2-acetyl pyrazine

1-pyrazin-2-ylethanone

CAS: 22047-25-2 C6 H6 N2 O MW: 122.12702000 popcorn roasted

Identification

Name2-acetyl pyrazine
IUPAC1-pyrazin-2-ylethanone
CAS Number22047-25-2
EINECS244-753-5
FDA UNIIGR391IBU5C
Molecular FormulaC6 H6 N2 O
Molecular Weight122.12702000
MDL NumberMFCD00006134
Nikkaji NumberJ27.905F
CoE Number2286
XlogP30.20 (est)

Regulatory

JECFA Food Flavoring784 2-acetylpyrazine
DG SANTE Food Flavourings14.032 2-acetylpyrazine
FEMA Number3126
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)22047-25-2 ; ACETYLPYRAZINE

Physical Properties

Appearance white to pale yellow crystalline powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed Yes
Melting Point 76.00 to 78.00 °C. @ 760.00 mm Hg
Boiling Point 188.00 to 190.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.188000 mmHg @ 25.00 °C.
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 0.200
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength very high ,
Substantivity 400 hour(s) at 10.00 % in dipropylene glycol
Odor Description
at 0.10 % in propylene glycol.
Musty, roasted, corn chip, popcorn, nutty and potato-like
popcorn; nutty, bread crust
chocolate, coffee, nut, popcorn
Sweet, Nutty, Caramellic/ Caramel, Popcorn
Popcorn, chocolate, nut and toast
Odor sample from Sigma-Aldrich
Taste Description
at 10.00 ppm.
nutty
chocolate, popcorn in dilution (10ppm)

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M,F] > 3000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for 2-acetyl pyrazine usage levels up to0.0500 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)12.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)120.00 (μg/capita/day)
Structure ClassII
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Advanced Biotech. Inc.

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Alfrebro LLC/ Archer Daniels Midland Company

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Fleurchem, Inc.

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FRUTAROM USA INC,

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M&U International LLC

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Robinson Brothers Limited

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Sigma-Aldrich

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Potential Uses

FR acorn FL almond toasted almond FL barley FR bread baked bread FL bread crust FL bread rye bread FL bread wheat bread FL bread white bread FL cake FL cashew FL chocolate cocoa FR coffee FL corn chip FR filbert FR gingerbread FR graham cracker FR hazelnut FL nut roasted nut FR peanut FL pecan FL pistachio FR pizza FR popcorn FL sesame FL taco toasted wheat

Natural Occurrence

almond roasted almond bread PMC cocoa coffee PMC filbert peanut popcorn PMC potato chip PMC sesame oil

Synonyms

acetyl pyrazine 2- acetyl pyrazine 2- acetyl pyrazine FCC acetyl-2 pyrazine 2- acetylpyrazine acetylpyrazine 2- acetylpyrazine FCC ethanone, 1-(2-pyrazinyl)- ethanone, 1-pyrazinyl- ketone, methyl pyrazinyl methyl 2-pyrazinyl ketone methyl pyrazin-2-yl ketone methyl pyrazinyl ketone methyl-2-pyrazinyl ketone methylpyrazinyl ketone popcorn pyrazine pyrazin-1-ylethan-1-one 1- pyrazin-2-yl-ethanone 1-( pyrazin-2-yl)ethan-1-one 1-( pyrazin-2-yl)ethanone 1- pyrazin-2-ylethan-1-one 1- pyrazin-2-ylethanone pyrazine, 2- acetyl pyrazine, 2-acetyl- 1- pyrazinylethanone Perfumer & Flavorist: Flavor Bites: 2-Acetyl Pyrazine US Patents: 3,952,024 - Furfurylthioacetone PubMed: Identification of potent odorants formed during the preparation of extruded potato snacks. US Patents: 3,931,166 - Certain 2,5-dimethyl-3-thiopyrazines PubMed: Gas chromatography-olfactometry and chemical quantitative study of the aroma of six premium quality spanish aged red wines. PubMed: How low pH can intensify beta-damascenone and dimethyl trisulfide production through beer aging. PubMed: Main group bismuth(III), gallium(III) and diorganotin(IV) complexes derived from bis(2-acetylpyrazine)thiocarbonohydrazone: synthesis, crystal structures and biological evaluation. PubMed: Synthesis, crystal structures, in vitro biological evaluation of zinc(II) and bismuth(III) complexes of 2-acetylpyrazine N(4)-phenylthiosemicarbazone. PubMed: Cytotoxicity and structure-activity relationships of four alpha-N-heterocyclic thiosemicarbazone derivatives crystal structure of 2-acetylpyrazine thiosemicarbazone. PubMed: (E)-2-Acetyl-pyrazine 4-nitro-phenyl-hydrazone. PubMed: Effect of cysteine and cystine addition on sensory profile and potent odorants of extruded potato snacks. PubMed: 2-Acetyl-pyrazine 4-methyl-thio-semi-carbazone. PubMed: New Ag(I)-containing coordination polymers generated from multidentate Schiff-base ligands. PubMed: Solvent-free reactions of C60 with active methylene compounds, either with or without carbon tetrabromide, in the presence of bases under high-speed vibration milling conditions. PubMed: 2-benzoxazolyl and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine: a novel class of antitumor agents. PubMed: Studies on pyrazine derivatives--XXXIV. Synthesis and tuberculostatic activity of alpha-oxo ketene dithioacetals pyrazine derivatives. PubMed: Measurement of interactions between polysaccharides and flavour compounds by exclusion size chromatography: advantages and limits.