ethylene diamine
1,2-ethylenediamine
Identification
| Name | ethylene diamine |
| IUPAC | ethane-1,2-diamine |
| CAS Number | 107-15-3 |
| EINECS | 203-468-6 |
| FDA UNII | 60V9STC53F |
| Molecular Formula | C2 H8 N2 |
| Molecular Weight | 60.09976000 |
| MDL Number | MFCD00008204 |
| Nikkaji Number | J4.057F |
| Beilstein | 0605263 |
| XlogP3 | -2.00 (est) |
Regulatory
| DG SANTE Food Contact Materials | ethylenediamine |
| FDA Mainterm (SATF) | 107-15-3 ; ETHYLENEDIAMINE |
| FDA Regulation | FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.89700 to 0.90000 @ 20.00 °C. |
| Pounds per Gallon - (est). | 7.473 to 7.498 |
| Refractive Index | 1.45600 to 1.45800 @ 20.00 °C. |
| Melting Point | 11.00 to 12.00 °C. @ 760.00 mm Hg |
| Boiling Point | 117.00 to 118.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 15.778000 mmHg @ 25.00 °C. (est) |
| Flash Point | 93.00 °F. TCC ( 33.89 °C. ) |
| logP (o/w) | -2.040 (est) |
| Soluble in | water, 1000000 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 1200 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 730 ul/kg |
| Inhalation Toxicity | inhalation-mouse LC50 300 mg/m3 |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | food-contact surface of paper and paperboard |
| Recommendation for ethylene diamine usage levels up to | not for fragrance use. |
| Recommendation for ethylene diamine flavor usage levels up to | not for flavor use. |
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Human Chemistry
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Potential Uses
Natural Occurrence
Synonyms
beta-
aminoethylamine
1,2-
diamino ethane
1,2-
diaminoethane
1,4-
diazabutane
dimethylenediamine
ethane-1,2-diamine
1,2-
ethanediamine
ethylenediamine
1,2-
ethylenediamine
PubMed:
Graphene Oxide Sheets Immobilized Polystyrene for Column Preconcentration and Sensitive Determination of Lead by Flame Atomic Absorption Spectrometry.
PubMed:
Separation of digesta fractions complicates estimation of ileal digestibility using marker methods with Cr2O3 and cobalt-ethylenediamine tetraacetic acid in broiler chickens.
PubMed:
Cationic β-lactoglobulin nanoparticles as a bioavailability enhancer: comparison between ethylenediamine and polyethyleneimine as cationizers.
PubMed:
Immobilization of Thermomyces lanuginosus lipase by different techniques on Immobead 150 support: characterization and applications.
PubMed:
Optimization of medium composition for cis,cis-muconic acid production by a Pseudomonas sp. mutant using statistical methods.
PubMed:
Hydrogen peroxide regulated photosynthesis in C4-pepc transgenic rice.
PubMed:
Cytotoxic effects of procyanidins from Castanea mollissima Bl. shell on human hepatoma G2 cells in vitro.
PubMed:
Alternative chelating agents: evaluation of the ready biodegradability and complexation properties.
PubMed:
Covalent immobilization of mixed proteases, trypsin and chymotrypsin, onto modified polyvinyl chloride microspheres.
PubMed:
Immunoassay for lead ions: analysis of spiked food samples.
PubMed:
Planar chromatography mediated screening of tetracycline and fluoroquinolone antibiotics in milk by fluorescence and mass selective detection.
PubMed:
Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin--modulation by Nrf2.
PubMed:
Application of an isocratic methanol-based HPLC method for the determination of iohexol concentrations and glomerular filtration rate in patients with cirrhosis.
PubMed:
Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis.
PubMed:
Cationic β-lactoglobulin nanoparticles as a bioavailability enhancer: protein characterization and particle formation.
PubMed:
Sex-specific effects of isolation stress and consumption of palatable diet during the prepubertal period on metabolic parameters.
PubMed:
A multi-class, multi-analyte method for routine analysis of 84 veterinary drugs in chicken muscle using simple extraction and LC-MS/MS.
PubMed:
Visual sensor for the detection of trace Cu(II) ions using an immunochromatographic strip.
