thimerosal

ethyl mercurithiosalicylic acid sodium salt

CAS: 54-64-8 C9 H9 Hg Na O2 S MW: 404.81389928

Identification

Namethimerosal
IUPACsodium;(2-carboxylatophenyl)sulfanyl-ethylmercury
CAS Number54-64-8
EINECS200-210-4
FDA UNII2225PI3MOV
Molecular FormulaC9 H9 Hg Na O2 S
Molecular Weight404.81389928
MDL NumberMFCD00013062
Beilstein8169555

Regulatory

Physical Properties

Appearance light cream-colored crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1.146e+005 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-man TDLo 28571 ug/kg/10
Dermal Toxicitysubcutaneous-mouse LD50 66 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for thimerosal usage levels up tonot for fragrance use.
Recommendation for thimerosal flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

ethyl mercurithiosalicylic acid sodium salt sodium;(2-carboxylatophenyl)sulfanyl-ethylmercury PubMed: Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway. PubMed: Ethylmercury and Hg(2+) induce the formation of neutrophil extracellular traps (NETs) by human neutrophil granulocytes. PubMed: Risk factors associated with anaphylaxis and other allergic-like events following receipt of 2009 monovalent AS03-adjuvanted pandemic influenza vaccine in Quebec, Canada. PubMed: Milestone achievement and neurodevelopment of rural Amazonian toddlers (12 to 24 months) with different methylmercury and ethylmercury exposure. PubMed: Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response. PubMed: Perinatal multiple exposure to neurotoxic (lead, methylmercury, ethylmercury, and aluminum) substances and neurodevelopment at six and 24 months of age. PubMed: Total mercury content in canine hair before and after administration of vaccines containing thiomersal. PubMed: A systematic review of validated methods to capture several rare conditions using administrative or claims data. PubMed: A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. PubMed: Breast-feeding and responses to infant vaccines: constitutional and environmental factors. PubMed: Hypersensitivity reactions to vaccine constituents: a case series and review of the literature. PubMed: Effect of duration of breastfeeding on neuropsychological development at 10 to 12 years of age in a cohort of healthy children. PubMed: Evaluation of thimerosal removal on immunogenicity of aluminum salts adjuvanted recombinant hepatitis B vaccine. PubMed: The most important contact sensitizers in Polish children and adolescents with atopy and chronic recurrent eczema as detected with the extended European Baseline Series. PubMed: Research into mercury exposure and health education in subsistence fish-eating communities of the Amazon basin: potential effects on public health policy. PubMed: Hair methylmercury and therapeutic monitoring. PubMed: Effects of glucan on immunosuppressive actions of mercury. PubMed: Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture. PubMed: Update on autism and childhood vaccines. PubMed: Mercury, vaccines, and autism, revisited. PubMed: Fish consumption, methylmercury and child neurodevelopment. PubMed: Mercury, vaccines, and autism: one controversy, three histories. PubMed: Inactivated influenza vaccine (IIV) in children <2 years of age: examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine. PubMed: Ethylmercury and breastfeeding as confounders in outcomes of functional programming: Where are they? PubMed: A review of Thimerosal (Merthiolate) and its ethylmercury breakdown product: specific historical considerations regarding safety and effectiveness. PubMed: Vaccines and autism: evidence does not support a causal association. PubMed: Thimerosal and vaccines--a cautionary tale. PubMed: Changes in children hair-Hg concentrations during the first 5 years: maternal, environmental and iatrogenic modifying factors. PubMed: Perinatal hepatitis B transmission and vaccination timing in a managed care cohort: assessment of the temporary delay in newborn hepatitis B vaccination due to thimerosal content. PubMed: Rapid method for detection of Salmonella in milk by surface plasmon resonance (SPR). PubMed: Analysis of acrylamide in food products by in-line preconcentration capillary zone electrophoresis. PubMed: Immuno-biochemical evaluations of phenol and thimerosal as antigen preservatives in Montenegro skin test. PubMed: Antioxidant activity of cysteine, tryptophan, and methionine residues in continuous phase beta-lactoglobulin in oil-in-water emulsions. PubMed: [Allergies in adults]. PubMed: It did happen here: fear and loathing on the vaccine trail. PubMed: Determination of egg proteins in snack food and noodles. PubMed: A comparative study of the sensitivity of the 3-induction and 9-induction Buehler test procedures for assessing skin sensitisation potential. PubMed: Understanding the mercury reduction issue: the impact of mercury on the environment and human health. PubMed: Preparation of peanut butter suspension for determination of peanuts using enzyme-linked immunoassay kits. PubMed: [Mercury in vaccines]. PubMed: An assessment of the impact of thimerosal on childhood neurodevelopmental disorders. PubMed: Organic mercury compounds: human exposure and its relevance to public health. PubMed: Epidemiology. Vaccine-autism link dealt blow. PubMed: Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. PubMed: Vaccine safety policy analysis in three European countries: the case of thimerosal. PubMed: Autism, an extreme challenge to integrative medicine. Part: 1: The knowledge base. PubMed: Type IV allergy in the food processing industry: sensitization profiles in bakers, cooks and butchers. PubMed: The process of public policy formulation: the case of thimerosal in vaccines. PubMed: The three modern faces of mercury. PubMed: Predicted mercury concentrations in hair from infant immunizations: cause for concern. PubMed: An assessment of thimerosal use in childhood vaccines. PubMed: From the Food and Drug Administration. PubMed: Availability of hepatitis B vaccine that does not contain thimerosal as a preservative. PubMed: Review on the toxicity of ethylmercury, including its presence as a preservative in biological and pharmaceutical products. PubMed: Update: expanded availability of thimerosal preservative-free hepatitis B vaccine. PubMed: Mercury, infant neurodevelopment, and vaccination. PubMed: Recommendations regarding the use of vaccines that contain thimerosal as a preservative. PubMed: Limiting infant exposure to thimerosal in vaccines and other sources of mercury. PubMed: Thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service. PubMed: Thimerosal in vaccines--An interim report to clinicians. American Academy of Pediatrics. Committee on Infectious Diseases and Committee on Environmental Health. PubMed: Thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service. PubMed: Deleterious effect of thimerosal on the potency of inactivated poliovirus vaccine. PubMed: The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor. PubMed: Comparative efficacy of contact lens disinfection solutions. PubMed: The use of yeast cultures for the detection of environmental mutagens using a fluctuation test. PubMed: Hazards to 131-I estimation in thimerosal preserved milk. PubMed: THIMEROSAL, A PRESERVATIVE FOR MILK TO BE TESTED FOR RADIOACTIVITY.