hematin
hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron
Identification
| Name | hematin |
| IUPAC | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate |
| CAS Number | 15489-90-4 |
| EINECS | 239-518-9 |
| FDA UNII | 0WP180G15G |
| Molecular Formula | C34 H34 Fe N4 O5 |
| Molecular Weight | 634.51398000 |
| MDL Number | MFCD00011615 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 1128.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 1177.00 °F. TCC ( 636.30 °C. ) (est) |
| logP (o/w) | 7.193 (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-rat LD50 43 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"\nVASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION\nBLOOD: HEMORRHAGE']
Safety in Use
| Category | cosmetic ingredient for hair conditioning |
| Recommendation for hematin usage levels up to | not for fragrance use. |
| Recommendation for hematin flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
dihydrogen hydroxy(3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-n21,n22,n23,n24)ferrate(2-)
hematin from bovine blood
3-[18-(2-
carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate
ferrihemate
ferriheme
haematin
hydroxo(protoporphyrinato)iron(III)
hydroxo[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(III)
hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron
hydroxyhemin
iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-hydroxy-
phenodin
protohematin
PubMed:
Blood meal-based compound. Good choice as iron fertilizer for organic farming.
PubMed:
Hemozoin accumulation in Garnham bodies of Plasmodium falciparum gametocytes.
PubMed:
Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to β-hematin in acidic environment at malarial fever temperature.
PubMed:
Dietary iron-initiated lipid oxidation and its inhibition by polyphenols in gastric conditions.
PubMed:
Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study.
PubMed:
Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution.
PubMed:
Factors in various fractions of meat homogenates that affect the oxidative stability of raw chicken breast and beef loin.
PubMed:
Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review.
PubMed:
Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A.
PubMed:
The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2).
PubMed:
Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution.
PubMed:
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
PubMed:
Structural analysis of the anti-malaria active agent chloroquine under physiological conditions.
PubMed:
Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update.
PubMed:
Resonance Raman spectroscopy in malaria research.
PubMed:
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.
PubMed:
Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
PubMed:
A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds.
PubMed:
1,4-bis(3-aminopropyl)piperazine libraries: from the discovery of classical chloroquine-like antimalarials to the identification of new targets.
PubMed:
Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro.
PubMed:
Raman imaging of hemozoin within the food vacuole of Plasmodium falciparum trophozoites.
PubMed:
Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position.
PubMed:
Concentration effects in myoglobin-catalyzed peroxidation of linoleate.
PubMed:
On the mechanism of hemozoin production in malaria parasites: activated erythrocyte membranes promote beta-hematin synthesis.
PubMed:
Generation of lipid peroxyl radicals from edible oils and their biological activities: a need for consideration for anti-radical components and purification processing.
PubMed:
Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry.
PubMed:
Phagocytosis of hemozoin (native and synthetic malaria pigment), and Plasmodium falciparum intraerythrocyte-stage parasites by human and mouse phagocytes.
PubMed:
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.
PubMed:
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.
PubMed:
Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine.
PubMed:
Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei.
PubMed:
The ultrastructure of the gastrodermis and the nutrition of the gill parasitic Atriaster heterodus Lebedev and Paruchin, 1969 (Platyhelminthes: Monogenea).
PubMed:
Access to hematin: the basis of chloroquine resistance.
PubMed:
The iron environment in heme and heme-antimalarial complexes of pharmacological interest.
PubMed:
High-performance liquid chromatographic analysis of biological and chemical heme polymerization.
PubMed:
Influence of pH, salt and nitrite on the heme-dependent catalase activity of lactic acid bacteria.
PubMed:
Heme-dependent catalase activity of lactobacilli.
PubMed:
Biochemical characterization of Plasmodium falciparum hemozoin.
PubMed:
Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin.
PubMed:
Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method.
PubMed:
Protein changes in frozen fish.
PubMed:
Phagotrophy and two new structures in the malaria parasite Plasmodium berghei.