PubMed:
Determination of nitrite in meat products and water using dapsone with combined spot test/diffuse reflectance on filter paper.
PubMed:
Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions.
PubMed:
Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A.
PubMed:
Anti-inflammatory effects of a special carbohydrate-whey protein cake after exhaustive cycling in humans.
PubMed:
Immobilization of β-galactosidase from Kluyveromyces lactis onto polymeric membrane surfaces: effect of surface characteristics.
PubMed:
Oxidative stress, inflammation and angiogenesis markers in elite female water polo athletes throughout a season.
PubMed:
Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine.
PubMed:
[Analysis of 112 pesticide residues in vegetables using dispersive-solid phase extraction and gas chromatography-triple quadrupole mass spectrometry].
PubMed:
Immobilization of β-galactosidase on modified polypropilene membranes.
PubMed:
Efficiency of a new strategy involving a new class of natural hetero-ligand iron(III) chelates (Fe(III)-NHL) to improve fruit tree growth in alkaline/calcareous soils.
PubMed:
Comparative analysis of cholinesterase activities in food animals using modified Ellman and Michel assays.
PubMed:
Polyethylene glycol grafted polyethylene: a versatile platform for nonmigratory active packaging applications.
PubMed:
Development of an iron chelating polyethylene film for active packaging applications.
PubMed:
[Determination of 88 pesticide residues in cranberry plant extract by gas chromatography-triple quadrupole tandem mass spectrometry].
PubMed:
Electrochemical sensor using methimazole imprinted polymer sensitized with MWCNTs and Salen-Co(III) as recognition element.
PubMed:
Simultaneous mobilization of macro- and trace elements (MTEs) and polycyclic aromatic hydrocarbon (PAH) compounds from soil with a nonionic surfactant and [S,S]-ethylenediaminedisuccinic acid (EDDS) in admixture: PAH compounds.
PubMed:
Demetalation of Fe, Mn, and Cu chelates and complexes: application to the NMR analysis of micronutrient fertilizers.
PubMed:
Charge modifications to improve the emulsifying properties of whey protein isolate.
PubMed:
Factors influencing diamine oxidase activity and γ-aminobutyric acid content of fava bean (Vicia faba L.) during germination.
PubMed:
Survival of Escherichia coli O157:H7 in meat product brines containing antimicrobials.
PubMed:
Inhibition effect of belzalkonium chloride treatment on growth of common food contaminating fungal species.
PubMed:
ELISA and some biochemical tests of heterophyidae infection in laboratory animals.
PubMed:
Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons.
PubMed:
Synergic antimicrobial activity of lysozyme, nisin, and EDTA against Listeria monocytogenes in ostrich meat patties.
PubMed:
Influence of irradiation time and solution concentration on the photochemical degradation of EDDHA/Fe3+: effect of its photodecomposition products on soybean growth.
PubMed:
Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats.
PubMed:
Scaling up a treatment to simultaneously remove persistent organic pollutants and heavy metals from contaminated soils.
PubMed:
Influence of the soil/solution ratio, interaction time, and extractant on the evaluation of iron chelate sorption/desorption by soils.
PubMed:
Performance of soil-applied FeEDDHA isomers in delivering Fe to soybean plants in relation to the moment of application.
PubMed:
Effect of preheating temperature on the microstructure of walleye pollack surimi gels under the inhibition of the polymerisation and degradation of myosin heavy chain.
PubMed:
Interaction between beet vinasse and iron fertilisers in the prevention of iron deficiency in lupins.
PubMed:
Quantification of folate in fruits and vegetables: A fluorescence-based homogeneous assay.
PubMed:
Formulation of 68Ga BAPEN kit for myocardial positron emission tomography imaging and biodistribution study.
PubMed:
Quantifying dispersal of Diaphorina citri (Hemiptera: Psyllidae) by immunomarking and potential impact of unmanaged groves on commercial citrus management.
PubMed:
Chemical evaluation of HBED/Fe(3+) and the novel HJB/Fe(3+) chelates as fertilizers to alleviate iron chlorosis.
PubMed:
Open sandwich-based immuno-transistor for label-free and noncompetitive detection of low molecular weight antigen.
