flavone
2-phenyl-1,4-benzopyrone
Identification
| Name | flavone |
| IUPAC | 2-phenylchromen-4-one |
| CAS Number | 525-82-6 |
| EINECS | 208-383-8 |
| FDA UNII | S2V45N7G3B |
| Molecular Formula | C15 H10 O2 |
| Molecular Weight | 222.24310000 |
| MDL Number | MFCD00006825 |
| Nikkaji Number | J53.111A |
| Beilstein | 0157598 |
| XlogP3 | 3.60 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 97.00 to 100.00 °C. @ 760.00 mm Hg |
| Boiling Point | 367.00 to 368.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000014 mmHg @ 25.00 °C. (est) |
| Flash Point | 340.00 °F. TCC ( 171.10 °C. ) (est) |
| logP (o/w) | 3.560 |
| Soluble in | alcohol |
| Insoluble in | water |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD50 2500 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD > 400 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for flavone usage levels up to | not for fragrance use. |
| Recommendation for flavone flavor usage levels up to | not for flavor use. |
Penta International Corporation
Chemistry innovation
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Potential Uses
Natural Occurrence
Synonyms
asmacoril
4H-1-
benzopyran-4-one, 2-phenyl-
chromocor
cromaril
cromarile
2-
phenyl-1,4-benzopyrone
2-
phenyl-4-benzopyron
2-
phenyl-4-chromone
2-
phenyl-4H-1-benzopyran-4-one
2-
phenyl-4H-benzopyran-4-one
2-
phenyl-4H-chromen-4-on
2-
phenyl-4H-chromen-4-one
2-
phenyl-chromen-4-one
2-
phenyl-g-benzopyrone
2-
phenyl-gamma-benzopyrone
2-
phenylbenzopyran-4-one
2-
phenylchromen-4-one
2-
phenylchromone
PubMed:
Comprehensive Phenolic Profiling of Cyclopia genistoides (L.) Vent. by LC-DAD-MS and -MS/MS Reveals Novel Xanthone and Benzophenone Constituents.
PubMed:
Rapid screening of low molecular weight phenols from persimmon (Diospyros kaki) pulp using liquid chromatography-UV/Vis-electrospray mass spectrometry analysis.
PubMed:
Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).
PubMed:
The occurrence, fate and biological activities of C-glycosyl flavonoids in the human diet.
PubMed:
Characteristics of an Organic Solvent-Tolerant β-Fructofuranosidase from Arthrobacter arilaitensis NJEM01 and Efficient Synthesis of Prebiotic Kestose.
PubMed:
Using an FFQ to assess intakes of dietary flavonols and flavones among female adolescents in the Suihua area of northern China.
PubMed:
Phytochemicals and antioxidant activities of Rhus tripartitum (Ucria) fruits depending on locality and different stages of maturity.
PubMed:
Stimulation of Osteogenic Activity in Human Osteoblast Cells by Edible Uraria crinita.
PubMed:
Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells.
PubMed:
Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary.
PubMed:
Metabolite profiling of polyphenols in peels of Citrus limetta Risso by combination of preparative high-speed countercurrent chromatography and LC-ESI-MS/MS.
PubMed:
Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens.
PubMed:
Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats.
PubMed:
Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells.
PubMed:
Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'.
PubMed:
Soluble Phenolic Compounds in Fresh and Ensiled Orchard Grass ( Dactylis glomerata L.), a Common Species in Permanent Pastures with Potential as a Biomass Feedstock.
PubMed:
Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women.
PubMed:
α-Glucosidase inhibition by luteolin: kinetics, interaction and molecular docking.
PubMed:
First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties.
PubMed:
Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
PubMed:
Wheat straw biomass: a resource for high-value chemicals.
PubMed:
Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation.
PubMed:
Antioxidant activity of phenolics in leaves of three red pepper (Capsicum annuum) cultivars.
PubMed:
Characterisation of phenolic compounds in wild fruits from Northeastern Portugal.
PubMed:
Bioactive compounds present in the Mediterranean sofrito.
PubMed:
Phenolic content of strawberry spreads during processing and storage.
PubMed:
Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis.
