glutathione

5-L-glutamyl-L-cysteinylglycine

CAS: 70-18-8 C10 H17 N3 O6 S MW: 307.32669000

Identification

Nameglutathione
IUPAC(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
CAS Number70-18-8
EINECS200-725-4
FDA UNIIGAN16C9B8O
Molecular FormulaC10 H17 N3 O6 S
Molecular Weight307.32669000
MDL NumberMFCD00065939
Nikkaji NumberJ10.686K
Beilstein1729812

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 293

Physical Properties

Appearance white powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 195.00 °C. @ 760.00 mm Hg
Boiling Point 754.00 to 755.00 °C. @ 760.00 mm Hg (est)
Flash Point 770.00 °F. TCC ( 410.10 °C. ) (est)
logP (o/w) -1.645 (est)
Soluble in water, 1.927e+005 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesreducing agents

No sensory data available

Safety Information

Oral/Parenteral Toxicityintravenous-rabbit LD50 > 2000 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient adjuncts, dietary supplements, nutrient agents
Recommendation for glutathione usage levels up tonot for fragrance use.
Recommendation for glutathione flavor usage levels up tonot for flavor use.

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Potential Uses

biological additives

Natural Occurrence

bean black bean root bean fava bean bean mung bean sprout black gram seed corn fruit corn root corn seed garlic bulb lotus indian lotus seed onion bulb peanut seed potato plant purslane herb spinach plant

Synonyms

(S)-2- amino-5-((R)-1-(carboxymethylamino)-3-mercapto-1-oxopropan-2-ylamino)-5-oxopentanoic acid (2S)-2- amino-5-({(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoic acid (2S)-2- amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid deltathione N-(N-L-g- glutamyl-L-cysteinyl)glycine N-(N-L-gamma- glutamyl-L-cysteinyl)glycine 5-L- glutamyl-L-cysteinylglycine L- glutamyl-L-cysteinylglycine glutathiol L- glutathione L- glutathione reduced glutathione reduced form glutathione, reduced form L- glutatione PubMed: Evolved Saccharomyces cerevisiae wine strains with enhanced glutathione production obtained by an evolution-based strategy. PubMed: Secretion expression of SOD1 and its overlapping function with GSH in brewing yeast strain for better flavor and anti-aging ability. PubMed: Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death. PubMed: Direct accurate analysis of cysteinylated and glutathionylated precursors of 4-mercapto-4-methyl-2-pentanone and 3-mercaptohexan-1-ol in must by ultrahigh performance liquid chromatography coupled to mass spectrometry. PubMed: Leaf proteome profiling of transgenic mint infected with Alternaria alternata. PubMed: Restoration of brain antioxidant status by hydroalcoholic extract of Mimusops elengi flowers in rats treated with monosodium glutamate. PubMed: New insights into sulfur metabolism in yeasts as revealed by studies of Yarrowia lipolytica. PubMed: Response surface methodology for meat-like odorants from Maillard reaction with glutathione I: the optimization analysis and the general pathway exploration. PubMed: Integrated expression of the α-amylase, dextranase and glutathione gene in an industrial brewer's yeast strain. PubMed: Construction of self-cloning, indigenous wine strains of Saccharomyces cerevisiae with enhanced glycerol and glutathione production. PubMed: Sensory characteristics and consumer acceptability of beef stock containing the glutathione-xylose Maillard reaction product and/or monosodium glutamate. PubMed: 4-(2-Hydroxypropan-2-yl)-1-methylcyclohexane-1,2-diol prevents xenobiotic induced cytotoxicity. PubMed: Response surface methodology for meat-like odorants from the Maillard reaction with glutathione II: the tendencies analysis of meat-like donors. PubMed: Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice. PubMed: Toxic effects of some synthetic food colorants and/or flavor additives on male rats. PubMed: Development of Saccharomyces cerevisiae producing higher levels of sulfur dioxide and glutathione to improve beer flavor stability. PubMed: Metabolomic approach for determination of key volatile compounds related to beef flavor in glutathione-Maillard reaction products. PubMed: Sensory characteristics and consumer acceptability of beef stock containing glutathione Maillard reaction products prepared at various conditions. PubMed: Impacts of glutathione Maillard reaction products on sensory characteristics and consumer acceptability of beef soup. PubMed: Identification of impact odorants contributing to fresh mushroom off-flavor in wines: incidence of their reactivity with nitrogen compounds on the decrease of the olfactory defect. PubMed: Construction of amylolytic industrial brewing yeast strain with high glutathione content for manufacturing beer with improved anti-staling capability and flavor. PubMed: Environmental stress enhances biosynthesis of flavor precursors, S-3-(hexan-1-ol)-glutathione and S-3-(hexan-1-ol)-L-cysteine, in grapevine through glutathione S-transferase activation. PubMed: The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. PubMed: Sensory characteristics and consumer acceptability of beef soup with added glutathione and/or MSG. PubMed: Glutamate. Its applications in food and contribution to health. PubMed: A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. PubMed: Free amino acid production during tomato fruit ripening: a focus on L-glutamate. PubMed: [Effects of knockout ECM25/YJL201W gene in brewing yeast on beer flavor stability]. PubMed: Over-expression of GSH1 gene and disruption of PEP4 gene in self-cloning industrial brewer's yeast. PubMed: Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes. PubMed: Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin. PubMed: The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. PubMed: A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions. PubMed: Chemometric modeling to relate antioxidants, neutral lipid fatty acids, and flavor components in chicken breasts. PubMed: Isothiocyanates in cancer prevention. PubMed: NTP toxicology and carcinogensis Studies of 2,4-hexadienal (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) (Gavage Studies). PubMed: II. Glutamine and glutamate. PubMed: Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. PubMed: Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. PubMed: Decrease of hepatic catalase level by treatment with diallyl sulfide and garlic homogenates in rats and mice. PubMed: Flavor characteristics of glutathione in raw and cooked foodstuffs. PubMed: Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats. PubMed: Pathways of metabolism of [1'-14C]-trans-anethole in the rat and mouse. PubMed: Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice. PubMed: Differential induction of glutathione transferase isoenzymes of mice stomach by diallyl sulfide, a naturally occurring anticarcinogen.