PubMed:
Preconcentration and separation of trace amount of copper (II) on N1, N2-bis(4-fluorobenzylidene)ethane-1,2-diamine loaded on Sepabeads SP70.
PubMed:
Facile deferration of commercial fertilizers containing iron chelates for their NMR analysis.
PubMed:
Growth parameters of Escherichia coli O157:H7, Salmonella spp., Listeria monocytogenes, and aerobic mesophilic bacteria of apple cider amended with nisin-EDTA.
PubMed:
Facile fabrication of well-defined hydrogel beads with magnetic nanocomposite shells.
PubMed:
Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats.
PubMed:
Immobilization of a thermostable alpha-amylase by covalent binding to an alginate matrix increases high temperature usability.
PubMed:
A fluorescence polarization immunoassay for the detection of zearalenone in corn.
PubMed:
Sodium caseinates with an altered isoelectric point as emulsifiers in oil/water systems.
PubMed:
Dispersive solid-phase extraction followed by liquid chromatography-tandem mass spectrometry for the multi-residue analysis of pesticides in raw bovine milk.
PubMed:
Fluorescence detection of tyrosinase activity on dopamine-betaxanthin purified from Portulaca oleracea (common purslane) flowers.
PubMed:
Methoxy VO-salen complex: in vitro antioxidant activity, cytotoxicity evaluation and protective effect on CCl4-induced oxidative stress in rats.
PubMed:
Application of immobilized horseradish peroxidase onto modified acrylonitrile copolymer membrane in removing of phenol from water.
PubMed:
[N,N,N',N'-Tetra-kis(benzimidazol-2-yl-meth-yl)ethane-1,2-diamine]copper(II) sulfate monohydrate.
PubMed:
Evaluation of antibacterial activity of whey protein isolate coating incorporated with nisin, grape seed extract, malic acid, and EDTA on a Turkey frankfurter system.
PubMed:
Efficacy of Fe(o,o-EDDHA) and Fe(o,p-EDDHA) isomers in supplying Fe to strategy I plants differs in nutrient solution and calcareous soil.
PubMed:
[Identification of catalytically active groups of wheat (Triticum aestivum L.) germ lipase].
PubMed:
Modification of AOAC method 973.31 for determination of nitrite in cured meats.
PubMed:
Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.
PubMed:
Zinc deficiency decreased cell viability both in endothelial EA.hy926 cells and mouse aortic culture ex vivo and its implication for anti-atherosclerosis.
PubMed:
Uptake of Zn and Fe by wheat (Triticum aestivum var. Greina) and transfer to the grains in the presence of chelating agents (ethylenediaminedisuccinic acid and ethylenediaminetetraacetic acid).
PubMed:
Fungi and macroaggregation in deep-sea sediments.
PubMed:
Kinetic behavior of Fe(o,o-EDDHA)-humic substance mixtures in several soil components and in calcareous soils.
PubMed:
Simultaneous determination of iron and aluminium by differential kinetic spectrophotometric method and chemometrics.
PubMed:
Influence of micronutrients on rheological characteristics and bread-making quality of flour.
PubMed:
Preparation of specific monoclonal antibodies (MAbs) against heavy metals: MAbs that recognize chelated cadmium ions.
PubMed:
Behavior of zinc from six organic fertilizers applied to a navy bean crop grown in a calcareous soil.
PubMed:
A simple capillary gel electrophoresis approach for efficient and reproducible DNA separations. Analysis of genetically modified soy and maize.
PubMed:
Comparative studies on storage stability of ferrous iron in whole wheat flour and flat bread (naan).
PubMed:
Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells.
PubMed:
Effect of high hydrostatic pressure on four genotypes of F-specific RNA bacteriophages.
PubMed:
Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes.
PubMed:
Comparison of extracellular and intracellular potency of botulinum neurotoxins.
PubMed:
Growth stimulation of Brevibacterium sp. by siderophores.
PubMed:
Removable colored coatings based on calcium alginate hydrogels.
PubMed:
Structure and fertilizer properties of byproducts formed in the synthesis of EDDHA.
PubMed:
A rapid confirmatory method for analyzing tetracycline antibiotics in bovine, swine, and poultry muscle tissues: matrix solid-phase dispersion with heated water as extractant followed by liquid chromatography-tandem mass spectrometry.
