hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron

CAS: 15489-90-4 C34 H34 Fe N4 O5 MW: 634.51398000

Identification

Namehematin
IUPAC3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate
CAS Number15489-90-4
EINECS239-518-9
FDA UNII0WP180G15G
Molecular FormulaC34 H34 Fe N4 O5
Molecular Weight634.51398000
MDL NumberMFCD00011615

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 1128.50 °C. @ 760.00 mm Hg (est)
Flash Point 1177.00 °F. TCC ( 636.30 °C. ) (est)
logP (o/w) 7.193 (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshair conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-rat LD50 43 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"\nVASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION\nBLOOD: HEMORRHAGE']

Safety in Use

Categorycosmetic ingredient for hair conditioning
Recommendation for hematin usage levels up tonot for fragrance use.
Recommendation for hematin flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

biological additives

Natural Occurrence

cacao bean horseradish root

Synonyms

dihydrogen hydroxy(3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-n21,n22,n23,n24)ferrate(2-) hematin from bovine blood 3-[18-(2- carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate ferrihemate ferriheme haematin hydroxo(protoporphyrinato)iron(III) hydroxo[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(III) hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron hydroxyhemin iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-hydroxy- phenodin protohematin PubMed: Blood meal-based compound. Good choice as iron fertilizer for organic farming. PubMed: Hemozoin accumulation in Garnham bodies of Plasmodium falciparum gametocytes. PubMed: Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to β-hematin in acidic environment at malarial fever temperature. PubMed: Dietary iron-initiated lipid oxidation and its inhibition by polyphenols in gastric conditions. PubMed: Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study. PubMed: Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution. PubMed: Factors in various fractions of meat homogenates that affect the oxidative stability of raw chicken breast and beef loin. PubMed: Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. PubMed: Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A. PubMed: The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2). PubMed: Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution. PubMed: Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. PubMed: Structural analysis of the anti-malaria active agent chloroquine under physiological conditions. PubMed: Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update. PubMed: Resonance Raman spectroscopy in malaria research. PubMed: Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity. PubMed: Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. PubMed: A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds. PubMed: 1,4-bis(3-aminopropyl)piperazine libraries: from the discovery of classical chloroquine-like antimalarials to the identification of new targets. PubMed: Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro. PubMed: Raman imaging of hemozoin within the food vacuole of Plasmodium falciparum trophozoites. PubMed: Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position. PubMed: Concentration effects in myoglobin-catalyzed peroxidation of linoleate. PubMed: On the mechanism of hemozoin production in malaria parasites: activated erythrocyte membranes promote beta-hematin synthesis. PubMed: Generation of lipid peroxyl radicals from edible oils and their biological activities: a need for consideration for anti-radical components and purification processing. PubMed: Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry. PubMed: Phagocytosis of hemozoin (native and synthetic malaria pigment), and Plasmodium falciparum intraerythrocyte-stage parasites by human and mouse phagocytes. PubMed: Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. PubMed: Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. PubMed: Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine. PubMed: Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. PubMed: The ultrastructure of the gastrodermis and the nutrition of the gill parasitic Atriaster heterodus Lebedev and Paruchin, 1969 (Platyhelminthes: Monogenea). PubMed: Access to hematin: the basis of chloroquine resistance. PubMed: The iron environment in heme and heme-antimalarial complexes of pharmacological interest. PubMed: High-performance liquid chromatographic analysis of biological and chemical heme polymerization. PubMed: Influence of pH, salt and nitrite on the heme-dependent catalase activity of lactic acid bacteria. PubMed: Heme-dependent catalase activity of lactobacilli. PubMed: Biochemical characterization of Plasmodium falciparum hemozoin. PubMed: Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin. PubMed: Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method. PubMed: Protein changes in frozen fish. PubMed: Phagotrophy and two new structures in the malaria parasite Plasmodium berghei.