PubMed:
Fuzhuanins A and B: the B-ring fission lactones of flavan-3-ols from Fuzhuan brick-tea.
PubMed:
Caecal absorption of vitexin-2-O-xyloside and its aglycone apigenin, in the rat.
PubMed:
[Biologically active substances of plant origin. Flavonols and flavones: prevalence, dietary sourses and consumption].
PubMed:
Effects of food formulation and thermal processing on flavones in celery and chamomile.
PubMed:
Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats.
PubMed:
Enrichment and antioxidant properties of flavone C-glycosides from trollflowers using macroporous resin.
PubMed:
Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.
PubMed:
Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity.
PubMed:
Tea and non-tea flavonol intakes in relation to atherosclerotic vascular disease mortality in older women.
PubMed:
Flavonoids from the capitula of Eriocaulon australe.
PubMed:
Identification of a nitric oxide generation-stimulative principle in Scutellariae radix.
PubMed:
Identification of phenolic constituents in red chicory salads (Cichorium intybus) by high-performance liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry.
PubMed:
Winter wheat hull (husk) is a valuable source for tricin, a potential selective cytotoxic agent.
PubMed:
Structural characterization of lignin isolated from coconut (Cocos nucifera) coir fibers.
PubMed:
Identification of flavone glucuronide isomers by metal complexation and tandem mass spectrometry: regioselectivity of uridine 5'-diphosphate-glucuronosyltransferase isozymes in the biotransformation of flavones.
PubMed:
Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety.
PubMed:
Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods.
PubMed:
Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity.
PubMed:
Rapid resolution liquid chromatography-electrospray ionisation tandem mass spectrometry method for identification of chemical constituents in Citri Reticulatae Pericarpium.
PubMed:
Phenolic Compounds from Halimodendron halodendron (Pall.) Voss and Their Antimicrobial and Antioxidant Activities.
PubMed:
Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae.
PubMed:
The risk of lung cancer related to dietary intake of flavonoids.
PubMed:
Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells.
PubMed:
Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women.
PubMed:
Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants.
PubMed:
Identification of 5,7,3',4'-tetramethoxyflavone metabolites in rat urine by the isotope-labeling method and ultrahigh-performance liquid chromatography-electrospray ionization-mass spectrometry.
PubMed:
Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
PubMed:
Structural characterization of wheat straw lignin as revealed by analytical pyrolysis, 2D-NMR, and reductive cleavage methods.
PubMed:
Habitual flavonoid intakes are positively associated with bone mineral density in women.
PubMed:
A new lignan with anti-tumour activity from Polygonum perfoliatum L.
PubMed:
Pretreatment with the total flavone glycosides of Flos Abelmoschus manihot and hyperoside prevents glomerular podocyte apoptosis in streptozotocin-induced diabetic nephropathy.
PubMed:
Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii.
PubMed:
Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells.
PubMed:
Re-examination of chromogenic quantitative assays for determining flavonoid content.
PubMed:
Flavone deglycosylation increases their anti-inflammatory activity and absorption.
PubMed:
Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal.
PubMed:
Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing.
PubMed:
Endogenous enzymes, heat, and pH affect flavone profiles in parsley (Petroselinum crispum var. neapolitanum) and celery (Apium graveolens) during juice processing.
PubMed:
Phenolic compounds and anti-oxidant capacity of twelve morphologically heterogeneous bamboo species.
PubMed:
Antioxidant and cytotoxic activities of ethanolic extracts and isolated fractions of species of the genus Phellinus Quél. (Aphyllophoromycetideae).
PubMed:
Apigenin-induced suicidal erythrocyte death.
PubMed:
Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo.
PubMed:
In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31.
PubMed:
Flavonoids in tropical citrus species.
PubMed:
Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships.
PubMed:
Noncovalent interaction of dietary polyphenols with common human plasma proteins.
PubMed:
Liquid chromatography-tandem mass spectrometry analysis allows the simultaneous characterization of C-glycosyl and O-glycosyl flavonoids in stingless bee honeys.
PubMed:
Electrooxidation of flavonoids at platinum electrode studied by cyclic voltammetry.