PubMed:
Fe uptake from meso and D,L-racemic Fe(o,o-EDDHA) isomers by strategy I and II plants.
PubMed:
Chromatographic determination of Fe chelated by ethylenediamine-N-(o-hydroxyphenylacetic)-N'-(p-hydroxyphenylacetic) acid in commercial EDDHA/Fe3+ fertilizers.
PubMed:
The receptor of an oyster juice-borne coliphage OJ367 in the outer membrane of Salmonella derby.
PubMed:
Multiresidue determination of fluoroquinolones in shrimp by liquid chromatography-fluorescence-mass spectrometry.
PubMed:
Immobilization and biocatalysis of chlorophyllase in selected organic solvent systems.
PubMed:
Plasma-enhanced modification of xanthan gum and its effect on rheological properties.
PubMed:
Transition of the probiotic bacteria, Lactobacillus casei strain Shirota, in the gastrointestinal tract of a pig.
PubMed:
Effect of hydrogen peroxide and other protease inhibitors on Cryptosporidium parvum excystation and in vitro development.
PubMed:
Electroanalytical determination and fractionation of copper in wine.
PubMed:
The role of EDTA in malonaldehyde formation from DNA oxidized by Fenton reagent systems.
PubMed:
Amperometric biosensor based on denatured DNA for the study of heavy metals complexing with DNA and their determination in biological, water and food samples.
PubMed:
Study on the effect of food on the absorption of theophylline.
PubMed:
Cations reduce antimicrobial efficacy of lysozyme-chelator combinations.
PubMed:
Stabilization of a multimeric beta-galactosidase from Thermus sp. strain T2 by immobilization on novel heterofunctional epoxy supports plus aldehyde-dextran cross-linking.
PubMed:
Effect of iron limitation on the growth and cytotoxin production of Salmonella choleraesuis SC-5.
PubMed:
Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties.
PubMed:
Effects of zinc complexes on the distribution of zinc in calcareous soil and zinc uptake by maize.
PubMed:
Theoretical speciation of ethylenediamine-N-(o-hydroxyphenylacetic)-N'-(p-hydroxyphenylacetic) acid (o,p-EDDHA) in agronomic conditions.
PubMed:
A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells.
PubMed:
Extraction and characterization of collagen with or without telopeptides from chicken skin.
PubMed:
HPLC method for determining ethylenediamine migration from epoxy-amine food packaging coatings into EU food simulants.
PubMed:
Synthesis of o,p-EDDHA and its detection as the main impurity in o,o-EDDHA commercial iron chelates.
PubMed:
Response of Staphylococcus aureus isolates from bovine mastitis to exogenous iron sources.
PubMed:
Zinc transformations in acidic soil and zinc efficiency on maize by adding six organic zinc complexes.
PubMed:
Nature of impurities in fertilizers containing EDDHMA/Fe(3+), EDDHSA/Fe(3+), and EDDCHA/Fe(3+) chelates.
PubMed:
Genotoxicity of iron chelators in L5178Y mouse lymphoma cells.
PubMed:
Fe(III)-EDDHA and -EDDHMA sorption on Ca-montmorillonite, ferrihydrite, and peat.
PubMed:
Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis.
PubMed:
NMR analysis of the iron ligand ethylenediaminedi(o-hydroxyphenyl)acetic acid (EDDHA) employed in fertilizers.
PubMed:
Inhibition of lignin peroxidase-mediated oxidation activity by ethylenediamine tetraacetic acid and N-N-N'-N'-tetramethylenediamine.
PubMed:
Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes.
PubMed:
Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha.
PubMed:
Improvement in the determination of mancozeb residues by the carbon disulfide evolution method using flow injection analysis.
PubMed:
Chronic toxicity and carcinogenicity studies of ethylenediamine dihydrochloride by dietary incorporation in Fischer 344 rats.
PubMed:
A model system for convenient fluorescent labeling of sugar chain in taka-amylase A.
PubMed:
Simultaneous spectrophotometric determination of nitrite and nitrate by flow-injection analysis.
PubMed:
Perturbations in blood Ca(2)+ do not affect the activity of rat stomach enterochromaffin-like cells.
