavor profiles of full-fat and reduced-fat cheese and cheese fat made from aged Cheddar with the fat removed using a novel process. PubMed: Determination of low molecular weight alcohols including fusel oil in various samples by diethyl ether extraction and capillary gas chromatography. PubMed: Determination of 3-chloropropane-1,2-diol as its 1,3-dioxolane derivative at the microg kg-1 level: application to a wide range of foods. PubMed: Simultaneous determination of multiple phytohormones in plant extracts by liquid chromatography-electrospray tandem mass spectrometry. PubMed: Characterization of dried whey protein concentrate and isolate flavor. PubMed: The effect of anesthesia by diethyl ether or isoflurane on activity of cytochrome P450 2E1 and P450 reductases in rat liver. PubMed: Relative retention order of all isomers of cis/trans conjugated linoleic acid FAME from the 6,8- to 13,15-positions using silver ion HPLC with two elution systems. PubMed: Extraction and identification of natural antioxidant from Sideritis euboea (mountain tea). PubMed: Quantification of carvedilol in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: application to bioequivalence study. PubMed: Total lipid extraction of homogenized and intact lean fish muscles using pressurized fluid extraction and batch extraction techniques. PubMed: Preparation of fatty acid methyl esters for gas-chromatographic analysis of marine lipids: insight studies. PubMed: Ticlopidine quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study. PubMed: Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC. PubMed: New solvent systems for thin-layer chromatographic determination of nine biogenic amines in fish and squid. PubMed: Antioxidant capacity and lipophilic content of seaweeds collected from the Qingdao coastline. PubMed: Improved identification of conjugated linoleic acid isomers using silver-ion HPLC separations. PubMed: The effects of sample preparation and gas chromatograph injection techniques on the accuracy of measuring guaiacol, 4-methylguaiacol and other volatile oak compounds in oak extracts by stable isotope dilution analyses. PubMed: Evaluation of some carotenoids in grapes by reversed- and normal-phase liquid chromatography: a qualitative analysis. PubMed: Steviol quantification at the picomole level by high-performance liquid chromatography. PubMed: Identification and quantification of carotenoids including geometrical isomers in fruit and vegetable juices by liquid chromatography with ultraviolet-diode array detection. PubMed: Bromazepam determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry: a highly sensitive and specific tool for bioequivalence studies. PubMed: Compound-specific carbon isotope analysis of volatile organic compounds in the low-microgram per liter range. PubMed: Effects of coffee components on the response of GABA(A) receptors expressed in Xenopus oocytes. PubMed: Crude fat, hexanes extraction, in feed, cereal grain, and forage (Randall/Soxtec/submersion method): collaborative study. PubMed: Crude fat, diethyl ether extraction, in feed, cereal grain, and forage (Randall/Soxtec/submersion method): collaborative study. PubMed: LC-APCI-MS-MS methodology for determination of glybenclamide in human plasma. PubMed: Determination of c9,t11-CLA in major human plasma lipid classes using a combination of methylating methodologies. PubMed: A sensitive gas chromatographic-tandem mass spectrometric method for detection of alkylating agents in water: application to acrylamide in drinking water, coffee and snuff. PubMed: A quantitative lipid extraction method for residue analysis of fish involving nonhalogenated solvents. PubMed: Polar organic solvent added to an aqueous solution changes hydrolytic property of lipase. PubMed: Butyltin compounds in retail mollusc products. PubMed: Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on Epstein-Barr virus early antigen induced by tumor promoter, TPA. PubMed: Human volunteer study with PGME: eye irritation during vapour exposure. PubMed: Estimation and fortification of vitamin D3 in pasteurized process cheese. PubMed: Effects of C18 long chain fatty acids on glucose, butyrate and hydrogen degradation. PubMed: Aroma analysis of fresh and preserved onions and leek by dual solid-phase microextraction-liquid extraction and gas chromatography-mass spectrometry. PubMed: Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection. PubMed: Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips. PubMed: Determination of liposoluble vitamins in cooked meals, milk and milk products by liquid chromatography. PubMed: Quantification of nimesulide