Identification

Nameethoxyacetic acid
CAS Number627-03-2
EINECS210-978-2
FDA UNII467VW095BX
Molecular FormulaC4 H8 O3
Molecular Weight104.10536000
MDL NumberMFCD00004310
Nikkaji NumberJ1.694B
Beilstein1743037

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.09700 to 1.10300 @ 20.00 °C.
Pounds per Gallon - (est). 9.139 to 9.189
Refractive Index 1.41700 to 1.42000 @ 20.00 °C.
Flash Point 208.00 °F. TCC ( 97.78 °C. )
Soluble in water, 4.081e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for ethoxyacetic acid usage levels up tonot for fragrance use.
Recommendation for ethoxyacetic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

perilla leaf

Synonyms

acetic acid, ethoxy- 2- ethoxyacetic acid PubMed: Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study. PubMed: Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology. PubMed: Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether. PubMed: Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort. PubMed: Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats. PubMed: Urinary biomarkers of exposure to glycol ethers and chlorinated solvents during pregnancy: determinants of exposure and comparison with indirect methods of exposure assessment. PubMed: Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals. PubMed: Occurrence of emerging organic contaminants in a tropical urban catchment in Singapore. PubMed: Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies. PubMed: Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites. PubMed: Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds. PubMed: NP1EC degradation pathways under oxic and microxic conditions. PubMed: Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice. PubMed: The alkoxyacetic acids as calcium and magnesium chelating agents in vitro. PubMed: Inhibitory effect of ethylene glycol monoethyl ether on rat sperm motion. PubMed: Gas chromatography analysis of urinary alkoxyacetic acids as biomarkers of exposure to aliphatic alkyl ethers. PubMed: Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. PubMed: Health effects of exposure to ethylene glycol monoethyl ether in female workers. PubMed: Determination of urinary metabolites of alkyl cellosolves by solid phase extraction and GC/FID. PubMed: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. PubMed: Percutaneous penetration and metabolism of 2-ethoxyethanol. PubMed: A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate and validation of a physiologically based pharmacokinetic model for rat and human. PubMed: Evaluation of exposure to ethylene glycol monoethyl ether acetates and their possible haematological effects on shipyard painters. PubMed: Improved method to measure urinary alkoxyacetic acids. PubMed: Rat model for renal effects of 2-alkoxyalcohols and their acetates. PubMed: Elimination of methoxyacetic acid and ethoxyacetic acid in rat. PubMed: Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene. PubMed: Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates. PubMed: Gender difference in the elimination of 2-methoxyethanol, methoxyacetic acid and ethoxyacetic acid in rat. PubMed: Biomonitoring of technical grade 1-alkoxy-2-propanol acetates by analysing urinary 2-alkoxypropionic acids. PubMed: Reproductive toxicology. Ethoxyacetic acid. PubMed: Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers. PubMed: Urinary alkoxyacetic acids and renal effects of exposure to ethylene glycol ethers. PubMed: Bacterial degradation of glycol ethers. PubMed: Role of biomarkers of exposure in the assessment of health risks. PubMed: Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-. PubMed: Occupational exposure to organic solvents during paint stripping and painting operations in the aeronautical industry. PubMed: Effect of dose on the disposition of 2-ethoxyethanol after inhalation by F344/N rats. PubMed: Determination of urinary alkoxyacetic acids by a rapid and simple method for biological monitoring of workers exposed to glycol ethers and their acetates. PubMed: Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. PubMed: Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study. PubMed: Applications of biological monitoring in occupational health practice: practical application of urinary 2-ethoxyacetic acid to assess exposure to 2-ethoxyethyl acetate in large format silk-screening operations. PubMed: Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats. PubMed: Metabolism and disposition of diethylene glycol in rat and dog. PubMed: Disposition of three glycol ethers administered in drinking water to male F344/N rats. PubMed: Occupational chronic exposure to organic solvents. XIII. Glycolether exposure during the production of varnishes. PubMed: Semen quality in workers exposed to 2-ethoxyethanol. PubMed: Structure-activity relationships for the in vitro hematotoxicity of N-alkoxyacetic acids, the toxic metabolites of glycol ethers. PubMed: Analysis of ethylene glycol ether metabolites in urine by extractive alkylation and electron-capture gas chromatography. PubMed: An improved method for the determination in urine of alkoxyacetic acids. PubMed: Comparative urinary excretion of ethoxyacetic acid in man and rat after single low doses of ethylene glycol monoethyl ether. PubMed: The biological exposure index: its use in assessing chemical exposures in the workplace. PubMed: Ethoxyacetic acid: a metabolite of ethylene glycol monoethyl ether acetate in man. PubMed: Field study of the urinary excretion of ethoxyacetic acid during repeated daily exposure to the ethyl ether of ethylene glycol and the ethyl ether of ethylene glycol acetate. PubMed: Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy- and N-butoxy acetic acids in the rat. PubMed: Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether. PubMed: Methoxyacetic acid and ethoxyacetic acid inhibit mitochondrial function in vitro. PubMed: In vivo and in vitro evaluations of spermatotoxicity induced by 2-ethoxyethanol treatment. PubMed: Gas chromatographic determination of methoxyacetic and ethoxyacetic acid in urine. PubMed: The teratogenic potential of alkoxy acids in post-implantation rat embryo culture: structure-activity relationships. PubMed: Studies on the toxicity of some glycol ethers and alkoxyacetic acids in primary testicular cell cultures. PubMed: Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood and urine. PubMed: Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat. PubMed: Metabolism and excretion of 2-ethoxyethanol in the adult male rat. PubMed: Ethoxyacetic acid and N-ethoxyacetylglycine: metabolites of ethoxyethanol (ethylcellosolve) in rats.