PubMed:
Water-soluble carbodiimide for the fluorescent measurement of the carboxyl group produced by enzyme reactions.
PubMed:
An animal model of necrotizing enterocolitis induced by infant formula and ischemia in developing piglets.
PubMed:
A method for measuring nitrite in fresh vegetables.
PubMed:
An active-site peptide containing the second essential carboxyl group of dextransucrase from Leuconostoc mesenteroides by chemical modifications.
PubMed:
Analysis of hapten-carrier protein conjugates by nondenaturing gel electrophoresis.
PubMed:
Inhibitory effect against pathogenic and spoilage bacteria of Pseudomonas strains isolated from spoiled and fresh fish.
PubMed:
An improved high-performance liquid chromatographic assay for the determination of pyridinoline in connective tissues.
PubMed:
Oxidative damage in the red cells of vitamin E-deficient rats.
PubMed:
Immobilization of invertase through its carbohydrate moiety on Ocimum basilicum seed.
PubMed:
Dibasic amines as competitive ions improve the resolution between polyanionic nucleotides.
PubMed:
Kinetic determination of iodide in pharmaceutical and food samples.
PubMed:
[Nitrate and nitrite levels in daily food rations of children from the rural PuÅawy regions].
PubMed:
Improved extraction method for avoiding the interference of ascorbic acid in the spectrophotometric determination of nitrite in meat products.
PubMed:
Direct analysis of microbial extracts containing metabolites of ethylenediamine-type antihistamines via high-performance liquid chromatography-thermospray mass spectrometry.
PubMed:
Iodine in milk and meat of dairy cows fed different amounts of potassium iodide or ethylenediamine dihydroiodide.
PubMed:
Production and characterization of antibodies against microcystins.
PubMed:
Fast-atom bombardment and thermospray mass spectrometry for the characterization of two glucuronide metabolites of methapyrilene.
PubMed:
Extracorporeal complexation and haemodialysis for the treatment of cadmium poisoning. I. Effects of four chelators on the in vitro elimination of cadmium from human blood.
PubMed:
[Distinction between sodium chlorite and sodium hypochlorite by ion-chromatography].
PubMed:
Intestinal permeability to chromium-51 ethylenediamine tetraacetic acid in children with chronic obstructive respiratory disease: relationship with clinical and duodenal biopsy findings.
PubMed:
Evaluation of the teratogenicity of ethylenediamine dihydrochloride in Fischer 344 rats by conventional and pair-feeding studies.
PubMed:
Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids.
PubMed:
Effect of pH on absorbance of azo dye formed by reaction between nitrite and sulfanilamide/N-(1-naphthyl)ethylenediamine in residual nitrite methods for foods.
PubMed:
Milk production, nutrient digestion, and rate of digesta passage in dairy cows fed long or chopped alfalfa hay supplemented with sodium bicarbonate.
PubMed:
Controlling growth of Streptococcus faecium in a ham model with heat and ethylenediamine tetraacetic acid, tertiary butylhydroquinone or nisin.
PubMed:
Comparison of chemiluminescent and AOAC methods for determining nitrite in commercial cured meat products.
PubMed:
Iodine in field milk samples and effects on mastitis organisms.
PubMed:
Effects of excessive iodide administered in the dry period on thyroid function and health of dairy cows and their calves in the periparturient period.
PubMed:
[Allergic contact dermatitis to ethylenediamine in skin grafts for burns].
PubMed:
Toxicology of ethylenediamine dihydriodide.
PubMed:
Investigation of chromium, cerium and cobalt as markers in digesta. Rate of passage studies.
PubMed:
Improved colorimetric method for determining nitrate and nitrate in foods.
PubMed:
(-)-Hydroxycitrate and conditioned aversions.
PubMed:
Residues of maneb, ethylenethiuram monosulfide, ethylenethiourea, and ethylenediamine on beans and tomatoes field treated with maneb.
PubMed:
Nuclear magnetic resonance analysis of pharmaceuticals-VII Determination of aminophylline in tablets.
PubMed:
Ethylenediamine tetraacetic acid. A new biological preservative for beer.
PubMed:
The accumulation of zinc by the mosquito.