in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Application to bioequivalence studies. PubMed: Changes in lipids and sterols during composting. PubMed: Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC. PubMed: [Determination of bisphenol A in foods using GC/MS]. PubMed: [Drying ability of anhydrous sodium sulfate on wet organic solvents after liquid-liquid partition]. PubMed: Isolation of lipid and 2-alkylcyclobutanones from irradiated foods by supercritical fluid extraction. PubMed: The validity of two HPLC methods and a colorimetric PP2A assay related to the mouse bioassay in quantification of diarrhetic toxins in blue mussels (Mytilus edulis). PubMed: Normal-phase high-performance liquid chromatographic determination and identification of aldrin, dieldrin, and DDTs in eggs. PubMed: Separation of phenolic compounds by high-performance liquid chromatography with absorbance and fluorimetric detection. PubMed: A novel method to analyze betaine in chicken liver: effect of dietary betaine and choline supplementation on the hepatic betaine concentration in broiler chicks. PubMed: Fourier transform infrared determination of caffeine in roasted coffee samples. PubMed: Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway. PubMed: A model to predict water intake of a pig growing in a known environment on a known diet. PubMed: Evaluation of extracts from Gevuina avellana hulls as antioxidants. PubMed: Identification of three triterpenoids in almond hulls. PubMed: Determination of 21-hydroxydeflazacort in human plasma by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Application to bioequivalence study. PubMed: Determination of amoxicillin residues in animal tissues by solid-phase extraction and liquid chromatography with fluorescence detection. PubMed: Determination of the hop-derived phytoestrogen, 8-prenylnaringenin, in beer by gas chromatography/mass spectrometry. PubMed: Characterization of the key aroma compounds in dried fruits of the West African peppertree Xylopia aethiopica (Dunal) A. Rich (Annonaceae) using aroma extract dilution analysis. PubMed: Antiplatelet activity of soy sauce as functional seasoning. PubMed: Preparative thin-layer chromatographic separation and subsequent gas chromatographic-mass spectrometric analysis of monoacylglycerols derived from butter oil by fungal degradation. PubMed: High-performance liquid chromatography method for analyzing the antiretroviral agent efavirenz in human plasma. PubMed: Separation of deterrents to ingestive behavior of cattle from cattle feces. PubMed: Identification of conjugated linoleic acid isomers in cheese by gas chromatography, silver ion high performance liquid chromatography and mass spectral reconstructed ion profiles. Comparison of chromatographic elution sequences. PubMed: Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells. PubMed: A test to detect cane-sugar-honey. PubMed: Migration from polyamide 'microwave and roasting bags' into roast chicken. PubMed: Purification and gas chromatographic-mass spectrometric characterization of non-methylene interrupted fatty acid incorporated in rat liver. PubMed: Determination of biogenic amines in cheese. PubMed: Preference of sheep and goats for extracts from high-grain concentrate. PubMed: Use of a radioimmunoassay which detects C21 steroids with a 17, 20beta-dihydroxyl configuration to identify and measure steroids involved in final oocyte maturation in female plaice (Pleuronectes platessa). PubMed: Use of a radioimmunoassay which detects C21 steroids with a 5beta-reduced, 3alpha-hydroxylated configuration to identify and measure steroids involved in final oocyte maturation in female plaice (Pleuronectes platessa). PubMed: Potential interference by free fatty acids in determination of tricyclazole in brown rice by gas chromatography with flame thermionic detection. PubMed: Determination of phenylbutazone residues in bovine milk by liquid chromatography with UV detection. PubMed: Isolation of 4'-bromo-4,5,6,7-tetrachlorofluorescein from a synthetic mixture by pH-zone-refining counter-current chromatography with continuous pH monitoring. PubMed: Genotoxic activity of 1-nitropyrene in water from the Yodo River, Japan. PubMed: Rapid gas chromatographic screening of edible seeds, nuts and beans for non-protein and protein amino acids. PubMed: Measurement of superoxide dismutase-like activity of natural antioxidants. PubMed: Survey of organotin compounds in blended wines. PubMed: Radiochemical neutron activation analysis of Fe, Co, Zn, Sb and Se in biomedical and environmental samples. PubMed: Metabolic utilization of dietary energy and nutrients for maintenance energy requirements in sows: basis for a net