PubMed:
Phenylethanoid glycosides as major antioxidants in Lippia multiflora herbal infusion and their stability during steam pasteurisation of plant material.
PubMed:
Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.
PubMed:
Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells.
PubMed:
Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities.
PubMed:
Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways.
PubMed:
Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.
PubMed:
ZnO-ZnS QDs interfacial heterostructure for drug and food delivery application: enhancement of the binding affinities of flavonoid aglycones to bovine serum albumin.
PubMed:
Approach to the study of C-glycosyl flavones acylated with aliphatic and aromatic acids from Spergularia rubra by high-performance liquid chromatography-photodiode array detection/electrospray ionization multi-stage mass spectrometry.
PubMed:
Identification of proanthocyanidin dimers and trimers, flavone C-Glycosides, and antioxidants in Ficus deltoidea , a malaysian herbal tea.
PubMed:
Habitual intake of flavonoid subclasses and incident hypertension in adults.
PubMed:
Differential expression of flavonoid biosynthesis genes and accumulation of phenolic compounds in common buckwheat (Fagopyrum esculentum).
PubMed:
Dietary flavonol and flavone intakes and their major food sources in Chinese adults.
PubMed:
Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells.
PubMed:
Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats.
PubMed:
Potent modification of inducible CYP1A1 expression by flavonoids.
PubMed:
Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms.
PubMed:
Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.
PubMed:
Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice.
PubMed:
Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population.
PubMed:
Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation.
PubMed:
Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose.
PubMed:
Mixture effects of dietary flavonoids on steroid hormone synthesis in the human adrenocortical H295R cell line.
PubMed:
Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).
PubMed:
The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.
PubMed:
Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn).
PubMed:
Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice.
PubMed:
Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen.
PubMed:
Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.
PubMed:
Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L.
PubMed:
Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells.
PubMed:
Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm.
PubMed:
Analysis of the residues of 20 organochlorine pesticides in Herba epimedii, a Chinese herbal medicine, by solid-phase extraction with gas chromatography/negative chemical ionization-mass spectrometry.
PubMed:
Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A.
PubMed:
Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth.
PubMed:
Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application.
PubMed:
Dietary flavonoids activate the constitutive androstane receptor (CAR).
PubMed:
Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study.
PubMed:
Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States.
PubMed:
Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice.
PubMed:
Plant chemical defence: a partner control mechanism stabilising plant--seed-eating pollinator mutualisms.
PubMed:
Inhibitory effect of flavonoids on 26S proteasome activity.
PubMed:
Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro.
PubMed:
Antioxidant activity of the dihydrochalcones Aspalathin and Nothofagin and their corresponding flavones in relation to other Rooibos ( Aspalathus linearis ) Flavonoids, Epigallocatechin Gallate, and Trolox.
PubMed:
From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine.
PubMed:
Quantitation of chafurosides A and B in tea leaves and isolation of prechafurosides A and B from oolong tea leaves.
PubMed:
Evaluation of the antioxidant activity of non-transformed and transformed pineapple: a comparative study.
PubMed:
Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.
PubMed:
Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits.
PubMed:
New acylated flavone and cyanogenic glycosides from Linum grandiflorum.
PubMed:
Tyrosinase inhibitory polyphenols from roots of Morus lhou.
PubMed:
[Study of alcohol-soluble lignin in cognac spirits].
PubMed:
Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
PubMed:
Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.
PubMed:
Higher dietary flavone, flavonol, and catechin intakes are associated with less of an increase in BMI over time in women: a longitudinal analysis from the Netherlands Cohort Study.
PubMed:
Induction of cytochromes P450 in small intestine by chemopreventive compounds.
PubMed:
On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection.
PubMed:
Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation.
PubMed:
Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays.
PubMed:
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
PubMed:
Stress-induced biosynthesis of dicaffeoylquinic acids in globe artichoke.
PubMed:
Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats.
PubMed:
Dietary flavonoid sources in Australian adults.
PubMed:
Development of a potential reference material for evaluating antioxidant activity.
PubMed:
Fate and impact on microorganisms of rice allelochemicals in paddy soil.
PubMed:
Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds.
PubMed:
Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus.
PubMed:
The influence of diet composition on phase I and II biotransformation enzyme induction.