energy system. PubMed: Behavioral and neuroendocrine effects of diethyl ether exposure in the mouse. PubMed: Role of gastric glutathione in smoke flavouring-induced gastric injury in rats. PubMed: Characterization of a cytosolic protein in rat liver inhibiting neutral cholesteryl ester hydrolase. PubMed: Stereoselectivity of lipases: esterification reactions of octadecylglycerol. PubMed: N,N'-diethyl-m-toluamide (m-DET): analysis of an insect repellent in human urine and serum by high-performance liquid chromatography. PubMed: Reversed-phase high-performance liquid chromatographic determination of dexamethasone in bovine tissues. PubMed: A qualitative colorimetric test for brominated vegetable oil in soft drinks. PubMed: Rapid chromatographic analysis of fatty acid anilides suspected of causing toxic oil syndrome. PubMed: Gas chromatographic-mass spectrometric determination of oxolinic acid in fish using selected ion monitoring. PubMed: Determination of N-nitrosodimethylamine in fish products using gas chromatography with nitrogen-phosphorus detection. PubMed: The effect of extrathyroidal conversion inhibitor from food-deprived animals on iodothyronines deiodination by pituitary and cerebral cortical homogenates in vitro. PubMed: [Use of gas chromatography for determining benzoic and sorbic acid levels in orange beverage and tomato concentrate]. PubMed: Chemiluminescence immunoassay for the detection and quantification of methyltestosterone residues in muscle tissue. PubMed: Spectrophotometric method for the determination of sorbic acid in various food samples with iron(III) and 2-thiobarbituric acid as reagents. PubMed: Liquid chromatographic separation and fluorometric determination of cis- and trans-isoeugenol in perfumes, colognes, and toilet waters. PubMed: Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues. PubMed: High-performance liquid chromatographic determination of nicotinamide in rat tissue samples and blood after extraction with diethyl ether. PubMed: Comparison of diethyl ether and ethyl acetate as extracting agents for recovery of Ascaris spp. and Trichuris spp. eggs. PubMed: Identification of mammalian feces by coprostanol thin layer chromatography: method development. PubMed: Arteriovenous glucose differences across the mammary gland of the fed, starved, and re-fed lactating rat. PubMed: Occurrence of pancreatic ductal cell dysplasia in rats fed with a high fat diet and ethanol. PubMed: HPLC determination of N-nitrosomethylurea in biological fluids by reaction with 4-nitrothiophenol. PubMed: High-performance liquid chromatographic screening and confirmation methods for chloramphenicol residues in meat with off-line cartridge sample clean-up and on-line diode array UV-VIS detection. PubMed: Determination of total iron in foods by isotope dilution fast atom bombardment mass spectrometry. PubMed: Attractancy toOryzaephilus surinamensis (L.) of volatile materials isolated from vacuum distillate of heat-treated carobs. PubMed: [High resolution liquid chromatography (HPLC) analysis of the vitamin A and beta-carotene content of heat-treated precooked food]. PubMed: Mutagenic nitropyrenes in foods. PubMed: Gravimetric method for the determination of insoluble and soluble dietary fibres. PubMed: The mutagenicity of some edible mushrooms in the Ames test. PubMed: Mutagenicity of hydrolysates of citrus fruit juices. PubMed: Substrate concentration changes during pregnancy in the conscious rat. PubMed: Neonatal diarrhoea in calves given milk-substitutes differing in fat source and fed by different procedures. PubMed: Rapid determination of the 3-methylhistidine content of meat using 1-fluoro-2,4-dinitrobenzene. PubMed: A field outbreak of suspected stachybotryotoxicosis in sheep. PubMed: Gluconeogenesis from storage wax in the cotyledons of jojoba seedlings. PubMed: Nitrogen retention in rats fed on diets enriched with arginine and glycine. 2. Effect of diethyl ether anaesthesia on N retention. PubMed: Estimation of zinc pheophytins, chlorophylls, and pheophytins in mixtures in diethyl ether or 80% acetone by spectrophotometry and fluorometry. PubMed: Estimation of copper pheophytins, chlorophylls, and pheophytins in mixtures in diethyl ether. PubMed: [On the contamination of milk and milk products with chlorinated hydrocarbons. I. Methods]. PubMed: Detection of antithyroid residues in meat and some organs of slaughtered animals. PubMed: The photochemistry of imidan in diethyl ether. PubMed: [A hygienic study of "PIREF" (diethyl ether of pyrocarbonic acid) and the possibility of its use in the food industry]. PubMed: 3,5-di-Tert-butyl-4-hydroxytoluene (BHT) as an artifact from diethyl ether.