PubMed:
Online identification of chlorogenic acids, sesquiterpene lactones, and flavonoids in the Brazilian arnica Lychnophora ericoides Mart. (Asteraceae) leaves by HPLC-DAD-MS and HPLC-DAD-MS/MS and a validated HPLC-DAD method for their simultaneous analysis.
PubMed:
Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells.
PubMed:
Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action.
PubMed:
Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities.
PubMed:
Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages.
PubMed:
Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells.
PubMed:
[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed:
Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones.
PubMed:
How heating affects extra virgin olive oil quality indexes and chemical composition.
PubMed:
Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography.
PubMed:
Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal.
PubMed:
A new flavone glycoside from the fruits of Luffa cylindrica.
PubMed:
Activity and allelopathy of soil of flavone o-glycosides from rice.
PubMed:
Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids.
PubMed:
Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits.
PubMed:
Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids.
PubMed:
Dietary intakes of flavonols and flavones and coronary heart disease in US women.
PubMed:
The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes.
PubMed:
Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats.
PubMed:
Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo.
PubMed:
Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit.
PubMed:
Novel transgenic rice overexpressing anthocyanidin synthase accumulates a mixture of flavonoids leading to an increased antioxidant potential.
PubMed:
TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.
PubMed:
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
PubMed:
An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers.
PubMed:
Total antioxidant activity and fiber content of select Florida-grown tropical fruits.
PubMed:
[Chemical constituents of C-glycosylflavones from Mimosa pudica].
PubMed:
Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.
PubMed:
Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
PubMed:
Fourier transform infrared spectroscopic analysis of the polymethoxylated flavone content of orange oil residues.
PubMed:
Thermal degradation kinetics of isoflavone aglycones from soy and red clover.
PubMed:
Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis.
PubMed:
Bioavailability of apigenin from apiin-rich parsley in humans.
PubMed:
Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction.
PubMed:
Flavone C-glycosides from leaves of Oxalis triangularis.
PubMed:
Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells.
PubMed:
Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.
PubMed:
Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS.
PubMed:
Extraction and identification of natural antioxidant from Sideritis euboea (mountain tea).
PubMed:
Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives.
PubMed:
Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids.
PubMed:
Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells.
PubMed:
Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells.
PubMed:
Human gut microbial degradation of flavonoids: structure-function relationships.
PubMed:
Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products.
PubMed:
Determination of flavone C-glucosides in antioxidant of bamboo leaves (AOB) fortified foods by reversed-phase high-performance liquid chromatography with ultraviolet diode array detection.
PubMed:
Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species.
PubMed:
Fractionation of orange peel phenols in ultrafiltered molasses and mass balance studies of their antioxidant levels.
PubMed:
Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells.
PubMed:
Three new furostanol saponins from the leaves of Lycianthes synanthera ("Chomte"), an edible Mesoamerican plant.
PubMed:
Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry.
PubMed:
Secondary metabolites from the leaves of Feijoa sellowiana Berg.
PubMed:
Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet.
PubMed:
Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship.
PubMed:
Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells.
PubMed:
Natural products for dental caries prevention.
PubMed:
Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavone.
PubMed:
Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.
PubMed:
Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling.
PubMed:
Antioxidant properties of phenolic compounds from Pelargonium reniforme.
PubMed:
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.
PubMed:
Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.
PubMed:
Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation.
PubMed:
Effect of flavonoids on feeding preference and development of the crucifer pest Mamestra configurata Walker.
PubMed:
Purification and characterization of an isoflavone-conjugates-hydrolyzing beta-glucosidase from endophytic bacterium.
PubMed:
Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
PubMed:
Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution.
PubMed:
Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification.
PubMed:
Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
PubMed:
Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis.
PubMed:
Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.
PubMed:
Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents.
PubMed:
Phenolic constituents and antioxidant properties of Xanthosoma violaceum leaves.
PubMed:
Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
PubMed:
Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
PubMed:
Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc.
PubMed:
Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations.
PubMed:
Flavonoid intake and the risk of cardiovascular disease in women.
PubMed:
Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.
PubMed:
Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments.
PubMed:
Insect antifeedant activity of flavones and chromones against Spodoptera litura.
PubMed:
Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats.
PubMed:
Flavonol and flavone intakes in US health professionals.
PubMed:
Antiproliferative activities of citrus flavonoids against six human cancer cell lines.
PubMed:
Flavonoid oxidation by the radical generator AIBN: a unified mechanism for quercetin radical scavenging.
PubMed:
Alfalfa (Medicago sativa L.) flavonoids. 2. Tricin and chrysoeriol glycosides from aerial parts.
PubMed:
Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation.
PubMed:
Dietary agents in cancer prevention: flavonoids and isoflavonoids.
PubMed:
Immunotoxicity of a standardized citrus polymethoxylated flavone extract.
PubMed:
Quantitative study of fruit flavonoids in citrus hybrids of King (C. nobilis) and Mukaku Kishu (C. kinokuni).
PubMed:
Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents.
PubMed:
Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN Study.
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Effects of simple aromatic compounds and flavonoids on Ca2+ fluxes in rat pituitary GH(4)C(1) cells.
PubMed:
Inhibition of beta-carotene-15,15'-dioxygenase activity by dietary flavonoids.
PubMed:
Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus.
PubMed:
A new flavone O-glycoside and other constituents from wheat leaves (Triticum aestivum L.).
PubMed:
Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.
PubMed:
Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages.
PubMed:
Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds.
PubMed:
Identification of flavone C-glycosides including a new flavonoid chromophore from barley leaves (Hordeum vulgare L.) by improved NMR techniques.
PubMed:
High content of dopamine, a strong antioxidant, in Cavendish banana.
PubMed:
Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects.
PubMed:
Structure-activity relationship of polyphenols on inhibition of chemical mediator release from rat peritoneal exudate cells.
PubMed:
Differential effect of flavonoids on inhibition of secretion and accumulation of secretory granules in rat basophilic leukemia cells.
PubMed:
Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices.
PubMed:
Transepithelial transport and accumulation of flavone in human intestinal Caco-2 cells.
PubMed:
Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
PubMed:
Isolation of a novel NAD(P)H-quinone oxidoreductase from the cyanobacterium Synechocystis PCC6803.
PubMed:
[Flavonols, flavone and anthocyanins as natural antioxidants of food and their possible role in the prevention of chronic diseases].
PubMed:
Flavonoid deactivation of ferrylmyoglobin in relation to ease of oxidation as determined by cyclic voltammetry.
PubMed:
The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study.
PubMed:
Effects of co-administration of butylated hydroxytoluene, butylated hydroxyanisole and flavonoids on the activation of mutagens and drug-metabolizing enzymes in mice.
PubMed:
The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.
PubMed:
Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
PubMed:
Orange juice classification with a biologically based neural network.
PubMed:
Interaction of 5,7-dihydroxy-4'-methoxyflavone with a multisubunit protein, carmin: thermodynamics and kinetics of interaction.
PubMed:
Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine.
PubMed:
Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes.
PubMed:
Antimutagenic effect of plant flavonoids in the Salmonella assay system.
PubMed:
Flavonoid inhibition of aromatase enzyme activity in human preadipocytes.
PubMed:
Determination of flavone C-glycosides in tea.
PubMed:
Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food.
PubMed:
Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344 Rats (Feed Studies).
PubMed:
Laboratory colonization has not reduced constitutive or induced polysubstrate monooxygenase activity in velvetbean caterpillars.
PubMed:
Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids.
PubMed:
Biotransformation of the Pentahydroxy Flavone Quercetin by Rhizobium loti and Bradyrhizobium Strains (Lotus).
PubMed:
Inhibition of ethoxyresorufin deethylase activity by natural flavonoids in human and rat liver microsomes.
PubMed:
Benzanthrone: a new substrate for hepatic microsomal cytochrome P-450.
PubMed:
Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids.
PubMed:
Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species.
PubMed:
Comparison of the effects of feeding quercetin or flavone on hepatic and intestinal drug-metabolizing enzymes of the rat.
PubMed:
Flavones in citrus exhibit antiadhesive action on platelets.
PubMed:
Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes.
PubMed:
A factor in food which impairs Na+-K+-ATPase in vitro.